Lin, Yung-Ya


WebsiteHome URL
Division
Physical
Title
Faculty
Associate Professor
Specialties
Biophysics
Structural Biology
Physical
Analytical

Contact Information

Email
Office
Young Hall 2077C
(310) 206-2856
Lab
Young Hall 1040
(310) 825-4091

Short Biography

Professor Lin received his B.S. and M.S. degrees in physical chemistry at National Taiwan University, and PhD in physical chemistry in 1998 from University of California at Berkeley. After working as a Postdoctoral Research Associate in the Department of Chemistry, Princeton University, he joined the faculty at UCLA in 2001.

Biography

Prof. Lin completed his B.S. and M.S. in physical chemistry at National Taiwan University under the supervision of Prof. Lian-Pin Hwang, where they developed new mathematical methods for NMR diffusion study and spectral estimation. He pursued his PhD study with Prof. Alex Pines at University of California at Berkeley on spin dynamics in dipole-coupled many-spin systems in solid-state NMR. They generated new formulation and insights into the effects of quantum decoherence, bath fluctuations, and reaction fields on spin dynamics in quantum dissipative systems based on a spin-boson Hamiltonian. He carried out his postdoctoral research with Prof. Warren in the Department of Chemistry, Princeton University, on nonlinear spin dynamics in solution NMR. They developed the theory and applications of intermolecular quantum coherences and discovered the existence of chaotic spin dynamics in routine experiments. Prof. Lin also holds a degree in Theology from China Evangelical Seminary.

Research Interest

The research theme of Prof. Lin's group is "channeling progress in fundamental spin physics and engineering into significant improvements in magnetic resonance spectroscopy and imaging with valuable applications in the chemical, biological and medical sciences, such as molecular imaging, early tumor/lesion detection, cellular imaging, and nano-medicine." His group encompasses a broad and balanced approach aimed at developing a solid theoretical understanding of new spin phenomena, sound methodology for improving sensitivity and contrast, and innovative applications to solve important biomedical challenges. Specifically, he and his group members currently focus on the following projects in theory, methodology, and applications.

(I) Theory: Quantum Theory for Dynamical Instability in Spin Hamiltonians;
(II) Theory: Nonlinear Spin Engineering with Multiple Feedback-Field Pulses;
(III) Methodology: Feedback-Enhanced MR for Contrast and Sensitivity Enhancement

(IV) Application: Early Tumor/Lesion Detection and Characterization
(V) Application: Nanoscience-Based Molecular Imaging and Cellular Imaging;
(VI) Application: Indirect Detection and Spin Amplification by Hyperpolarization, Diffusion, and Chemical Exchange.

Honors & Awards

  • Camille and Henry Dreyfus Teacher-Scholar Award
  • Hanson-Dow Distinguished Teaching Award
  • NSF CAREER Award
  • UCLA Career Development Award
  • Research Corp. Research Innovation Award
  • Camille and Henry Dreyfus New Faculty Award

Publications

Y.-Y. Lin, S. Y. Huang   Method and System for the Amplification of Nuclear Magnetic Resonance Imaging, , ; PCT/US07/61483.
S. Y. Huang, S. S. Yang, Y.-Y. Lin   Sensitivity of Feedback-Enhanced MRI Contrast to Macroscopic and Microscopic Field Variations, Magn. Reson. Med., 2007; in press.
J. D. Walls, S. Y. Huang, Y.-Y. Lin   Spin Amplification in Solution Magnetic Resonance Using Radiation Damping, J. Chem. Phys., 2007; (127): 054507.
S. Y. Huang, A. Chung, Y.-Y. Lin   Visualizing Feedback-Enhanced Contrast in Magnetic Resonance Imaging, Concepts Magn. Reson. A , 2007; (in press): .
J. D. Walls, Y.-Y. Lin   Constants of Motion in NMR Spectroscopy, Solid State Nucl. Magn. Reson., 2006; (29): 153???160.
S. Datta, S. Y. Huang, Y.-Y. Lin   Contrast Enhancement by Feedback Fields in Magnetic Resonance Imaging, J. Phys. Chem. B, 2006; (110): 22071-22078.
S. Y. Huang, J. K. Furuyama, Y.-Y. Lin   Designing Feedback-Based Contrast Enhancement for In Vivo Imaging, Magn. Reson. Mater. Phys. , 2006; (19): 333-346.
J. D. Walls, S. Y. Huang, Y.-Y. Lin , ???,??? J.   Excitation of Magnetization Using a Modulated Radiation Damping Field, Phys. Chem. B, 2006; (110): 19985-19989.
S. Y. Huang, S. M. Wolahan, G. W. Mathern, D. J. Chute, M. Akhtari, S. T. Nguyen, M. N. Huynh, N. Salamon, Y.-Y. Lin   Improving MRI Differentiation of Gray and White Matter in Epileptogenic Lesions Based on Nonlinear Feedback, Magn. Reson. Med., 2006; (56): 776-786.
S. Datta, S. Y. Huang, Y.-Y. Lin   The Transient Dynamics Leading to Spin Turbulence in High-Field Solution Magnetic Resonance: A Numerical Study, J. Chem. Phys., 2006; (124): 154501.
E. W. Scamman, S. Y. Huang, M. G. Castro, Y.-Y. Lin   Tracking Three-Dimensional Magnetization Trajectories by the Radiation Damping Feedback Field for Differential Spin Control, Chem. Phys. Lett., 2006; (427): 426-431.
S. Datta, S. Y. Huang, Y.-Y. Lin   Understanding Spin Turbulence in Solution Magnetic Resonance Through Phase Space Dynamics and Instability, Concepts Magn. Reson. A, 2006; (28): 410-421.
S. Y. Huang, J. D. Walls, Y. Wang, W. S. Warren, Y.-Y. Lin   Signal Irreproducibility in High-Field Solution Magnetic Resonance Experiments Caused by Spin Turbulence, J. Chem. Phys., 2004; (121): 6105-6109 .
S. Y. Huang, C. Anklin, J. D. Walls, Y.-Y. Lin   Sizable Concentration-Dependent Frequency Shifts in Solution NMR Using Sensitive Probes, J. Am. Chem. Soc., 2004; (126): 15936-15937.
J. D. Walls, F. K. H. Phoa, Y.-Y. Lin   Spin Dynamics at Very High Spin Polarization, Phys. Rev. B, 2004; (70): 174410 .