BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210528T153000
DTEND;TZID=America/Los_Angeles:20210528T153000
DTSTAMP:20260615T085804
CREATED:20210325T212404Z
LAST-MODIFIED:20210325T212404Z
UID:13472-1622215800-1622215800@www.chemistry.ucla.edu
SUMMARY:POSTPONED - Chem 268: Paul Sieminski
DESCRIPTION:Zhou Group \n“TBA”
URL:https://www.chemistry.ucla.edu/seminars/postponed-chem-268-paul-sieminski/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210527T160000
DTEND;TZID=America/Los_Angeles:20210527T160000
DTSTAMP:20260615T085804
CREATED:20210520T152834Z
LAST-MODIFIED:20210520T152834Z
UID:13498-1622131200-1622131200@www.chemistry.ucla.edu
SUMMARY:Chemical Synthesis and Study of Noncanonical Membrane Lipids
DESCRIPTION:Lipid membranes are universal features of living systems\, constituting inner and outer barriers of a biological construct and maintaining non-equilibrium states necessary for life. Evolution has produced a fascinating array of lipid structures that dictate the function of biological membranes\, and organisms devote considerable energy to the synthesis and maintenance of such compositions. Our group has been studying some of the most exotic lipids observed to date\, representing a radical departure from the canonical hydrocarbons that dominate almost all prokaryotic and eukaryotic membranes. While minute amounts have been obtainable from natural sources for structural characterization\, pure quantities of such lipids for function-related studies have not. Our work has established strategies for accessing different classes of noncanonical membrane lipids. Success in this vein has resulted in controllable access to single enantiomers of amphiphilic molecules with routes that are flexible enough to allow for the additional production of non-natural analogues.
URL:https://www.chemistry.ucla.edu/seminars/chemical-synthesis-and-study-noncanonical-membrane-lipids/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210527T120000
DTEND;TZID=America/Los_Angeles:20210527T120000
DTSTAMP:20260615T085804
CREATED:20210331T173327Z
LAST-MODIFIED:20210331T173327Z
UID:13485-1622116800-1622116800@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Yuting Miao
DESCRIPTION:Super-Resolution imaging of plasmonic Near-fields: Overcoming Emitter Mislocalizations
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-yuting-miao/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210526T160000
DTEND;TZID=America/Los_Angeles:20210526T160000
DTSTAMP:20260615T085804
CREATED:20210324T211336Z
LAST-MODIFIED:20210324T211336Z
UID:13465-1622044800-1622044800@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Sen Zhang
DESCRIPTION:“Atomically Precise Nanocrystal Surfaces and Interfaces for Electrocatalysis” \nCatalysis at surfaces and interfaces where there exists bi- or multi-component cooperation has been identified as crucial for many processes related to energy and environmental applications. In this talk\, I will highlight such cooperative catalysis can be synthetically controlled at the surface and interface of atomically precise nanocrystals\, and can play critical roles in maximizing the benefit of oxygen-mediated energy conversion reactions: oxygen reduction reaction (ORR) for fuel cells and oxygen evolution reaction (OER) for water electrolyzer. The first example is M-Pt (M=non-precious metals) core-shell nanocrystals within which desirable/undesirable interfaces between non-precious metal M core and precious metal Pt shell were identified by theoretical calculations and were experimentally balanced by nanocrystal synthesis. The optimized core-shell nanocrystals exhibited favorable interfacial interaction through properly coupled electronic and strain effects\, leading to an enhanced electrocatalytic efficiency towards oxygen reduction reaction (ORR). In the second example\, we modulated the interaction of single-site Co\, Fe\, Ni catalytic centers and inorganic coordination environments in the surface of nanocrystals for electrochemical oxygen evolution reaction (OER). The seamless integration of controlled synthesis of nanocrystals\, operando structural/catalytic characterization\, and advanced theoretical calculation for oxygen electrocatalyst development will be discussed\, which will also be extended to other electrocatalytic processes (e.g. CO2 reduction and biomass-derived molecule upgrading).
