BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230126T160000
DTEND;TZID=America/Los_Angeles:20230126T170000
DTSTAMP:20260614T105413
CREATED:20221215T195221Z
LAST-MODIFIED:20221215T195221Z
UID:26918-1674748800-1674752400@www.chemistry.ucla.edu
SUMMARY:Distinguished Lecture Series: Daniel G. Nocera
DESCRIPTION:Flyer TBA \nTitle TBA \nAbstract TBA
URL:https://www.chemistry.ucla.edu/events/distinguished-lecture-series-daniel-g-nocera/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Distinguished Lecture Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230125T160000
DTEND;TZID=America/Los_Angeles:20230125T171500
DTSTAMP:20260614T105413
CREATED:20221215T193726Z
LAST-MODIFIED:20230110T224913Z
UID:26910-1674662400-1674666900@www.chemistry.ucla.edu
SUMMARY:Jeffrey I. Zink Inorganic Chemistry Seminar Series: Elena Meirzadeh
DESCRIPTION:Flyer: Dr. Elena Meirzadeh Flyer \nTitle: From small molecules to infinite superatomic sheets \nAbstract: Developing a precise understanding of structure-function relationships in molecular crystals can allow us to generate a wide range of properties from extremely simple building blocks. In the first half of my talk\, I will discuss how crystal engineering and defects affect the macroscopic properties of amino acid crystals. Moreover\, I will describe the molecular-level determination of the structure of defect sites\, which are below the diffraction detection limit\, using pyroelectric measurement coupled with dispersion-corrected density functional theory calculations and molecular dynamics simulations. In the second half of my talk\, I will introduce a new two-dimensional crystalline form of carbon that we recently synthesized –– graphullerene. The constituent fullerene subunits in these crystals are arranged hexagonally in a covalently interconnected molecular sheet that can be mechanically exfoliated and characterized. I will describe how the properties of graphullerene differ from those of graphene and molecular fullerenes.
URL:https://www.chemistry.ucla.edu/seminars/jeffrey-i-zink-inorganic-chemistry-seminar-series-elena-meirzadeh/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Inorganic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230124T160000
DTEND;TZID=America/Los_Angeles:20230124T170000
DTSTAMP:20260614T105413
CREATED:20230107T033525Z
LAST-MODIFIED:20230107T033525Z
UID:27094-1674576000-1674579600@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Dr. Jose Roque
DESCRIPTION:Modern drug discovery has benefited from advancements in chemical reaction development. For example\, C–H functionalization reactions has transformed how synthetic chemists approach the retrosynthetic analysis of bioactive compounds. Despite recent advances\, the development of site-selective reactions remains a grand challenge in metal-catalyzed C–H functionalization. Typical retrosynthetic analysis results in simplified fragments by the removal of functional groups on the periphery of molecules. As a result\, forward syntheses and diversification of molecules have focused on peripheral modifications. Inspired by the concept of scaffold hopping\, the first part of the presentation will detail an approach to access novel chemical space by focusing on making structural edits to the core framework of molecules. The second part of the presentation will center on addressing site-selectivity and the need for more active first-row transition metal catalysts\, as the low activity and limited scope of known first-row transition metal catalysts severely limit their utility. Cobalt precatalysts supported by pyridine dicarbene pincers have been developed to selectively functionalize electronically distinct C–H bonds without relying on directing groups contrasting traditional approaches. For example\, the meta-selective C(sp2)–H borylation of fluoroarenes\, a significant challenge due to the weak coordinating ability and the similar size of fluorine and hydrogen\, has been demonstrated. Mechanistic studies on fluoroarene borylation established a kinetic preference for C–H bond activation at the meta position\, while cobalt-aryl complexes resulting from ortho C–H activation are thermodynamically preferred. As a result of these mechanistic insights\, the selectivity of a C–H borylation can be switched with a single catalyst by simply modifying the reaction conditions.
