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X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
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DTSTART:20220313T100000
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DTSTART:20221106T090000
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230206T090000
DTEND;TZID=America/Los_Angeles:20230206T100000
DTSTAMP:20260614T080436
CREATED:20230130T193501Z
LAST-MODIFIED:20230130T194133Z
UID:27940-1675674000-1675677600@www.chemistry.ucla.edu
SUMMARY:Norma Stoddart Prize - Grad Student Q&A with Sir Fraser Stoddart
DESCRIPTION:9:00 AM – 10:00 AM \nGrad Student Q&A with Nobel Laureate Sir Fraser Stoddart \nNorma Stoddart Prize Flyer – Dr. Marco Messina
URL:https://www.chemistry.ucla.edu/events/norma-stoddart-prize-grad-student-qa-with-sir-fraser-stoddart/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Norma Stoddart
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230203T153000
DTEND;TZID=America/Los_Angeles:20230203T163000
DTSTAMP:20260614T080436
CREATED:20221214T003714Z
LAST-MODIFIED:20230127T212037Z
UID:26850-1675438200-1675441800@www.chemistry.ucla.edu
SUMMARY:Biochemistry Seminar Series - Prof. Zhipeng Lu
DESCRIPTION:Flyer: Zhipeng Lu Flyer \nTitle: What does RNA look like in cells? Structures\, interactions and modifications. \nAbstract: RNA in living cells are in constant motion\, form dynamic structures\, and interact with many molecules\, including other RNAs. Direct determination of RNA structures and interactions in vivo is essential to understanding their functions\, and developing new RNA-based and RNA-targeting therapeutics\, but has been challenging in the past. We developed a number of novel chemical and computational tools to capture the 2D and 3D RNA structurome and interactome in cells\, providing a comprehensive view of RNA conformations that underlie their roles in gene regulation and human diseases. In particular\, our recent applications of these methods revealed new mechanisms in lncRNA functions and RNA modifications.
URL:https://www.chemistry.ucla.edu/seminars/biochemistry-seminar-series-prof-zhipeng-lu/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230202T160000
DTEND;TZID=America/Los_Angeles:20230202T170000
DTSTAMP:20260614T080436
CREATED:20221201T185038Z
LAST-MODIFIED:20221201T185038Z
UID:26550-1675353600-1675357200@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Zachary Wickens
DESCRIPTION:Prof. Wickens Flyer \nSelective Synthesis via Light and Electricity \nAbstract: We are investigating how organic radical ions–typically thought of as fleeting intermediates–can be tamed and exploited as a new family of organocatalysts and small molecule reagents. We identified selective generation of such species as a key hurdle stymying exploration these electronically-destabilized systems. To address this problem\, we have leveraged electrochemistry to develop new synthetic transformations driven by organic radical ions. Electrochemistry offers not only an environmentally benign approach to promote redox events but also substantially simplifies the study of these unusual systems by enabling the exclusion of byproducts from oxidation or reductive generation of the key radical ion promoters. \nThis seminar will describe two new platforms for synthetic reaction development based on electrogenerated persistent organic radical ions. In the first system\, we describe the development of a new family of radical anion photoredox catalysts over a volt more reducing than conventional photocatalyst systems. These potent catalysts have enabled abundant but classes of arene substrates to now act as general aryl radical precursors for diverse radical coupling reactions. In the second system\, we will discuss a new approach to oxidatively functionalize alkenes via a metastable dielectrophilic intermediate derived from reaction with thianthrene radical cation. This strategy has enabled new synthetic methods to construct high value aliphatic amine products by coupling amines and feedstock hydrocarbons.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-zachary-wickens/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230131T160000
DTEND;TZID=America/Los_Angeles:20230131T170000
DTSTAMP:20260614T080436
CREATED:20230107T033823Z
LAST-MODIFIED:20230123T183303Z
UID:27096-1675180800-1675184400@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Soumitra Athavale
DESCRIPTION:Tales in Molecular Evolution:  From Chiral Symmetry Breaking to New-to-Nature Biocatalysis \n\nThe evolutionary journey of chemistry on our planet\, from small molecules to genetic polymers\, presents fascinating opportunities for the organic chemist. At one end\, mysterious early steps evoke grand questions at the foundations of chemistry\, while at the other\, biology’s extraordinary machinery lies primed for creative manipulation.   \nAn illustration of the former is the riddle of the origin of biological homochirality\, inspiring the general query\, ‘can asymmetric synthesis transpire without any chiral intervention’? The Soai reaction – diisopropylzinc alkylation of pyrimidine carbaldehydes – remains a singular\, celebrated example where this is possible and has received widespread attention from diverse chemical fields. I will present structural\, experimental\, and computational investigations which reveal the first comprehensive mechanistic picture of this iconic transformation.  \nFor the latter case\, I will showcase how the principles of directed evolution can be applied to develop new enzymes for promoting processes never seen in nature. The engineering of heme proteins enables enantioselective catalysis of challenging nitrene C–H insertion reactions for accessing nitrogen containing compounds from feedstock chemicals. This example of ‘new-to-nature biocatalysis’ is emblematic of a modern age of protein biochemistry that promises to revolutionize the use of enzymes for molecular construction.  