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-sen-zhang/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210525T160000
DTEND;TZID=America/Los_Angeles:20210525T160000
DTSTAMP:20260615T085804
CREATED:20210519T211852Z
LAST-MODIFIED:20210519T211852Z
UID:13497-1621958400-1621958400@www.chemistry.ucla.edu
SUMMARY:Modulating the conformation and function of disease-relevant RNA with small molecules
DESCRIPTION:Abstract: Small molecules offer a unique opportunity to target structural and regulatory elements in therapeutically relevant RNAs\, but understanding functional selectivity has been a recurrent challenge in small molecule:RNA recognition.  In particular\, RNAs tend to be more dynamic and offer less chemical functionality than proteins\, and biologically active ligands must compete with the highly abundant and highly structured RNA of the ribosome. Indeed\, the first small molecule drug targeting RNA other than the ribosome was just approved by the US FDA in August of 2020. Our recent survey of the literature revealed little more than one hundred reported chemical probes that target non-ribosomal RNA in biological systems. \nAs part of our efforts to improve small molecule targeting strategies and gain fundamental insights into small molecule:RNA recognition\, we have analyzed patterns in both RNA-biased small molecule chemical space and RNA topological space privileged for differentiation. We have applied these principles to functionally modulate conformations of 3’-triple helix of the long noncoding RNA MALAT1 as well as an enterovirus (EV71) IRES structure\, the latter in collaboration with the labs of Blanton Tolbert (Case Western Reserve University) and Gary Brewer and Mei-Ling Li (Rutgers Robert Wood Johnson Medical School). We have recently translated our success in developing an RNA-targeted antiviral for EV71 to targeting regulatory RNA in SARS-CoV-2.
URL:https://www.chemistry.ucla.edu/seminars/modulating-conformation-and-function-disease-relevant-rna-small-molecules/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210524T160000
DTEND;TZID=America/Los_Angeles:20210524T160000
DTSTAMP:20260615T085804
CREATED:20210323T210018Z
LAST-MODIFIED:20210323T210018Z
UID:13457-1621872000-1621872000@www.chemistry.ucla.edu
SUMMARY:Chem 228: Prof. Zdenka Kuncic
DESCRIPTION:“Harnessing nano-scale functionality for next-generation biomedical and bio-inspired technologies”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-prof-zdenka-kuncic/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210521T153000
DTEND;TZID=America/Los_Angeles:20210521T153000
DTSTAMP:20260615T085804
CREATED:20210325T212134Z
LAST-MODIFIED:20210325T212134Z
UID:13471-1621611000-1621611000@www.chemistry.ucla.edu
SUMMARY:Chem 268:  Nicole Lynn
DESCRIPTION:Torres Group \n“Functional characterization of the mammalian family of Katanin microtubule-severing enzymes”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-nicole-lynn/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210520T120000
DTEND;TZID=America/Los_Angeles:20210520T120000
DTSTAMP:20260615T085804
CREATED:20210513T152611Z
LAST-MODIFIED:20210513T152611Z
UID:13496-1621512000-1621512000@www.chemistry.ucla.edu
SUMMARY:Mechanism-guided discovery of photocontrolled materials and reactions
DESCRIPTION:Abstract: The Kalow lab interrogates and exploits the relationship between molecular reactivity and macroscopic properties to discover polymeric materials relevant to human health and sustainability. We approach “reactivity-property” relationships bidirectionally: in reactivity-directed materials discovery\, we use synthesis and physical organic chemistry to tune reactions occurring within polymer networks. In polymer networks composed of reversible covalent bonds\, we translate changes in reactivity into macroscopic responses\, ranging from repair in self-healing elastomers to photocontrolled stiffness in adaptable hydrogels. In properties-directed reaction discovery\, we design photochemical reaction mechanisms that target desirable photophysical properties. Based on this principle\, we have discovered a catalyst-free photopolymerization to produce n-type π-conjugated polymers\, and a selective photoinduced cross-coupling of polyhalogenated dyes. Across these projects\, light provides precise\, tunable\, and noninvasive spatiotemporal control over molecular reactivity.
