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Jeffrey I. Zink Inorganic Chemistry Seminar Series – Prof. Gonçalo Bernardes

Divisional Seminars, Inorganic

When
October 15, 2024 4:00 pm - 5:00 pm
Where

Description

Flyer: Prof. Gonçalo Bernardes Flyer

Title: “Translational Chemical Biology”

Abstract: Our research uses chemistry principles to address questions of importance in life sciences and molecular medicine. This lecture will cover recent examples of emerging areas in our group in: i. methods for site-selective chemical modification of proteins and antibodies; ii. bioorthogonal cleavage reactions for targeted drug activation in cells; iii. click-degraders, small molecules that when in proximity can degrade RNA, akin to ribonucleases. Using click-degraders we developed 1) meCLICK-Seq, a powerful method for the study of diverse aspects of cellular RNA methylation, and 2) proximity-driven small molecule RNA degraders to target and degrade SARS-CoV-2 genomes and exert an antiviral effect in disease models.