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-soumitra-athavale/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230130T160000
DTEND;TZID=America/Los_Angeles:20230130T170000
DTSTAMP:20260614T080436
CREATED:20230113T213541Z
LAST-MODIFIED:20230113T213541Z
UID:27153-1675094400-1675098000@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: Dolores Bozovic
DESCRIPTION:Prof. Bozovic Flyer \nTitle: Physics of the Auditory System \nAbstract: Hair cells of the auditory system constitute a remarkable biological sensor that exhibits nanometer-scale sensitivity of mechanical detection. Our experiments explore the active nonlinear processes behind the detection of very weak signals. We demonstrate the presence of chaos in the innate motility of active bundles\, and explore both theoretically and experimentally its role in enhancing the sensitivity of detection. We further show that these cells utilize weakly chaotic dynamics to combine sensitive response with high temporal resolution. The presence of chaos in individual hair bundles also aids in the synchronization between coupled hair cells\, and gives rise to new dynamical states. Finally\, we explore the neural mechanisms that reduce and control the responsiveness of the cell. Specifically\, we show that the efferent neurons serve as a gain control system\, which can strongly affect the very compliance of the mechanosensory cells. \n 
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-dolores-bozovic/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230130T150000
DTEND;TZID=America/Los_Angeles:20230130T155000
DTSTAMP:20260614T080436
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213627Z
UID:24061-1675090800-1675093800@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Georgia Scherer
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-01-30/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230130T110000
DTEND;TZID=America/Los_Angeles:20230130T120000
DTSTAMP:20260614T080436
CREATED:20221215T220432Z
LAST-MODIFIED:20221215T220432Z
UID:26930-1675076400-1675080000@www.chemistry.ucla.edu
SUMMARY:Special Biochem Seminar - Jie Zhou
DESCRIPTION:Title: Identify and Target Proteolytic Neoepitopes in Cancer
URL:https://www.chemistry.ucla.edu/events/special-biochem-seminar-jie-zhou/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230127T130000
DTEND;TZID=America/Los_Angeles:20230127T141500
DTSTAMP:20260614T080436
CREATED:20221215T194029Z
LAST-MODIFIED:20230110T224808Z
UID:26914-1674824400-1674828900@www.chemistry.ucla.edu
SUMMARY:Special Inorganic Chemistry Seminar Series: Agnes Thorarinsdottir
DESCRIPTION:Flyer: Dr. Agnes Thorarinsdottir flyer \nTitle: New Approaches to Magnetic Resonance Imaging and Energy Catalysis Through Chemical Design \nAbstract: Synthetic chemistry is a powerful tool for realizing molecules and materials with novel functions for addressing grand challenges in biomedical\, environmental\, and energy science. This presentation will discuss two avenues by which specific molecular and materials functions may be implemented by chemical design to create chemical systems with advanced properties. \nPart 1: Variation of properties such as temperature\, pH\, and redox status in the tissue microenvironment is closely associated with a number of biological processes and diseases. Magnetic resonance imaging (MRI) probes that can alter their magnetic properties in response to specific changes in their surrounding environment provide new opportunities for overcoming the current limitations of traditional MRI contrast agents\, namely relatively low sensitivity and poor specificity. This presentation will describe the employment of spin-crossover iron complexes for monitoring temperature using 19F NMR chemical shift and dinuclear cobalt complexes for the ratiometric quantitation of solution pH in a noninvasive manner. \nPart 2: Global adoption of sustainable energy technologies and chemical industries relies heavily on the efficiency by which small gas molecules such as CO2\, N2\, O2\, and H2 can be converted to fuels\, chemicals\, and electricity. Electrocatalysis of such gas molecules driven by renewable energy sources offers a promising route\, however\, performing such reactions in aqueous environments has been limited by the low solubilities of gases in water. This presentation will describe a strategy of harnessing the high gas capacities of microporous water—aqueous porous liquids comprising microporous nanocrystals—for engendering current enhancement in the electroreduction of O2 in water.