URL:https://www.chemistry.ucla.edu/seminars/mechanism-guided-discovery-photocontrolled-materials-and-reactions/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210520T120000
DTEND;TZID=America/Los_Angeles:20210520T120000
DTSTAMP:20260615T085804
CREATED:20210331T173201Z
LAST-MODIFIED:20210331T173201Z
UID:13484-1621512000-1621512000@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Andrew Dawson
DESCRIPTION:Enabling High Capacity Anodes and Cathodes for Li-Ion Batteries
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-andrew-dawson/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210519T160000
DTEND;TZID=America/Los_Angeles:20210519T160000
DTSTAMP:20260615T085804
CREATED:20210324T211144Z
LAST-MODIFIED:20210324T211144Z
UID:13464-1621440000-1621440000@www.chemistry.ucla.edu
SUMMARY:Chem 278 Prof. Diaconescu Research Group Seminar
DESCRIPTION:Ruxi Dai  “Redox switchable catalysts for the preparation of biodegradable copolymers with novel properties”  \nAmy Lai  “Predicting redox-switchable reactivity for the ring opening polymerization of lactones and epoxides” 
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-diaconescu-research-group-seminar/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210518T160000
DTEND;TZID=America/Los_Angeles:20210518T160000
DTSTAMP:20260615T085804
CREATED:20210512T231308Z
LAST-MODIFIED:20210512T231308Z
UID:13495-1621353600-1621353600@www.chemistry.ucla.edu
SUMMARY:Synthetic polypeptide-based materials for biological applications
DESCRIPTION:Abstract: As more attention is focused on biomaterials for medical applications\, synthetic polypeptides offer a useful approach towards designing novel biomimetic materials. Polypeptides are inherently biodegradable and biocompatible\, and offer wide-ranging properties seen in living systems. The peptide backbone is enzymatically degradable while their side chain functionality can be modified to create an array of stimuli-responsive materials. Here\, I will present work on unnatural amino acids incorporated into synthetic polypeptides to design new biomaterials\, including vesicles\, hydrogels\, and coacervates. Synthesis of these materials are modular and can be processed into an assortment of self-assembled macromolecular structures through secondary structure and self-assembly\, relevant for stem cell therapies\, gene and protein therapeutics\, and imaging guides\, among many other biomedical applications.
URL:https://www.chemistry.ucla.edu/seminars/synthetic-polypeptide-based-materials-biological-applications/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210517T160000
DTEND;TZID=America/Los_Angeles:20210517T160000
DTSTAMP:20260615T085804
CREATED:20210323T205854Z
LAST-MODIFIED:20210323T205854Z
UID:13456-1621267200-1621267200@www.chemistry.ucla.edu
SUMMARY:Chem 228: Prof. Suzanne E. Paulson
DESCRIPTION:“Aerosol particles out in the world: Wildfire smoke\, traffic hotspots\, SARS CoV-19\, & Cloud droplet chemistry.”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-prof-suzanne-e-paulson/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210514T160000
DTEND;TZID=America/Los_Angeles:20210514T160000
DTSTAMP:20260615T085804
CREATED:20210325T211745Z
LAST-MODIFIED:20210325T211745Z
UID:13470-1621008000-1621008000@www.chemistry.ucla.edu
SUMMARY:Chem 268: Samuel Demario
DESCRIPTION:Chanfreau Group \n“Substrate specificity of the Yeast TRAMP complex”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-samuel-demario/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210513T130000
DTEND;TZID=America/Los_Angeles:20210513T130000
DTSTAMP:20260615T085804
CREATED:20210506T222050Z
LAST-MODIFIED:20210506T222050Z
UID:13494-1620910800-1620910800@www.chemistry.ucla.edu
SUMMARY:CIC Careers in Green Chemistry Seminar Series
DESCRIPTION:The Center for Integrated Catalysis is hosting a new seminar series called the “Careers in Green Chemistry.” With these webinars\, we aim to bring speakers from a wide variety of careers\, linked through green chemistry\, to come talk about their current job as well as the career path that led them to that position. We are pleased to invite all students\, postdocs\, and faculty.