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-dr-jose-roque/
LOCATION:Young Hall 2033
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230124T130000
DTEND;TZID=America/Los_Angeles:20230124T143000
DTSTAMP:20260614T105413
CREATED:20221220T220043Z
LAST-MODIFIED:20221220T222155Z
UID:26961-1674565200-1674570600@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series: Parisa Mehrkhodavandi
DESCRIPTION:Title: Cationic indium in catalysis: Generation of functionalized copolymers from commodity monomers \nAbstract: Cationic indium complexes are rare in the field of catalysis. We have developed families of cationic indium complexes supported by tridentate and tetradentate aminophenolate ligands which show reactivity towards cyclic esters\, cyclic ethers\, and copolymerizations with CO 2. We show that\, depending on ligand design\, these complexes are excellent catalysts for the coupling of functionalized epoxides and cyclic esters to form orthoesters\, for the controlled ring opening polymerization of cyclic ethers\, and for the copolymerization of cyclic ethers and esters. Structure-function relationships and mechanistic considerations in each of these systems will be explored.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-for-integrated-catalysis-webinar-series-parisa-mehrkhodavandi/
CATEGORIES:Other,Seminars
LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230123T160000
DTEND;TZID=America/Los_Angeles:20230123T170000
DTSTAMP:20260614T105413
CREATED:20221222T224113Z
LAST-MODIFIED:20230110T221720Z
UID:26979-1674489600-1674493200@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry 228: Dr.  Milena Jovanovic
DESCRIPTION:Dr. Jovanovic Flyer \nTitle: “Delocalized Bonding in Extended Systems: From Molecules to Quantum Materials” \nAbstract: A long list of words attached to extensions of two-center two-electron bonding\, such as\nconjugation\, aromaticity\, electron-deficient\, and electron-rich bonding\, testifies to the ubiquity of\nelectron delocalization and its importance in chemistry. Delocalization certainly has consequences – in\nspectroscopic\, ionization\, and magnetic questions the most prominently – both for discrete molecules\nand for polymers and extended solids. Moreover\, a complex relationship between delocalized bonding\nand quantum properties of extended solids has come to light in recent years. Understanding\ndelocalization mechanisms and how they interact with each other is crucial to designing new quantum\nmaterials.\nMy talk focuses on two cases of electron delocalization in materials: σ delocalization in\npermethylated polysilane and chemical bonding in kagome lattices. In the case of permethylated\npolysilane\, I will explain how strong conformational dependence of the polymer’s properties arises from\nan interplay of two delocalization mechanisms. In the case of compounds featuring the kagome lattice\, I\nwill derive chemical rules to predict if bonding within the lattice is possible and its relation to materials’\nproperties. Additionally\, I will briefly reflect on the other aspects of electron delocalization\, namely non-\ntrivial election localization in crystals and its consequences.
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-228-dr-milena-jovanovic/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230123T150000
DTEND;TZID=America/Los_Angeles:20230123T155000
DTSTAMP:20260614T105413
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213523Z
UID:24060-1674486000-1674489000@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Madeline Ruos
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-01-23/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230120T153000
DTEND;TZID=America/Los_Angeles:20230120T163000
DTSTAMP:20260614T105413
CREATED:20221222T002730Z
LAST-MODIFIED:20221222T002730Z
UID:26972-1674228600-1674232200@www.chemistry.ucla.edu
SUMMARY:Dickerson Biochemistry Seminar Series: Prof. Sarah Keane
DESCRIPTION:Flyer: Sarah Keane Flyer \nTitle: Structure of pre-miR-31 reveals an active role in Dicer processing \nAbstract: As an essential post-transcriptional regulator of gene expression\, microRNA (miR) levels must be strictly maintained. The biogenesis of many\, but not all\, miRs is mediated by trans-acting protein partners through a variety of mechanisms\, including remodeling of the RNA structure. The intrinsic structural properties of RNAs can provide an additional layer of regulation. miR-31 functions as an oncogene in numerous cancers and interestingly\, its biogenesis is not known to be regulated by protein binding partners. We determined the solution structure of the precursor element of miR-31 (pre-miR-31) to investigate the role of distinct structural elements in regulating Dicer processing. We found that the presence or absence of mismatches within the helical stem do not strongly influence Dicer processing of the pre-miR. However\, both the apical loop size and structure at the Dicing site are key elements for discrimination by Dicer. Interestingly\, our NMR-derived structure reveals the presence of a triplet of base pairs that link the Dicer cleavage site and the apical loop. Mutational analysis in this region suggests that the stability of the junction region strongly influence both Dicer binding and processing. Our results enrich our understanding of the active role that RNA structure plays in regulating Dicer processing.
