Martinson, Harold G.

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Professor Emeritus
Graduate Program in Biochemistry and Molecular Biology, JCCC Gene Regulation Program Area

Contact Information

Young Hall 5040A
(310) 825-3767
Young Hall 5033
(310) 825-4916

Short Biography

Dr. Martinson received his Ph.D. in Molecular Biology from the University of California, Berkeley. He was a Postdoctoral Scholar at the University of California, San Francisco.

Research Interest

Coupling of RNA Processing With Transcription

Broadly speaking we are interested in how the genes of organisms transmit their information to the cellular biosynthetic machinery. We are especially interested in how this is accomplished in the most complex of organisms—eukaryotes in general, but especially in mammals. RNA polymerase II is the enzyme charged with initiating the transfer of information from the DNA in the nucleus to the cell cytoplasm via RNA. Amazingly, RNA polymerase not only carries out the intricate task of precisely transcribing the DNA, but it also oversees the elaborate network of events involved in processing the RNA that it makes. Our focus is on the functional interactions of the transcriptional machinery with the machineries responsible for cleavage & polyadenylation and for splicing.














RNA Transcription Model




Tsao David C, Park Noh Jin, Nag Anita, Martinson Harold G   Prolonged á-amanitin treatment of cells for studying mutated polymerases causes degradation of DSIF160 and other proteins. RNA (New York, N.Y.), 2012; 18(2): 222-9.
Martinson, H. G.   An active role for splicing in 3?-end formation Wiley Interdisciplinary Reviews: RNA, 2011; 2(4): 459?470.
Nag Anita, Narsinh Kazim, Martinson Harold G   The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase. Nature structural & molecular biology, 2007; 14(7): 662-9.
Tran DP, Kim SJ, Park NJ, Jew TM, Martinson HG   Mechanism of poly(A) signal transduction to RNA polymerase II in vitro. Molecular and Cellular Biology. , 2001; 21(21): 7495-508.
Chao LC, Jamil A, Kim SJ, Huang L, Martinson HG   Assembly of the cleavage and polyadenylation apparatus requires about 10 seconds in vivo and is faster for strong than for weak poly(A) sites. Molecular and Cellular Biology. , 1999; 19(8): 5588-600.
Yeung G, Choi LM, Chao LC, Park NJ, Liu D, Jamil A, Martinson HG   Poly(A)-driven and poly(A)-assisted termination: two different modes of poly(A)-dependent transcription termination. Molecular and Cellular Biology. , 1998; 18(1): 276-89.