URL:https://www.chemistry.ucla.edu/seminars/cic-careers-green-chemistry-seminar-series-0/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210513T120000
DTEND;TZID=America/Los_Angeles:20210513T120000
DTSTAMP:20260615T085804
CREATED:20210331T173043Z
LAST-MODIFIED:20210331T173043Z
UID:13483-1620907200-1620907200@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Erin Avery
DESCRIPTION:Exploration of Chemical Functionality of Self-Assembled Carborane Derivatives
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-erin-avery/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210513T120000
DTEND;TZID=America/Los_Angeles:20210513T120000
DTSTAMP:20260615T085804
CREATED:20210329T185640Z
LAST-MODIFIED:20210329T185640Z
UID:13480-1620907200-1620907200@www.chemistry.ucla.edu
SUMMARY:Synthesis in a Boron World
DESCRIPTION:Abstract: Nature has evolved highly sophisticated machinery for organic synthesis\, many of which resemble molecular assembly-line processes. So far chemists have been able to apply this type of approach in the synthesis of peptides and oligonucleotides but in these reactions\, simple amide (C‒N) or phosphate (P‒O) bonds are created. It is much more difficult to make C‒C bonds but this is central to the discipline of organic synthesis. This difficulty is why organic synthesis is challenging and why robust\, iterative or automated methodologies have not yet emerged. \nHere\, we describe the application of iterative homologation of boronic esters using chiral lithiated carbamates and chloromethyllithium enabling us to grow carbon chains with control over both relative and absolute stereochemistry. Applications of this strategy to the synthesis of natural products will be demonstrated. In addition\, the methodology is used to answer fundamental questions about nature and the specific role of methyl substituents in carbon chains. By understanding their role\, I will show that molecules can be created with linear or helical conformations or hybrids of the two. \nFinally\, I will show new triggers for 1\,2-metalate rearrangements of boronate complexes using strain release as an additional driving force and we use this chemistry to make functionalized cyclobutanes and azetidines.
URL:https://www.chemistry.ucla.edu/seminars/synthesis-boron-world/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210512T160000
DTEND;TZID=America/Los_Angeles:20210512T160000
DTSTAMP:20260615T085804
CREATED:20210323T222957Z
LAST-MODIFIED:20210323T222957Z
UID:13463-1620835200-1620835200@www.chemistry.ucla.edu
SUMMARY:OCDS Seminar: Prof. Rodney D. Priestley
DESCRIPTION:“Molecular Dynamics and Glass Formation of Nanoscopically Confined Polymer” \nMany technological advances are driven by the ongoing emergence of nanostructured polymers as the critical component to enable innovation. Yet\, from a materials design perspective\, we cannot presume that the bulk properties of polymers define their behavior when physically confined to nanoscale dimensions. This is\, in fact\, not true\, as there is now convincing evidence that the nanoscale properties of polymers\, including the glass transition temperature\, can be profoundly different from the bulk. Here\, I discuss two overarching questions in the field: 1) What are the molecular dynamics at the free surface of polymer glasses? and 2) How can we overcome the effect of confinement on the reduction in the glass transition temperature? Regarding the first question\, we introduce a time-resolved nano-creep experiment to probe the dynamics at the surface of polymer glasses. We reveal a new mode of molecular dynamic at the surface: pseudoentanglements. This phenomenon causes unentangled chains to exhibit surface mechanical response and dynamics that are characteristic of entangled polymers. For entangled chains\, the phenomenon prolongs and stiffens the entangled response. In both cases\, the breadth of the entangled response grows on cooling\, leading to a breakdown of time-temperature-superposition at the surface. Counterintuitively\, this new mode of slow surface dynamics emerges precisely because surface dynamics are accelerated relative to the bulk. Concerning the latter question\, we demonstrate that ultrathin polymer films with an ultradense brush morphology – defined with respect to approaching the maximum theoretical value of crystalline chain packing – exhibits a significant enhancement in thermal stability\, as manifested by an exceptionally high Tg and low expansivity. For instance\, a 5 nm thick polystyrene brush film exhibits a ~ 75 K increment in Tg and ~ 90 % reduction in expansivity compared to a spin-cast film of comparable thickness. Our results establish how the film morphology can overcome confinement and interfacial effects in controlling material properties\, and how this can be achieved by the dense packing and molecular ordering in the amorphous state of the ultradense brushes prepared by surface-initiated atom transfer radical polymerization in combination with a self-assembled monolayer of initiators.