URL:https://www.chemistry.ucla.edu/seminars/dickerson-biochemistry-seminar-series-prof-sarah-keane/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230120T153000
DTEND;TZID=America/Los_Angeles:20230120T163000
DTSTAMP:20260614T105413
CREATED:20221214T003509Z
LAST-MODIFIED:20221214T003509Z
UID:26848-1674228600-1674232200@www.chemistry.ucla.edu
SUMMARY:Biochemistry Seminar Series - Prof. Sarah Keane
DESCRIPTION:Title: TBD \nAbstract: TBD
URL:https://www.chemistry.ucla.edu/seminars/biochemistry-seminar-series-prof-sarah-keane/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230119T160000
DTEND;TZID=America/Los_Angeles:20230119T170000
DTSTAMP:20260614T105413
CREATED:20221201T183346Z
LAST-MODIFIED:20221201T183346Z
UID:26546-1674144000-1674147600@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Tehshik Yoon
DESCRIPTION:Prof. Yoon Flyer \nStereocontrol in Photochemical Synthesis \nAbstract: Photochemistry is intriguing as a synthetic tool because the absorption of light by an organic molecule results in the formation of exceptionally energetic reactive intermediates that can react in ways that are inaccessible to ground-state molecules. However\, this high reactivity is also a challenge for stereoselective synthesis: control over the stereochemistry of photochemical reactions\, particularly using enantioselective catalysts\, has been a long-standing challenging synthetic problem with few general solutions. We recently developed a strategy that utilizes privileged chiral Brønsted acid scaffolds to control both the absolute and relative stereochemistry of complex [2+2] photocycloadditions. These reactions have enabled a general\, concise\, and stereocontrolled  strategy for the synthesis of the truxinate and truxillate natural products.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-tehshik-yoon/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230119T110000
DTEND;TZID=America/Los_Angeles:20230119T120000
DTSTAMP:20260614T105413
CREATED:20221215T220211Z
LAST-MODIFIED:20221215T220211Z
UID:26928-1674126000-1674129600@www.chemistry.ucla.edu
SUMMARY:Special Biochem Seminar - Alex Guseman
DESCRIPTION:Title: Targeting Spike Glycans to Inhibit Viral Entry
URL:https://www.chemistry.ucla.edu/events/special-biochem-seminar-alex-guseman/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230117T160000
DTEND;TZID=America/Los_Angeles:20230117T170000
DTSTAMP:20260614T105413
CREATED:20230107T032733Z
LAST-MODIFIED:20230107T032733Z
UID:27088-1673971200-1673974800@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Dr. Alistair Sterling
DESCRIPTION:Strain is a foundational concept in organic chemistry. Its presence can transform an inert molecule into one with exciting properties\, or steer a reaction toward a single product with exquisite control. Understanding—and importantly\, predicting—the delicate balance between strain and reactivity will enable the full potential of strain to be harnessed for drug discovery\, materials chemistry\, bioconjugation and beyond. In this talk\, efforts to uncover the fundamental principles that govern strain release chemistry will be discussed\, using