C-H and C-O Functionalization via Radical Chaperones

Seminar series
Organic Colloquium
Thu, Feb 27 4:00pm
CS 76
Speaker Professor David Nagib
The Ohio State University
Department of Chemistry & Biochemistry

Abstract: Our research is focused on harnessing the untapped reactivity of abundant chemical feedstocks to enable late-stage functionalization of medicinally relevant molecules. We have recently developed new approaches for selective C-H and C-O functionalization of alcohols, amines, and carbonyls, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. These radical chaperone strategies have enabled discovery of new classes of reactivity to streamline the synthesis of complex molecules with biological and industrial significance.