URL:https://www.chemistry.ucla.edu/seminars/ocds-seminar-prof-rodney-d-priestley/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210511T160000
DTEND;TZID=America/Los_Angeles:20210511T160000
DTSTAMP:20260615T085804
CREATED:20210401T175814Z
LAST-MODIFIED:20210401T175814Z
UID:13487-1620748800-1620748800@www.chemistry.ucla.edu
SUMMARY:Synthetic biology approaches to study and exploit RNA regulation
DESCRIPTION:Abstract: RNA transcribed from the genome in the nucleus bears little resemblance to the RNA polymer it will ultimately become in the cytoplasm where it is translated into protein. Well-known processes such as capping\, splicing and polyadenylation\, as well as the recently discovered and ever-expanding list of diverse chemical modifications and editing\, significantly alter the properties and fates of a given RNA during the course of its lifetime. These alterations regulate critical aspects of RNA function such as stability\, transport\, protein binding\, and translation. Especially in mammalian systems\, these post-transcriptional gene expression regulatory processes are often a key determinant of genetic information flow. Moreover\, from an engineering and therapeutic perspective these RNA regulatory processes represent new ways to control or retune gene expression at the RNA level\, if they can be harnessed. I will present several technologies our group has developed to measure the chemical composition and localization of RNAs\, and to measure and control protein-RNA interactions with an eye toward therapeutic development.
URL:https://www.chemistry.ucla.edu/seminars/synthetic-biology-approaches-study-and-exploit-rna-regulation/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210511T130000
DTEND;TZID=America/Los_Angeles:20210511T130000
DTSTAMP:20260615T085804
CREATED:20210428T180058Z
LAST-MODIFIED:20210428T180058Z
UID:13493-1620738000-1620738000@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday\, May 11th\, 2021 at 1:00 PM. We are pleased to invite all students\, postdocs\, faculty\, and staff.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-7/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210510T160000
DTEND;TZID=America/Los_Angeles:20210510T160000
DTSTAMP:20260615T085804
CREATED:20210323T204709Z
LAST-MODIFIED:20210323T204709Z
UID:13455-1620662400-1620662400@www.chemistry.ucla.edu
SUMMARY:Chem 228: Prof. Andreas Heinrich
DESCRIPTION:“Taking Electron Spin Resonance to the Single Atom and Molecule”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-prof-andreas-heinrich/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210507T153000
DTEND;TZID=America/Los_Angeles:20210507T153000
DTSTAMP:20260615T085804
CREATED:20210325T211452Z
LAST-MODIFIED:20210325T211452Z
UID:13469-1620401400-1620401400@www.chemistry.ucla.edu
SUMMARY:Chem 268: Hannah Bailey
DESCRIPTION:Quinlan Group \n“Utilizing Drosophila melanogaster to understand the role of actin dynamics in oogenesis”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-hannah-bailey/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210506T160000
DTEND;TZID=America/Los_Angeles:20210506T160000
DTSTAMP:20260615T085804
CREATED:20210329T185010Z
LAST-MODIFIED:20210329T185010Z
UID:13479-1620316800-1620316800@www.chemistry.ucla.edu
SUMMARY:Strain molecules assist peptide and protein synthesis\, a new venue for thiolactones
DESCRIPTION: Abstract: The broad application of macrocycles has illustrated significant potential as therapeutic agents. 12-membered ring cyclotetrapeptides are particularly attractive entities among all the cyclic peptides. Compared with macrocycles of larger ring size\, the characteristic head-to-tail or end-to-end peptidyl backbone provides intrusive structural motif of circular peptides grants distinct biological properties such as resistance to degradation\, enhanced conformational stability\, and increased epitope interactions with other biomolecules. Ability to acquire a sufficient quantity of high purity of cyclo-tetrapeptide could significantly promote their chemical and biological studies. \nIt is worth noting that the traditional coupling methods to achieve chemical synthesis of macrocycles have been a formidable challenge\, requiring fully protected linear precursors and harsh conditions to achieve activation of the C-terminal residue for the cyclization. The harsh activation conditions are required to overcome the entropy barrier during the coupling often lead to epimerization of the C-terminal amino acid residue and peptide oligomerization. The practical strategy to attain macrocycles with a consensus sequence of L-cyclo(Pro-Xxx-Pro-Xxx)\, where Xxx = Val\, Tyr\, Leu\, Phe\, are elusive. There is the urgent need to develop a strategy to prepare circular tetrapeptides. Based on our previously reported β-thiolactone mediated chemistry\, iii we were able to construct tetra-cyclic peptides in high yields. The strategy could be applied to produce a broad number of all-L-cyclo-tetrapeptides and the reactions were performed at room temperature in the aqueous buffer. The β-thiolactone furnished cyclization protocol prevented the amino acid epimerization during the cyclization and proved as a powerful general strategy for cyclic peptide synthesis.