the highly-strained hydrocarbon [1.1.1]propellane to develop the concept of bond delocalization\,1 before demonstrating how this idea can be generalized to predict the behaviour of all small-ring carbocycles.2 The implications of this interplay between strain\, bonding and reactivity will be explored through reaction development built upon halogen bonding and photoredox catalysis\,3\,4 offering guidelines to develop reactions that capitalize on strain release reactivity.5  \n[1] Sterling\, A. J.\, Dürr\, A. B.\, Smith\, R. C.\, Anderson\, E. A.\, Duarte\, F.\, Chem. Sci. 2020\, 11\, 4895–4903. \n[2] Sterling\, A. J.\, Smith\, R. C.\, Anderson\, E. A.\, Duarte\, F.\, ChemRxiv 2021 (https://doi.org/10.26434/chemrxiv-2021-n0xm9). \n[3] Livesly\, S.\, Sterling\, A. J.\, Robertson\, C. C.\, Goundry\, W.\, Morris\, J. A.\, Duarte\, F.\, Aïssa\, C.\, Angew. Chem. Int. Ed. 2022\, 61\, e202111291. \n[4] Wong\, M. L. J.\, Sterling\, A. J.\, Mousseau\, J. J.\, Duarte\, F.\, Anderson\, E. A.\, Nat. Commun. 2021\, 12\, 1644. \n[5] Frank\, N.\, Nugent\, J.\, Shire\, B. R.\, Pickford\, H. D.\, Rabe\, P.\, Sterling\, A. J.\, Zarganes-Tzitzikas\, T.\, Grimes\, T.\, Thompson\, A. L.\, Smith\, R. C.\, Schofield\, C. J.\, Brennan\, P. E.\, Duarte\, F.\, Anderson\, E. A.\, Nature 2022\, 611\, 721–726.
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-dr-alistair-sterling/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230117T110000
DTEND;TZID=America/Los_Angeles:20230117T120000
DTSTAMP:20260614T105413
CREATED:20221215T215959Z
LAST-MODIFIED:20230105T211146Z
UID:26926-1673953200-1673956800@www.chemistry.ucla.edu
SUMMARY:Special Biochem Seminar -Jinfan Wang
DESCRIPTION:Title: How does protein synthesis start in eukaryotes?
URL:https://www.chemistry.ucla.edu/events/special-biochem-seminar-jinfan-wang/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230112T160000
DTEND;TZID=America/Los_Angeles:20230112T170000
DTSTAMP:20260614T105413
CREATED:20230107T030847Z
LAST-MODIFIED:20230107T030847Z
UID:27079-1673539200-1673542800@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Dr. Masha Elkin
DESCRIPTION:Abstract: The synthesis of natural products is motivated by their potent biological effects\, enigmatic biosynthetic origins\, and complex molecular structures. Computational tools such as density functional theory and machine learning can provide mechanistic insights and predict reactivity in silico to inform synthetic campaigns. In addition\, computational tools and predictive analytics can guide the development and application of transition-metal catalysis. Several examples of computational approaches to challenges in synthesis and catalysis are presented: selectivity rationalization during the synthesis of berkeleyone A\, machine learning to guide the synthesis of clovane terpenoids\, hybrid modeling to predict the site of late-stage functionalization of pharmaceutical intermediates\, and machine learning to develop new catalysts for olefin hydroformylation. These advances enable more efficient use of synthetic resources and offer modern solutions to pressing challenges in synthesis and catalysis.