URL:https://www.chemistry.ucla.edu/seminars/special-inorganic-chemistry-seminar-series-agnes-thorarinsdottir/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Inorganic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230126T160000
DTEND;TZID=America/Los_Angeles:20230126T170000
DTSTAMP:20260614T080436
CREATED:20221215T195221Z
LAST-MODIFIED:20221215T195221Z
UID:26918-1674748800-1674752400@www.chemistry.ucla.edu
SUMMARY:Distinguished Lecture Series: Daniel G. Nocera
DESCRIPTION:Flyer TBA \nTitle TBA \nAbstract TBA
URL:https://www.chemistry.ucla.edu/events/distinguished-lecture-series-daniel-g-nocera/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Distinguished Lecture Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230125T160000
DTEND;TZID=America/Los_Angeles:20230125T171500
DTSTAMP:20260614T080436
CREATED:20221215T193726Z
LAST-MODIFIED:20230110T224913Z
UID:26910-1674662400-1674666900@www.chemistry.ucla.edu
SUMMARY:Jeffrey I. Zink Inorganic Chemistry Seminar Series: Elena Meirzadeh
DESCRIPTION:Flyer: Dr. Elena Meirzadeh Flyer \nTitle: From small molecules to infinite superatomic sheets \nAbstract: Developing a precise understanding of structure-function relationships in molecular crystals can allow us to generate a wide range of properties from extremely simple building blocks. In the first half of my talk\, I will discuss how crystal engineering and defects affect the macroscopic properties of amino acid crystals. Moreover\, I will describe the molecular-level determination of the structure of defect sites\, which are below the diffraction detection limit\, using pyroelectric measurement coupled with dispersion-corrected density functional theory calculations and molecular dynamics simulations. In the second half of my talk\, I will introduce a new two-dimensional crystalline form of carbon that we recently synthesized –– graphullerene. The constituent fullerene subunits in these crystals are arranged hexagonally in a covalently interconnected molecular sheet that can be mechanically exfoliated and characterized. I will describe how the properties of graphullerene differ from those of graphene and molecular fullerenes.