URL:https://www.chemistry.ucla.edu/seminars/strain-molecules-assist-peptide-and-protein-synthesis-new-venue-thiolactones/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210506T120000
DTEND;TZID=America/Los_Angeles:20210506T120000
DTSTAMP:20260615T085804
CREATED:20210331T172442Z
LAST-MODIFIED:20210331T172442Z
UID:13482-1620302400-1620302400@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Jack Fuller
DESCRIPTION:Secondary Coordination Effects in Artificial Biotin-Streptavidin Metalloenzymes \n Designing artificial metalloenzymes is of interest because they combine the catalytic activity of possibly non-physiological but highly catalytically potent metals and the selectivity and mild operational conditions enabled by the protein. This talk will focus on joint theory-experiment efforts to design Rh and Ir artificial metalloenzymes\, catalyzing the formation of 5-membered and 6-membered N-heterocycles. The biotin-streptavidin system has been used as a relatively simple and robust platform to create metalloenzymes by embedding organometallic catalysts in the protein. The monomeric streptavidin is known to retain the fold upon many different mutations\, thus enabling the control over the second coordination sphere of the metal and fine-tuning of the metal electronic properties in a variety of ways without losing the entire structure. Biotin-Sav artificial metalloenzymes prepared in this way and containing Rh/Ir(Cp*) have shown improved reactivity and selectivity over simpler organometallic catalysts. We aimed to both explain the improved activity and to enhance it further by strategic mutagenesis. We have analyzed the secondary coordination effects using quantum mechanistic calculations\, bonding analysis\, and hybrid quantum mechanical/molecular mechanical simulations. In collaboration with experiment\, we probed a library of mutants. In particular\, we show that the pi-pi interaction between the catalyst and a tyrosine sidechain decreases rate-determining barriers. Additional residues in the vicinity of Tyr contribute to the quality of the pi-pi contact and the reactivity tuning. More remote mutations within the protein scaffold affect the protein structure and dynamics slightly\, and thus affect the pi-pi contact indirectly\, also impacting the activity. Successful and failed strategic and accidental mutations were made with the goal of improving the pi-pi contact\, and will be discussed. Finally\, we demonstrated that the activity correlates the most with the properties of the ensemble of states within the protein dynamics\, showcasing the need for rapid QM/MM sampling in this work.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-jack-fuller/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210505T160000
DTEND;TZID=America/Los_Angeles:20210505T160000
DTSTAMP:20260615T085804
CREATED:20210323T222542Z
LAST-MODIFIED:20210323T222542Z
UID:13462-1620230400-1620230400@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Henry S. La Pierre
DESCRIPTION:“Electron (De) Localization in f-Element Systems: From Fundamental Questions to QIS Design Principles” \n Abstract: The La Pierre group studies how collective magnetic\, physical\, and chemical properties arise from electron (de)localization phenomena in f-element systems. Our studies include the development of solid-state and solution methodologies for the synthesis of novel lanthanide and actinide (Th – Pu) materials and complexes. These synthetic efforts are paired with synchrotron and neutron spectroscopies and physical property studies to break down the challenge of understanding the electronic structure of f-element systems. Particularly in solid-state systems\, the f-elements present unique valence electronic structures due the near degeneracies engendered in these systems and strong electron correlation. Our efforts to-date have focused on the synthesis and analysis of systems governed by one of three phenomena: magnetic super-exchange (i.e. exchange coupled systems)\, multi-configurational electronic structures (ground state degeneracy including hybridization with ligand/band states)\, and mixed-valence metal ions (i.e. mixed f/d occupancy and mixed-oxidation states). Understanding and controlling the manifestation of these phenomena in molecular systems is crucial for understanding the interplay of these phenomena underpinning topological insulators such as SmB6 and PuB6 and superconductors such as CeCoIn5 and PuCoGa5. In turn\, the group has employed this expanded fundamental understanding of f-element electronic structure to construct components of quantum information technologies (e.g. qubits\, single-molecule magnets).
