SPRING 2021 DISTINGUISHED LECTURE - 30 years of Molecular Glues: Controlling Cell Circuitry in Biology and Medicine - Stuart L. Schreiber, Harvard University

Tue, Apr 6 4:00pm
Online via Zoom
Speaker Stuart L. Schreiber
Hosted by
UCLA Department of Chemistry & Biochemistry

We are delighted to invite you to join us for the UCLA Department of Chemistry & Biochemistry Distinguished Lecture Series, which is be a department-wide colloquium in a special week with no other seminars! The lecture will target students, faculty, friends, and alumni. 

Dr. Stuart L. Schreiber
Morris Loeb Professor, Harvard University
Co-Founder, Broad Institute

"30 years of Molecular Glues:
Controlling Cell Circuitry in Biology and Medicine"

Abstract: This coming year marks the 50th and 35th anniversaries of the reporting of the natural products and immunosuppressants cyclosporin A (CsA; sandimmune) and FK506 (tacrolimus), respectively, and the 30th anniversary of the revelation, published in Cell in 1991, that both compounds act in a way previously not seen – as “molecular glues” that induce protein–protein associations. On this occasion, and as the realization that additional transformative medicines also act as molecular glues continues to fuel the surge of interest in diverse chemical strategies for inducing functional protein–protein associations, I will explore the arc of this story and present new advances in the discovery of small-molecule binders and molecular glues.
Register for the event by April 2nd at https://forms.gle/zdZcgSsVTL6ajvt86.
To learn more about the Distinguished Lecture Series visit the series website.