URL:https://www.chemistry.ucla.edu/seminars/jeffrey-i-zink-inorganic-chemistry-seminar-series-elena-meirzadeh/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Inorganic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230124T160000
DTEND;TZID=America/Los_Angeles:20230124T170000
DTSTAMP:20260614T080436
CREATED:20230107T033525Z
LAST-MODIFIED:20230107T033525Z
UID:27094-1674576000-1674579600@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Dr. Jose Roque
DESCRIPTION:Modern drug discovery has benefited from advancements in chemical reaction development. For example\, C–H functionalization reactions has transformed how synthetic chemists approach the retrosynthetic analysis of bioactive compounds. Despite recent advances\, the development of site-selective reactions remains a grand challenge in metal-catalyzed C–H functionalization. Typical retrosynthetic analysis results in simplified fragments by the removal of functional groups on the periphery of molecules. As a result\, forward syntheses and diversification of molecules have focused on peripheral modifications. Inspired by the concept of scaffold hopping\, the first part of the presentation will detail an approach to access novel chemical space by focusing on making structural edits to the core framework of molecules. The second part of the presentation will center on addressing site-selectivity and the need for more active first-row transition metal catalysts\, as the low activity and limited scope of known first-row transition metal catalysts severely limit their utility. Cobalt precatalysts supported by pyridine dicarbene pincers have been developed to selectively functionalize electronically distinct C–H bonds without relying on directing groups contrasting traditional approaches. For example\, the meta-selective C(sp2)–H borylation of fluoroarenes\, a significant challenge due to the weak coordinating ability and the similar size of fluorine and hydrogen\, has been demonstrated. Mechanistic studies on fluoroarene borylation established a kinetic preference for C–H bond activation at the meta position\, while cobalt-aryl complexes resulting from ortho C–H activation are thermodynamically preferred. As a result of these mechanistic insights\, the selectivity of a C–H borylation can be switched with a single catalyst by simply modifying the reaction conditions.
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-dr-jose-roque/
LOCATION:Young Hall 2033
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230124T130000
DTEND;TZID=America/Los_Angeles:20230124T143000
DTSTAMP:20260614T080436
CREATED:20221220T220043Z
LAST-MODIFIED:20221220T222155Z
UID:26961-1674565200-1674570600@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series: Parisa Mehrkhodavandi
DESCRIPTION:Title: Cationic indium in catalysis: Generation of functionalized copolymers from commodity monomers \nAbstract: Cationic indium complexes are rare in the field of catalysis. We have developed families of cationic indium complexes supported by tridentate and tetradentate aminophenolate ligands which show reactivity towards cyclic esters\, cyclic ethers\, and copolymerizations with CO 2. We show that\, depending on ligand design\, these complexes are excellent catalysts for the coupling of functionalized epoxides and cyclic esters to form orthoesters\, for the controlled ring opening polymerization of cyclic ethers\, and for the copolymerization of cyclic ethers and esters. Structure-function relationships and mechanistic considerations in each of these systems will be explored.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-for-integrated-catalysis-webinar-series-parisa-mehrkhodavandi/
CATEGORIES:Other,Seminars
LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230123T160000
DTEND;TZID=America/Los_Angeles:20230123T170000
DTSTAMP:20260614T080436
CREATED:20221222T224113Z
LAST-MODIFIED:20230110T221720Z
UID:26979-1674489600-1674493200@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry 228: Dr.  Milena Jovanovic
DESCRIPTION:Dr. Jovanovic Flyer \nTitle: “Delocalized Bonding in Extended Systems: From Molecules to Quantum Materials” \nAbstract: A long list of words attached to extensions of two-center two-electron bonding\, such as\nconjugation\, aromaticity\, electron-deficient\, and electron-rich bonding\, testifies to the ubiquity of\nelectron delocalization and its importance in chemistry. Delocalization certainly has consequences – in\nspectroscopic\, ionization\, and magnetic questions the most prominently – both for discrete molecules\nand for polymers and extended solids. Moreover\, a complex relationship between delocalized bonding\nand quantum properties of extended solids has come to light in recent years. Understanding\ndelocalization mechanisms and how they interact with each other is crucial to designing new quantum\nmaterials.\nMy talk focuses on two cases of electron delocalization in materials: σ delocalization in\npermethylated polysilane and chemical bonding in kagome lattices. In the case of permethylated\npolysilane\, I will explain how strong conformational dependence of the polymer’s properties arises from\nan interplay of two delocalization mechanisms. In the case of compounds featuring the kagome lattice\, I\nwill derive chemical rules to predict if bonding within the lattice is possible and its relation to materials’\nproperties. Additionally\, I will briefly reflect on the other aspects of electron delocalization\, namely non-\ntrivial election localization in crystals and its consequences.
