2017 Bristol-Myers Squibb – UCLA Lectureship

Thu, May 18 1:30pm
Cram Conference Room – 3440 Molecular Sciences Bldg
Speaker Dr. John Hynes
Hosted by
UCLA Department of Chemistry and Biochemistry

The 2017 Bristol-Myers Squibb – UCLA Lectureship


1:30 PM Lecture

Cram Conference Room – 3440 Molecular Sciences Bldg

Discovery of Pyridine Amide Based Inhibitors of Interleukin Receptor- Associated Kinase 4 (IRAK4) for the Treatment of Lupus

Dr. John Hynes

Senior Principal Scientist, Immunology Discovery Chemistry

Bristol-Myers Squibb Co.

Abstract.  IRAK4 is a member of the IRAK family of serine-threonine kinases which signals downstream of toll-like receptors (TLRs) and IL-1 receptors.  TLRs are centrally critical to innate immune system defense due to their ability to recognize molecular patterns associated with various pathogens.  These receptors also detect damage-associated molecular pathogens (DAMPs) generated in the course of chronic autoimmune disease states such as lupus.  The location of IRAK4 downstream of these innate immune system signaling receptors has resulted in significant interest in therapeutic targeting of IRAK4 in autoimmune diseases.


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5:00 PM Lecture

CS24 Young Hall

Some Efforts in Natural Product Synthesis Design

Professor Christopher D. Vanderwal

Department of Chemistry

University of California, Irvine

Abstract.  Complex molecule synthesis benefits from both methodological advances and strategic innovation. With the belief that a quality synthesis requires a solid strategy, our group focuses largely on synthesis design. In this lecture, I will describe some successes and some ongoing attempts to devise and execute concise syntheses of complex secondary metabolites. Often, the targets are potentially valuable for their biological activities, in which case general applicability to a range of family members and/or unnatural analogues is incorporated into the design. Our current interests, from which the lecture will draw from, include polycyclic terpenoids, alkaloids, and polyhalogenated natural products.


Thursday, May 18, 2017