*CANCELED* “Re-Engineering the Natural Product, Emetine, For the Purpose of Achieving a Therapeutically Useful Drug”

Seminar series
Organic Colloquium
When
Thu, Jun 8 5:00pm
Where
CS24 Young Hall
Speaker Professor Oladapo Bakare
Howard University
Department of Chemistry
Description

*** CANCELED SEMINAR ***

Organic Colloquium

Re-Engineering the Natural Product, Emetine, For the Purpose of Achieving a Therapeutically Useful Drug

Abstract.  Emetine is a natural product alkaloid with protein synthesis inhibitory activity. It is known to have a number of medicinal properties including anti-parasitic and anticancer activities. However, extreme toxicity including cardiotoxicity rendered it clinically undesirable as a therapeutic drug. In our efforts to develop clinically useful anticancer agents based on natural products scaffold, we find emetine to be an attractive scaffold for chemical transformation.  Consequently, our research group has been involved in the development of emetine derivatives with the goal to obtain a therapeutically useful anticancer agent that eliminates or significantly reduce the undesirable toxic side effects associated with emetine. This talk will focus on design, synthesis and biological evaluation of natural product derivatives, with particular emphasis on the development of emetine analogs and prodrugs with potential in prostate cancer treatment.

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