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-228-dr-milena-jovanovic/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230123T150000
DTEND;TZID=America/Los_Angeles:20230123T155000
DTSTAMP:20260614T080436
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213523Z
UID:24060-1674486000-1674489000@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Madeline Ruos
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-01-23/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230120T153000
DTEND;TZID=America/Los_Angeles:20230120T163000
DTSTAMP:20260614T080436
CREATED:20221222T002730Z
LAST-MODIFIED:20221222T002730Z
UID:26972-1674228600-1674232200@www.chemistry.ucla.edu
SUMMARY:Dickerson Biochemistry Seminar Series: Prof. Sarah Keane
DESCRIPTION:Flyer: Sarah Keane Flyer \nTitle: Structure of pre-miR-31 reveals an active role in Dicer processing \nAbstract: As an essential post-transcriptional regulator of gene expression\, microRNA (miR) levels must be strictly maintained. The biogenesis of many\, but not all\, miRs is mediated by trans-acting protein partners through a variety of mechanisms\, including remodeling of the RNA structure. The intrinsic structural properties of RNAs can provide an additional layer of regulation. miR-31 functions as an oncogene in numerous cancers and interestingly\, its biogenesis is not known to be regulated by protein binding partners. We determined the solution structure of the precursor element of miR-31 (pre-miR-31) to investigate the role of distinct structural elements in regulating Dicer processing. We found that the presence or absence of mismatches within the helical stem do not strongly influence Dicer processing of the pre-miR. However\, both the apical loop size and structure at the Dicing site are key elements for discrimination by Dicer. Interestingly\, our NMR-derived structure reveals the presence of a triplet of base pairs that link the Dicer cleavage site and the apical loop. Mutational analysis in this region suggests that the stability of the junction region strongly influence both Dicer binding and processing. Our results enrich our understanding of the active role that RNA structure plays in regulating Dicer processing.
URL:https://www.chemistry.ucla.edu/seminars/dickerson-biochemistry-seminar-series-prof-sarah-keane/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230120T153000
DTEND;TZID=America/Los_Angeles:20230120T163000
DTSTAMP:20260614T080436
CREATED:20221214T003509Z
LAST-MODIFIED:20221214T003509Z
UID:26848-1674228600-1674232200@www.chemistry.ucla.edu
SUMMARY:Biochemistry Seminar Series - Prof. Sarah Keane
DESCRIPTION:Title: TBD \nAbstract: TBD
URL:https://www.chemistry.ucla.edu/seminars/biochemistry-seminar-series-prof-sarah-keane/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230119T160000
DTEND;TZID=America/Los_Angeles:20230119T170000
DTSTAMP:20260614T080436
CREATED:20221201T183346Z
LAST-MODIFIED:20221201T183346Z
UID:26546-1674144000-1674147600@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Tehshik Yoon
DESCRIPTION:Prof. Yoon Flyer \nStereocontrol in Photochemical Synthesis \nAbstract: Photochemistry is intriguing as a synthetic tool because the absorption of light by an organic molecule results in the formation of exceptionally energetic reactive intermediates that can react in ways that are inaccessible to ground-state molecules. However\, this high reactivity is also a challenge for stereoselective synthesis: control over the stereochemistry of photochemical reactions\, particularly using enantioselective catalysts\, has been a long-standing challenging synthetic problem with few general solutions. We recently developed a strategy that utilizes privileged chiral Brønsted acid scaffolds to control both the absolute and relative stereochemistry of complex [2+2] photocycloadditions. These reactions have enabled a general\, concise\, and stereocontrolled  strategy for the synthesis of the truxinate and truxillate natural products.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-tehshik-yoon/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230119T110000
DTEND;TZID=America/Los_Angeles:20230119T120000
DTSTAMP:20260614T080436
CREATED:20221215T220211Z
LAST-MODIFIED:20221215T220211Z