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-dr-masha-elkin/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T160000
DTEND;TZID=America/Los_Angeles:20230109T170000
DTSTAMP:20260614T105413
CREATED:20221222T223942Z
LAST-MODIFIED:20230106T003643Z
UID:26977-1673280000-1673283600@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry 228: Dr. Youn Jue (Eunice) Bae
DESCRIPTION:Dr. Bae Flyer
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-228-dr-youn-jue-eunice-bae/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T150000
DTEND;TZID=America/Los_Angeles:20230109T155000
DTSTAMP:20260614T105413
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213346Z
UID:24058-1673276400-1673279400@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Aaron Chavarria
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-01-09/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T110000
DTEND;TZID=America/Los_Angeles:20230109T120000
DTSTAMP:20260614T105413
CREATED:20230105T210547Z
LAST-MODIFIED:20230105T210751Z
UID:27032-1673262000-1673265600@www.chemistry.ucla.edu
SUMMARY:Special Biochemistry Seminar - Michael Lawson
DESCRIPTION:Michael Lawson Seminar \nTitle: Defining the Pathways of Eukaryotic Translational Quality Control \nAbstract: My research examines how protein synthesis concludes on normal and defective mRNAs. Understanding how these processes are choregraphed is crucial for human health; for example\, 11% of all heritable human diseases are caused by premature stop codons. As a postdoctoral fellow\, I defined the molecular events that liberate polypeptides from ribosomes as translation concludes on normal mRNAs. Using an in vitro reconstituted yeast translation system and single-molecule assays\, I tracked the interplay of eukaryotic release factors (eRF1 and eRF3) with ribosomes halted at stop codons. I discovered that eRF1 and eRF3 act together to quickly recognize stop codons and elicit termination via a tightly regulated process that resembles how ribosomes select proper tRNAs in translation elongation\, which explains how translation termination is fast yet also specific for stop codons. Since the release factors are well conserved throughout eukaryotes\, these mechanisms are likely a fundamental feature of eukaryotic protein synthesis. My work also revealed that diverse effectors inhibit translation termination to promote stop codon readthrough\, suggesting a new route to treat diseases caused by premature stop codons which includes cystic fibrosis and hereditary cancers. In the future\, I will use single-molecule and structural approaches to watch translation unfold on defective mRNAs to understand the molecular events used to evaluate mRNAs and prevent the repeated synthesis of toxic proteins.
URL:https://www.chemistry.ucla.edu/events/special-biochemistry-seminar-michael-lawson/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Special Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230105T160000
DTEND;TZID=America/Los_Angeles:20230105T170000
DTSTAMP:20260614T105413
CREATED:20221220T160748Z
LAST-MODIFIED:20221220T160748Z
UID:26958-1672934400-1672938000@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Dr. Saki Ichikawa
DESCRIPTION:Dr. Ichikawa Flyer \nTitle: Natural Recognition Motifs for the E3 Ligase Adapter Cereblon \nAbstract: Understanding the biology of drug target proteins is essential to enhance drug discovery efforts and mechanistic studies. The clinical drugs thalidomide and its derivatives\, known as immunomodulatory drugs (IMiDs)\, are recognized by a conserved binding domain on the E3 ligase adapter cereblon (CRBN)\, resulting in lifesaving anti-cancer treatments or horrific teratogenicity. However\, despite the growing use of CRBN in the lab and clinic\, the mechanisms CRBN uses to recognize protein substrates have escaped definition to date. E3 ligase complexes select proteins for degradation by recognizing degrons\, specific amino acid sequences sufficient to promote ubiquitination and degradation when embedded in a protein substrate. We hypothesized that degrons for the thalidomide-binding domain of CRBN could be installed on its substrates via post-translational modifications. Here\, I will discuss our chemical approaches to discovering a degron for the thalidomide-binding domain of CRBN and its implications for the physiological function and therapeutic engagement of CRBN. \nBio: Saki Ichikawa is currently a postdoctoral fellow in the laboratory of Professor Christina M. Woo at Harvard University\, where she investigates natural substrate recognition mechanisms of the E3 ligase adapter cereblon (CRBN). She obtained a BS in Chemistry from the University of Tokyo (2014)\, where she conducted undergraduate research in the laboratory of Professor Eiichi Nakamura. In 2019\, Saki received her Ph.D. in Chemistry from the Massachusetts Institute of Technology (MIT) under the guidance of Professor Stephen L. Buchwald. While at MIT\, she focused on the development of copper-catalyzed asymmetric hydroamination reactions. By integrating chemical biology\, organic chemistry\, and chemical proteomics\, Saki aims to address significant questions in the chemistry and biology of protein modifications.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-dr-saki-ichikawa/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230105T110000
