Construction and Deconstruction of Three-Dimensional Molecules: Prof. Thomas Magauer

Seminar series
Organic Colloquium
Mon, Sep 16 2:00pm to 3:00pm
Molecular Sciences 3440
Speaker Thomas Magauer
University of Innsbruck
Chemistry and Biomedicine

Construction and Deconstruction of Three-Dimensional Molecules

Abstract: Natural products constitute a vast and largely unexplored library of complex molecular architectures, and are a fundamental source for novel bioactive agents. However, the complex architecture of these molecules often prevents their application in medicinal chemistry. For us, this is an inspiration to think about innovative retrosynthetic bond disconnections which enable rapid access to the target compounds. We want to discover, design and develop powerful transformations such as cationic cyclizations and ring-expansions and apply them to the synthesis of biologically relevant complex natural products and simplified analogs thereof. The goal of these projects is to shed light on proposed biosynthetic processes, to identify new molecular targets and ultimately provide new lead compounds for the treatment of human diseases.