UID:26928-1674126000-1674129600@www.chemistry.ucla.edu
SUMMARY:Special Biochem Seminar - Alex Guseman
DESCRIPTION:Title: Targeting Spike Glycans to Inhibit Viral Entry
URL:https://www.chemistry.ucla.edu/events/special-biochem-seminar-alex-guseman/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230117T160000
DTEND;TZID=America/Los_Angeles:20230117T170000
DTSTAMP:20260614T080436
CREATED:20230107T032733Z
LAST-MODIFIED:20230107T032733Z
UID:27088-1673971200-1673974800@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Dr. Alistair Sterling
DESCRIPTION:Strain is a foundational concept in organic chemistry. Its presence can transform an inert molecule into one with exciting properties\, or steer a reaction toward a single product with exquisite control. Understanding—and importantly\, predicting—the delicate balance between strain and reactivity will enable the full potential of strain to be harnessed for drug discovery\, materials chemistry\, bioconjugation and beyond. In this talk\, efforts to uncover the fundamental principles that govern strain release chemistry will be discussed\, using the highly-strained hydrocarbon [1.1.1]propellane to develop the concept of bond delocalization\,1 before demonstrating how this idea can be generalized to predict the behaviour of all small-ring carbocycles.2 The implications of this interplay between strain\, bonding and reactivity will be explored through reaction development built upon halogen bonding and photoredox catalysis\,3\,4 offering guidelines to develop reactions that capitalize on strain release reactivity.5  \n[1] Sterling\, A. J.\, Dürr\, A. B.\, Smith\, R. C.\, Anderson\, E. A.\, Duarte\, F.\, Chem. Sci. 2020\, 11\, 4895–4903. \n[2] Sterling\, A. J.\, Smith\, R. C.\, Anderson\, E. A.\, Duarte\, F.\, ChemRxiv 2021 (https://doi.org/10.26434/chemrxiv-2021-n0xm9). \n[3] Livesly\, S.\, Sterling\, A. J.\, Robertson\, C. C.\, Goundry\, W.\, Morris\, J. A.\, Duarte\, F.\, Aïssa\, C.\, Angew. Chem. Int. Ed. 2022\, 61\, e202111291. \n[4] Wong\, M. L. J.\, Sterling\, A. J.\, Mousseau\, J. J.\, Duarte\, F.\, Anderson\, E. A.\, Nat. Commun. 2021\, 12\, 1644. \n[5] Frank\, N.\, Nugent\, J.\, Shire\, B. R.\, Pickford\, H. D.\, Rabe\, P.\, Sterling\, A. J.\, Zarganes-Tzitzikas\, T.\, Grimes\, T.\, Thompson\, A. L.\, Smith\, R. C.\, Schofield\, C. J.\, Brennan\, P. E.\, Duarte\, F.\, Anderson\, E. A.\, Nature 2022\, 611\, 721–726.
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-dr-alistair-sterling/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230117T110000
DTEND;TZID=America/Los_Angeles:20230117T120000
DTSTAMP:20260614T080436
CREATED:20221215T215959Z
LAST-MODIFIED:20230105T211146Z
UID:26926-1673953200-1673956800@www.chemistry.ucla.edu
SUMMARY:Special Biochem Seminar -Jinfan Wang
DESCRIPTION:Title: How does protein synthesis start in eukaryotes?
URL:https://www.chemistry.ucla.edu/events/special-biochem-seminar-jinfan-wang/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230112T160000
DTEND;TZID=America/Los_Angeles:20230112T170000
DTSTAMP:20260614T080436
CREATED:20230107T030847Z
LAST-MODIFIED:20230107T030847Z
UID:27079-1673539200-1673542800@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Dr. Masha Elkin
DESCRIPTION:Abstract: The synthesis of natural products is motivated by their potent biological effects\, enigmatic biosynthetic origins\, and complex molecular structures. Computational tools such as density functional theory and machine learning can provide mechanistic insights and predict reactivity in silico to inform synthetic campaigns. In addition\, computational tools and predictive analytics can guide the development and application of transition-metal catalysis. Several examples of computational approaches to challenges in synthesis and catalysis are presented: selectivity rationalization during the synthesis of berkeleyone A\, machine learning to guide the synthesis of clovane terpenoids\, hybrid modeling to predict the site of late-stage functionalization of pharmaceutical intermediates\, and machine learning to develop new catalysts for olefin hydroformylation. These advances enable more efficient use of synthetic resources and offer modern solutions to pressing challenges in synthesis and catalysis.