DTEND;TZID=America/Los_Angeles:20230105T120000
DTSTAMP:20260614T105413
CREATED:20230104T224949Z
LAST-MODIFIED:20230104T225033Z
UID:27014-1672916400-1672920000@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: Dr. Victoria Barber
DESCRIPTION:Dr. Barber Flyer 1.5.23
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-dr-victoria-barber/
LOCATION:via Zoom
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230105T110000
DTEND;TZID=America/Los_Angeles:20230105T120000
DTSTAMP:20260614T105413
CREATED:20221215T215443Z
LAST-MODIFIED:20221215T215527Z
UID:26923-1672916400-1672920000@www.chemistry.ucla.edu
SUMMARY:Special Biochem Seminar - Steve Bonilla
DESCRIPTION:Title: Dissecting Dynamic RNA 3D Landscapes by Cryo-EM
URL:https://www.chemistry.ucla.edu/events/special-biochem-seminar-steve-bonilla/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221208T120000
DTEND;TZID=America/Los_Angeles:20221208T130000
DTSTAMP:20260614T105413
CREATED:20221107T182159Z
LAST-MODIFIED:20221107T182159Z
UID:26043-1670500800-1670504400@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Chenxiang Wang
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/events/chem-218-student-exit-seminar-chenxiang-wang/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Chem 218 Student Exit Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221207T160000
DTEND;TZID=America/Los_Angeles:20221207T173000
DTSTAMP:20260614T105413
CREATED:20221027T172545Z
LAST-MODIFIED:20221027T172545Z
UID:25194-1670428800-1670434200@www.chemistry.ucla.edu
SUMMARY:Jeffrey I. Zink Inorganic Chemistry Seminar Series: Mahdi Abu-Omar
DESCRIPTION:Flyer: Prof. Mahdi Abu-Omar Flyer \nMeet the Speaker: 11 a.m.\, YH 3096 \nTitle: Bifunctional catalysis for upcycling of polyethylene to alkylaromatics \nAbstract: The current scale of plastics production (nearing 400 million tons per year) and the accompanying waste disposal problems represent a largely untapped opportunity for chemical upcycling. Tandem catalytic conversion by platinum supported on γ-alumina converts various polyethylene grades in high yields to liquid alkyl aromatics in the absence of added solvent or molecular hydrogen. These molecules can be used as biodegradable detergents. Coupling exothermic hydrogenolysis with endothermic aromatization renders the overall process thermodynamically accessible despite moderate reaction temperature. The UCSB upcycling process demonstrates how waste polyolefins can be a viable feedstock for the generation of useful and value-added molecules.
URL:https://www.chemistry.ucla.edu/seminars/jeffrey-i-zink-inorganic-chemistry-seminar-series-mahdi-abu-omar/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Inorganic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221206T130000
DTEND;TZID=America/Los_Angeles:20221206T140000
DTSTAMP:20260614T105413
CREATED:20221130T002223Z
LAST-MODIFIED:20221130T002316Z
UID:26496-1670331600-1670335200@www.chemistry.ucla.edu
SUMMARY:Special Materials Chemistry Seminar by Prof. Jennifer Dionne
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/special-materials-chemistry-seminar-by-prof-jennifer-dionne/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Seminars,Special Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221201T160000
DTEND;TZID=America/Los_Angeles:20221201T173000
DTSTAMP:20260614T105413
CREATED:20221117T170552Z
LAST-MODIFIED:20221122T015649Z
UID:26218-1669910400-1669915800@www.chemistry.ucla.edu
SUMMARY:Inaugural Dickerson Lecture Biochemistry Seminar Series: Robert M. Stroud
DESCRIPTION:Flyer: Dickerson Lecture Flyer – Robert M. Stroud \nTitle: “Caught in the Act! – Building the Wall!” \nAbstract: From the atomic structure of the first protein\, Myoglobin in which Richard Dickerson played the key role(1)\, proteins were necessarily purified from large animals. Now complex machines can be ‘tagged’ and purified endogenously from cells growing under normal conditions(2)\, revealing their endogenous partnerships\, natural substrates\, and reactions as if trapped ‘in action’. The mycolic acid layer of the Mycobacterium tuberculosis cell wall is essential for viability and virulence\, and the enzymes responsible for its synthesis are therefore targets for antimycobacterial drug development. Polyketide synthase 13 (Pks13) performs the key essential final condensation of mycolic acids. Structures determined by cryogenic electron microscopy of dimeric multi-enzyme Pks13 purified from mycobacteria\, are captured with native endogenous long-chain fatty acid substrates. Structures define the ketosynthase (KS)\, linker domains\, and acyltransferase (AT) domains at 1.8 Å resolution\, and show two alternate locations of the N-terminal acyl carrier protein that delivers substrate from a fatty acid synthase to the KS domain. Other domains\, visible only at low resolution\, are flexible relative to the KS-AT core. These structures\, together with cross linking and integrative modeling suggest intermediate states on the pathway to mycolic acid synthesis(3).
