The 2018 M. Frederick Hawthorne Lecture

Wed, Jan 31 4:00pm
CNSI Auditorium
Speaker Stephen L. Buchwald
Hosted by
Made Possible by The Raymond and Dorothy Wilson Endowment
Alexander Spokoyny

Palladium-Based Methodology in Imaging and Bioconjugation

We have started to apply methodology related to Pd-catalyzed C-N coupling to the preparation of isotopically labelled compounds for the purposes of imaging (cf. J. Am. Chem. Soc. 2017, 139, 7152). Additionally, we are working in a variety of areas dealing with the functionalization of biomolecules including peptides, proteins and antibodies (Nature, 2015, 526, 687, Org. Lett. 2017, 19, 4263).

This lecture will describe: 1) Our work on the preparation of 11C-labelled small molecules and peptides. 2) The development of technology for the functionalization of peptides and proteins. 3) A new method for the synthesis of stapled peptides. 4) Applications to the preparation of antibody drug conjugates.