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-henry-s-la-pierre/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210504T160000
DTEND;TZID=America/Los_Angeles:20210504T160000
DTSTAMP:20260615T085804
CREATED:20210330T185400Z
LAST-MODIFIED:20210330T185400Z
UID:13481-1620144000-1620144000@www.chemistry.ucla.edu
SUMMARY:Molecular recognition tools for chemistry in living systems
DESCRIPTION:Abstract: The introduction of unnatural functionality in biological systems coupled with detection using bioorthogonal chemical reactions revolutionized the field of chemical biology by enabling the investigation biological processes in live cells and simple organisms. However the translation to complex organisms has led to less than optimal results with high background noise due to cross reactivity with activated reagents. This work investigates the utilization of non-covalent chemistry and bioorthogonal host-guest pairs to obtain more efficient labeling of living systems. Complexation between a host and guest is diffusion-limited\, hence can be efficient in dilute environments. The cucurbit[n]uril scaffold has been utilized to determine the minimum binding affinity required for efficient bioorthogonal complexation and investigate how guest size and charge affects the introduction of guests as unnatural metabolites. Carboranes\, a cucurbit[7]uril guest class that can be removed “on demand” from the host cavity\, were found compatible with metabolic glycoengineering and were successfully incorporated on the cell surface. The cucurbit[7]uril-carborane system serves as the first example of bioorthogonal complexation and answers fundamental questions required for the further development of bioorthogonal host-guest pairs.
URL:https://www.chemistry.ucla.edu/seminars/molecular-recognition-tools-chemistry-living-systems/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210503T160000
DTEND;TZID=America/Los_Angeles:20210503T160000
DTSTAMP:20260615T085804
CREATED:20210323T204542Z
LAST-MODIFIED:20210323T204542Z
UID:13454-1620057600-1620057600@www.chemistry.ucla.edu
SUMMARY:OCDS Seminar: Prof. Markita Landry
DESCRIPTION:“Nanomaterials Enable Delivery of Genetic Material Without TransgeneIntegration in Mature Plants”
URL:https://www.chemistry.ucla.edu/seminars/ocds-seminar-prof-markita-landry/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210430T153000
DTEND;TZID=America/Los_Angeles:20210430T153000
DTSTAMP:20260615T085804
CREATED:20210415T233542Z
LAST-MODIFIED:20210415T233542Z
UID:13490-1619796600-1619796600@www.chemistry.ucla.edu
SUMMARY:Chem 268: Sean D. Gallaher and Einav Tayeb-Fligelman
DESCRIPTION:Sean D. Gallaher\, Ph.D.      \nMerchant Group \n“Prokaryotic-style polycistronic gene expression in eukaryotic green algae” \n~and~ \nEinav Tayeb-Fligelman\, Ph.D.     \nEisenberg Group \n“Modulation of Amyloid Formation of the Nucleoprotein of SARS-CoV-2”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-sean-d-gallaher-and-einav-tayeb-fligelman/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210429T160000
DTEND;TZID=America/Los_Angeles:20210429T160000
DTSTAMP:20260615T085804
CREATED:20210329T184445Z
LAST-MODIFIED:20210329T184445Z
UID:13478-1619712000-1619712000@www.chemistry.ucla.edu
SUMMARY:New Synthetic Opportunities through Organic Photocatalysis”
DESCRIPTION:Abstract: Development of new synthetic strategies via organic photocatalysis in our group was described. Both photoacidic activity and photoredox activity of organic photocatalysts were discussed. A series of phenol-conjugated acridinium-based organic photoacids were rationally designed\, synthesized and studied alongside commercially available phenolic catalyst\, eosin Y. In the presence these photoacid catalysts and light\, synthetic glycals underwent activation and coupled with a range of alcohols to afford 2-deoxy-glycosides in good yields with excellent a-selectivity. Moreover\, a recent development of photo Lewis acid catalyst was described. In addition\, a photocatalytic N-radical cascade reactions were discussed\, including synthesis of pyrroloindolines\, rapid synthesis of flustramide B\, and remote allylation of uncativated sp3 C-H bonds.