URL:https://www.chemistry.ucla.edu/events/inaugural-dickerson-lecture-biochemistry-seminar-series/
LOCATION:Boyer 159\, 611 Charles E Young Dr E\, Los Angeles\, CA 90095\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221201T160000
DTEND;TZID=America/Los_Angeles:20221201T170000
DTSTAMP:20260614T105413
CREATED:20220902T214825Z
LAST-MODIFIED:20221019T232951Z
UID:23358-1669910400-1669914000@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Sidney Wilkerson-Hill
DESCRIPTION:Seminar Sponsored by Organization for Cultural Diversity in Science \nProf Wilkerson Hill Flyer \nTitle: Orphaned Cyclopropanes \nAbstract: Cyclopropanes are strained carbocycles that have fascinated chemists for decades with many established methods for their construction. Unfortunately\, many methods struggle to build cyclopropanes containing only alkyl functionality\, which limits access to antiviral medicines (e.g.\, nirmatrelvir)\, pyrethroid insecticides and sesquiterpenoid natural products. These cyclopropanes have been “orphaned” or left behind by state-of-the-art cycloaddition methods and are typically characterized as arising from the transfer of a unstabilized carbene unit. The goals of the Hill group are to develop new methods to obtain orphaned cyclopropanes and to use these strategies to address the coming “insectocalypse”. To this end\, we have developed three cyclopropanation methods that break with traditional paradigms and enable the rational design and facile access to orphaned cyclopropanes. Our most recent approach leverages the high reactivity of lithiosulfones to transfer dialkyl carbene groups to styrenes.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-sidney-wilkerson-hill/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221201T120000
DTEND;TZID=America/Los_Angeles:20221201T130000
DTSTAMP:20260614T105413
CREATED:20221107T181840Z
LAST-MODIFIED:20221107T181840Z
UID:26041-1669896000-1669899600@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Mengzhen Chen
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/events/chem-218-student-exit-seminar-mengzhen-chen/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Chem 218 Student Exit Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221130T160000
DTEND;TZID=America/Los_Angeles:20221130T173000
DTSTAMP:20260614T105413
CREATED:20221027T172328Z
LAST-MODIFIED:20221129T175724Z
UID:25189-1669824000-1669829400@www.chemistry.ucla.edu
SUMMARY:Jeffrey I. Zink Inorganic Chemistry Seminar Series: Megan Fieser
DESCRIPTION:Flyer: Prof. Megan Fieser Flyer \nMeet the Speaker: 11 a.m.\, YH 3096 \nTitle: Development of Catalytic Strategies for Advances in Polymer Sustainability \nAbstract: As we strive to support our busy and demanding lifestyles\, our dependence on disposable plastics has led to a global environmental crisis. The high stability of plastics to an array of conditions that was once highlighted as a value for commercialization has now become a serious flaw. Addressing this crisis is going to require collective efforts to recycle or upcycle the commercial products already produced at large scale and to develop more degradable or recyclable replacements. The Fieser group strives to achieve these ends through two research thrusts. In our polymerization thrust\, rare earth metal catalysts are being developed for the synthesis of degradable plastics through the perfectly alternating copolymerization of epoxides and cyclic anhydrides and the block copolymerization of 1\,3-dienes with cyclic esters. Using a host of complementary techniques\, we demonstrate the development of efficient synthetic methods\, thorough characterization of physical properties of the resulting polymers\, and proof-of-concepts for future recycling processes. In our depolymerization thrust\, we are exploring environmentally-friendly catalytic methods for the dechlorination of polyvinyl chloride\, with an emphasis on establishing control over product selectivity. Using both inorganic and organic catalyst systems\, we show facile tunability of the organic polymer product for potential assimilation to varying applications. Recent advances from both research thrusts will be discussed.
