Effect of Surfaces on Protein Folding and Assembly

Seminar series
Physical Chemistry Seminar
Mon, Jun 3 4:00pm
2033 Young Hall
Speaker Professor Joan-Emma Shea
University of California, Santa Barbara
Dept. of Chemistry and Biochemistry

Abstract: The folding of a protein to its native state is critical for the correct functioning of the cell. When proteins do not fold correctly, they can self-assembly into large aggregate structures that can deposit on organs in the body. A number of diseases, including Type II Diabetes and Alzheimer’s Disease, are associated with this pathological process. Under cellular conditions, proteins encounter a variety of surfaces, from chaperones to membranes, that can dramatically alter folding pathways. In this talk, I will present atomistic and coarse-grained simulations that probe the effect of surfaces on protein folding and aggregation mechanisms.