URL:https://www.chemistry.ucla.edu/seminars/new-synthetic-opportunities-through-organic-photocatalysis/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210429T120000
DTEND;TZID=America/Los_Angeles:20210429T120000
DTSTAMP:20260615T085804
CREATED:20210422T205449Z
LAST-MODIFIED:20210422T205449Z
UID:13492-1619697600-1619697600@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Peiqi Wang
DESCRIPTION:“Van der Waals Integration beyond 2D Heterostructures” \n Abstract: The integration of dissimilar materials to form heterostructures with designable electronic interfaces is central in modern electronic devices and has thus been a long pursuit in material science. The traditional integration methods such as metal evaporation\, atomic layer deposition (ALD) and epitaxial growth typically rely on strong chemical bonds to combine the constituent materials. However\, this approach has limited freedom in integrating materials with distinct structural or chemical compositions due to the lattice matching or process compatibility requirements. Inspired by the variety of 2D van der Waals (vdW) heterostructures\, a physical transfer process exploiting the universal vdW force is proposed for damage-free integration of metal contact and 2D semiconductors to form pinning-free junctions approaching Schottky-Mott limit\, opening up vast freedom for creating a new generation of vdW-integrated devices beyond the reach of traditional heterostructures. This talk summarizes our recent progress of vdW integration of high-quality contacts of nearly arbitrary metals\, gate dielectrics and bulk semiconductors to create high-performance devices including 2D metal-oxide-semiconductor field-effect transistors (MOSFETs)\, metal-semiconductor FETs (MESFETs) and junction FETs (JFETs) based on bulk semiconductor β-Ga2O3\, which all exhibit atomically clean and electronically sharp interfaces with nearly ideal electronic functions. These devices extend vdW integration to a broader library of materials for creating high-performance electronic devices and explore the potential of vdW integration as a general and efficient approach for circuit-level integration.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-peiqi-wang/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210428T160000
DTEND;TZID=America/Los_Angeles:20210428T160000
DTSTAMP:20260615T085804
CREATED:20210323T222021Z
LAST-MODIFIED:20210323T222021Z
UID:13461-1619625600-1619625600@www.chemistry.ucla.edu
SUMMARY:Chem 278 Prof. Liu Research Group Seminar
DESCRIPTION:“Enhanced Gas Transport in Hybrid Bio-Inorganic CO2 and N2 Fixation Systems” \n Abstract: With the surge of intermittent\, renewable electricity\, the storage of excessive electricity and reduction of CO2 or N2 into value-added chemicals is of great significance for a sustainable society. One viable route is to construct a hybrid inorganic-biological system that converts electricity into chemical energy and reduces CO2/N2 into commodity chemicals. In this general approach\, water is electrochemically split into H2 and O2 and the yielded H2 is consumed by microbes as a reducing equivalent for CO2/N2 reduction. This system has demonstrated high efficiencies however\, the output of the commodity chemicals is limited by the supply of the reducing equivalent\, H2\, within the system. While we can electrochemically control the rate of H2 production\, the poor solubility of H2 in the aqueous environment results in a bottleneck. Here\, we demonstrate the addition of perfluorocarbon (PFC) nanoemulsions to increase H2 solubility and improve the kinetic rate of gas transport to the microbes for enhanced chemical production. With PFC nanoemulsions applied to our hybrid CO2 fixation system\, we maintained nearly 100% Faradaic efficiency over a range of applied current densities and increased the throughput 2.9 times at 2.0 mA/cm2. Similarly\, by adding varying percentages of PFC nanoemulsion to our N2 fixation system we were able to control the H2 and O2 concentrations in solution and enhance N2 fixation. Overall\, our research demonstrates the use of PFC nanoemulsions to enhance gas solubility and gas transport in aqueous solution for favorable reaction conditions and improved rates of chemical production.
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-liu-research-group-seminar/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
END:VCALENDAR