URL:https://www.chemistry.ucla.edu/seminars/jeffrey-i-zink-inorganic-chemistry-seminar-series-megan-fieser/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Inorganic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221128T150000
DTEND;TZID=America/Los_Angeles:20221128T155000
DTSTAMP:20260614T105413
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T212707Z
UID:24052-1669647600-1669650600@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Gabriella Cooper
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2022-11-28/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221121T160000
DTEND;TZID=America/Los_Angeles:20221121T170000
DTSTAMP:20260614T105413
CREATED:20220902T204706Z
LAST-MODIFIED:20221023T215142Z
UID:23325-1669046400-1669050000@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: Vojtech Vleck
DESCRIPTION:Prof. Vlcek Flyer \nTitle: Excitation Dynamics Driving the Electronic Structure of Molecules and Solids \nAbstract: Capturing the dynamics of electronic excitations in realistic systems containing more than a few electrons is one of the outstanding theoretical challenges. Dynamical quantum correlations mediate interactions and couplings between multiple excited states in materials and represent an important driver of their optoelectronic characteristics. A predictive ab-initio theory is thus critical for understanding\, predicting\, and designing novel compounds with tailored (quantum) properties. I will discuss how to tackle the first-principles description of excitation dynamics in systems with thousands of electrons and study individual excited states\, including their non-trivial interactions. I will exemplify these approaches in practical applications to quantum materials\, e.g.\, exploring the correlated phenomena for localized moire states in twisted bilayer graphene and defect centers in diamond. Our theoretical framework uses real-time methods combined with ab-initio dynamical downfolding. Together with efficient low-scaling numerical techniques\, it is generally applicable to (quantum) material science and chemistry problems and constitutes an ideal platform for simulating complex nanoscale systems\, such as molecular assemblies or materials interfaces.
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-vojtech-vleck/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221121T150000
DTEND;TZID=America/Los_Angeles:20221121T155000
DTSTAMP:20260614T105413
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T212506Z
UID:24051-1669042800-1669045800@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Emma Greene
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2022-11-21/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221117T160000
DTEND;TZID=America/Los_Angeles:20221117T170000
DTSTAMP:20260614T105413
CREATED:20220902T214234Z
LAST-MODIFIED:20221116T172931Z
UID:23355-1668700800-1668704400@www.chemistry.ucla.edu
SUMMARY:CANCELED: Houk-Jung Organic Colloquium 247: Elizabeth Gilles
DESCRIPTION:PLEASE NOTE THAT THIS EVENT HAS BEEN CANCELED \n  \n  \nProf. Gilles Flyer \nTitle: Self-Immolative Polymers: Chemical Designs and Applications \nAbstract: The development of degradable polymers is of significant interest across a wide range of fields from commodity plastics to medicine. Much progress has been made to date with conventional polyesters such as polylactide and polycaprolactone. However\, the ability to control the degradation of these polymers in different environments is limited and they may degrade more rapidly or more slowly than desired. Many stimuli-responsive polymers have been developed over the past couple of decades\, but these polymers typically require many stimuli-mediated events to achieve complete backbone degradation. Our team has been developing self-immolative polymers\, a recently established class of degradable polymers\, that undergo end-to-end backbone depolymerization in response to the cleavage of a single backbone bond or an end-cap from the polymer terminus\, thereby providing amplification of the stimulus-mediated event. This presentation will describe the development of different classes of self-immolative polymers\, as well as end-caps for these polymers\, which can be triggered under different conditions. Our progress in the synthesis of these polymers\, as well as their application in areas such as therapeutic delivery and medical imaging will be discussed.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-elizabeth-gilles/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
END:VCALENDAR