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-dr-masha-elkin/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T160000
DTEND;TZID=America/Los_Angeles:20230109T170000
DTSTAMP:20260614T080436
CREATED:20221222T223942Z
LAST-MODIFIED:20230106T003643Z
UID:26977-1673280000-1673283600@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry 228: Dr. Youn Jue (Eunice) Bae
DESCRIPTION:Dr. Bae Flyer
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-228-dr-youn-jue-eunice-bae/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T150000
DTEND;TZID=America/Los_Angeles:20230109T155000
DTSTAMP:20260614T080436
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213346Z
UID:24058-1673276400-1673279400@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Aaron Chavarria
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-01-09/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T110000
DTEND;TZID=America/Los_Angeles:20230109T120000
DTSTAMP:20260614T080436
CREATED:20230105T210547Z
LAST-MODIFIED:20230105T210751Z
UID:27032-1673262000-1673265600@www.chemistry.ucla.edu
SUMMARY:Special Biochemistry Seminar - Michael Lawson
DESCRIPTION:Michael Lawson Seminar \nTitle: Defining the Pathways of Eukaryotic Translational Quality Control \nAbstract: My research examines how protein synthesis concludes on normal and defective mRNAs. Understanding how these processes are choregraphed is crucial for human health; for example\, 11% of all heritable human diseases are caused by premature stop codons. As a postdoctoral fellow\, I defined the molecular events that liberate polypeptides from ribosomes as translation concludes on normal mRNAs. Using an in vitro reconstituted yeast translation system and single-molecule assays\, I tracked the interplay of eukaryotic release factors (eRF1 and eRF3) with ribosomes halted at stop codons. I discovered that eRF1 and eRF3 act together to quickly recognize stop codons and elicit termination via a tightly regulated process that resembles how ribosomes select proper tRNAs in translation elongation\, which explains how translation termination is fast yet also specific for stop codons. Since the release factors are well conserved throughout eukaryotes\, these mechanisms are likely a fundamental feature of eukaryotic protein synthesis. My work also revealed that diverse effectors inhibit translation termination to promote stop codon readthrough\, suggesting a new route to treat diseases caused by premature stop codons which includes cystic fibrosis and hereditary cancers. In the future\, I will use single-molecule and structural approaches to watch translation unfold on defective mRNAs to understand the molecular events used to evaluate mRNAs and prevent the repeated synthesis of toxic proteins.
URL:https://www.chemistry.ucla.edu/events/special-biochemistry-seminar-michael-lawson/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Special Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230105T160000
DTEND;TZID=America/Los_Angeles:20230105T170000
DTSTAMP:20260614T080436
CREATED:20221220T160748Z
LAST-MODIFIED:20221220T160748Z
UID:26958-1672934400-1672938000@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Dr. Saki Ichikawa
DESCRIPTION:Dr. Ichikawa Flyer \nTitle: Natural Recognition Motifs for the E3 Ligase Adapter Cereblon \nAbstract: Understanding the biology of drug target proteins is essential to enhance drug discovery efforts and mechanistic studies. The clinical drugs thalidomide and its derivatives\, known as immunomodulatory drugs (IMiDs)\, are recognized by a conserved binding domain on the E3 ligase adapter cereblon (CRBN)\, resulting in lifesaving anti-cancer treatments or horrific teratogenicity. However\, despite the growing use of CRBN in the lab and clinic\, the mechanisms CRBN uses to recognize protein substrates have escaped definition to date. E3 ligase complexes select proteins for degradation by recognizing degrons\, specific amino acid sequences sufficient to promote ubiquitination and degradation when embedded in a protein substrate. We hypothesized that degrons for the thalidomide-binding domain of CRBN could be installed on its substrates via post-translational modifications. Here\, I will discuss our chemical approaches to discovering a degron for the thalidomide-binding