Copper Catalysis for Direct Formation of Heteroaromatics and Tetrasubstituted Carbons Bearing Amines

Seminar series
Organic Colloquium
When
Thu, Apr 18 5:00pm
Where
Cram Conference Room – 3440 Mol Sci
Speaker Professor Catharine H. Larsen
University of California, Riverside
Department of Chemistry
Description

Copper Catalysis for Direct Formation of Heteroaromatics and Tetrasubstituted Carbons Bearing Amines

Abstract.  Copper catalysts are capable of creating structurally diverse products by coupling an amine, alkyne, and carbonyl compound.  Second-generation green processes operate with zero waste (as the sole by-product is 1 equivalent of water) and allow for the incorporation of alkyl groups on heteroarenes, critical for ongoing testing of potential anticancer therapies. The mechanistic requirements to overcome each barrier to new reaction development are discussed.  The first catalytic ketone-amine-alkyne coupling of acyclic ketones provides direct formation of fully-substituted carbons bearing amines and may open the door to additions of other nucleophiles in these types of multicomponent reactions.

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