domain of CRBN and its implications for the physiological function and therapeutic engagement of CRBN. \nBio: Saki Ichikawa is currently a postdoctoral fellow in the laboratory of Professor Christina M. Woo at Harvard University\, where she investigates natural substrate recognition mechanisms of the E3 ligase adapter cereblon (CRBN). She obtained a BS in Chemistry from the University of Tokyo (2014)\, where she conducted undergraduate research in the laboratory of Professor Eiichi Nakamura. In 2019\, Saki received her Ph.D. in Chemistry from the Massachusetts Institute of Technology (MIT) under the guidance of Professor Stephen L. Buchwald. While at MIT\, she focused on the development of copper-catalyzed asymmetric hydroamination reactions. By integrating chemical biology\, organic chemistry\, and chemical proteomics\, Saki aims to address significant questions in the chemistry and biology of protein modifications.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-dr-saki-ichikawa/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230105T110000
DTEND;TZID=America/Los_Angeles:20230105T120000
DTSTAMP:20260614T080436
CREATED:20230104T224949Z
LAST-MODIFIED:20230104T225033Z
UID:27014-1672916400-1672920000@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: Dr. Victoria Barber
DESCRIPTION:Dr. Barber Flyer 1.5.23
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-dr-victoria-barber/
LOCATION:via Zoom
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230105T110000
DTEND;TZID=America/Los_Angeles:20230105T120000
DTSTAMP:20260614T080436
CREATED:20221215T215443Z
LAST-MODIFIED:20221215T215527Z
UID:26923-1672916400-1672920000@www.chemistry.ucla.edu
SUMMARY:Special Biochem Seminar - Steve Bonilla
DESCRIPTION:Title: Dissecting Dynamic RNA 3D Landscapes by Cryo-EM
URL:https://www.chemistry.ucla.edu/events/special-biochem-seminar-steve-bonilla/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221208T120000
DTEND;TZID=America/Los_Angeles:20221208T130000
DTSTAMP:20260614T080436
CREATED:20221107T182159Z
LAST-MODIFIED:20221107T182159Z
UID:26043-1670500800-1670504400@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Chenxiang Wang
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/events/chem-218-student-exit-seminar-chenxiang-wang/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Chem 218 Student Exit Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221207T160000
DTEND;TZID=America/Los_Angeles:20221207T173000
DTSTAMP:20260614T080436
CREATED:20221027T172545Z
LAST-MODIFIED:20221027T172545Z
UID:25194-1670428800-1670434200@www.chemistry.ucla.edu
SUMMARY:Jeffrey I. Zink Inorganic Chemistry Seminar Series: Mahdi Abu-Omar
DESCRIPTION:Flyer: Prof. Mahdi Abu-Omar Flyer \nMeet the Speaker: 11 a.m.\, YH 3096 \nTitle: Bifunctional catalysis for upcycling of polyethylene to alkylaromatics \nAbstract: The current scale of plastics production (nearing 400 million tons per year) and the accompanying waste disposal problems represent a largely untapped opportunity for chemical upcycling. Tandem catalytic conversion by platinum supported on γ-alumina converts various polyethylene grades in high yields to liquid alkyl aromatics in the absence of added solvent or molecular hydrogen. These molecules can be used as biodegradable detergents. Coupling exothermic hydrogenolysis with endothermic aromatization renders the overall process thermodynamically accessible despite moderate reaction temperature. The UCSB upcycling process demonstrates how waste polyolefins can be a viable feedstock for the generation of useful and value-added molecules.
URL:https://www.chemistry.ucla.edu/seminars/jeffrey-i-zink-inorganic-chemistry-seminar-series-mahdi-abu-omar/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Inorganic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221206T130000
DTEND;TZID=America/Los_Angeles:20221206T140000
DTSTAMP:20260614T080436
CREATED:20221130T002223Z
LAST-MODIFIED:20221130T002316Z
UID:26496-1670331600-1670335200@www.chemistry.ucla.edu
SUMMARY:Special Materials Chemistry Seminar by Prof. Jennifer Dionne
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/special-materials-chemistry-seminar-by-prof-jennifer-dionne/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Seminars,Special Seminars
END:VEVENT
END:VCALENDAR