UCLA

Organic Colloquium - Prof. Andrew McNally
2022-04-21 16:00 (America/Los_Angeles)
Selective Functionalization of Pyridines, Diazines and Pharmaceuticals via Unconventional Intermediates

Chem 218 Student Exit Seminar - Chris Dunham
2022-04-21 12:00

Chem 278: Prof. Adam S. Veige
2022-04-20 16:00
TBA

Chem 263/Chemical Biology Seminar-Prof. Pamela Chang
2022-04-19 16:00
Questions? Please contact Isabella Diaz at maynardadmin@chem.ucla.edu

Chem 228: Prof. Shu-ou Shan
2022-04-18 16:00
“Nascent Protein Selection and Triage at the Ribosome”

Chem 268 (Midstream Presentation) - Andrew Goring and Ashley Julio
2022-04-15 15:30

No Seminar
2022-04-14 16:00, 2022-04-07 16:00

Chem 278: Prof. Alina M. Schimpf
2022-04-13 16:00
“Solution-phase routes to inorganic solid-state materials”

Chem 263/Chemical Biology Seminar-Professor Jeremy Baskin
2022-04-12 16:00

NSF Center for Integrated Catalysis Webinar Series
2022-04-12 12:30
Stereoconvergent and Stereodivergent Synthesis with Configurationally Unstable Compounds

Chem 268 (Midstream Presentation) - Noelle Novales and Sean Atamdede
2022-04-08 15:30

Chem 278: Prof. Robert J. Gilliard
2022-04-06 16:00
“Beryllium, Boron, and Bismuth: From Fundamental Redox Chemistry to Luminescent Materials”

Chem 263 Student Exit Seminar- Christopher Sue
2022-04-05 16:00

Chem 228: Prof. Dan Neumark
2022-04-04 16:00
“Attosecond Science and its Applications to Atomic, Molecular, and Chemical Physics”

Chem 268 (Midstream Presentation) - Alexander Stevens
2022-04-01 15:30

Organic Colloquium - Prof. Vincent N. G. Lindsay
2022-03-31 16:00
Stereoselective Synthesis and Applications of Sulfonylcyclopropanols as Modular Cyclopropanone and Homoenolate Equivalents

Chem 218 Student Exit Seminar: Gail Vinnacombe
2022-03-31 12:00
“Surface Functionalization, Patterning, and in Situ Growth of Gold Nanoparticles”

The 2022 Cabot Microelectronics Corp. Lecture
2022-03-30 16:00
A new era in solar energy conversion and optoelectronics enabled by the humble halide perovskites?

Chem 278: Prof. Karsten Meyer
2022-03-29 16:00
“Super-Oxidized” Iron Nitrido/Imido and “Super-Reduced” Iron Nitrosyl Complexes in tris-Carbene Coordination Spheres – and how Iron Really Feels About it

Chem 228: Prof. Thuc-Quyen Nguyen
2022-03-28 16:00
“Understanding Unconventional Doping Mechanisms in Organic Semiconductors”

Special Organic Colloquium - Prof. Joshua G. Pierce
2022-03-24 16:00
Complex Molecule Synthesis at the Interface of Biology: Adventures in Medicinal Chemistry and Chemical Biology

Chem 218 Student Exit Seminar: Yiyi Yao
2022-03-17 12:00
“Structural Stability and Phase Transformation Behavior in Nanostructured Energy Storage Materials”

Chem 278: Prof. Kimberly A. See
2022-03-16 16:15
“One is the Loneliest Number: Multivalent and Multielectron Processes for Next-Generation Batteries”

Catalysis Lectureship 2022 - Christophe Copéret, ETH Zürich
2022-03-16 14:30
Bridging the gap between well-defined and industrial catalysts via a molecular approach
Industrial processes, in particular large-scale ones, mostly rely on heterogeneous catalysts. The search for more sustainable processes and the changes in environmental policies impose the continuous development of improved catalyst performances and catalytic processes, as well as the exploration of alternative routes. However, due to their inherent complexity, heterogeneous catalysts are mostly developed empirically rather than through detailed structure – activity relationships as the nature of the active sites are rarely known.
In this context, our group has been interested in understanding and controlling chemistry on surfaces, with the ultimate goal to generate isolated metal sites with defined chemical environment.[1] This approach has been used to develop highly active and selective single-site catalysts that can overperformed their homogeneous counterparts, but it can also provide useful information to understand and further develop industrial catalysts[2] or to study much more complex systems such as supported nanoparticles, where support effects, interfaces, alloying… remain complex to understand at the molecular level.
This lecture will be developed around these themes and will show that a careful characterization of surface sites on a molecular level is key to develop high performance catalysts and to bridge the gap between fundamental and applied catalysis.[3]
References:
1 C. Copéret, A. Comas-Vives, M. P. Conley, D. Estes, A. Fedorov, V. Mougel, H. Nagae, F. Núñez-Zarur, P. A. Zhizhko Surface Organometallic and Coordination Chemistry towards Single-Site Heterogeneous Catalysts: Strategies, Methods, Structures, and Activities. Chem. Rev. 2016, 16, 323-421. DOI: 10.1021/acs.chemrev.5b00373
2 C. Copéret, F. Allouche, K. W. Chan, M. P. Conley, M. F. Delley, A. Fedorov, I. B. Moroz, V. Mougel, M. Pucino, K. Searles, K. Yamamoto, P. A. Zhizhko, Bridging the Gap between Industrial and Well-Defined Supported Catalysts. Angew. Chem. Int. Ed. 2018, 57, 6398-6440. DOI: 10.1002/anie.201702387
3 a) C. Copéret Single-Sites and Nanoparticles at Tailored Interfaces Prepared via Surface Organometallic Chemistry from Thermolytic Molecular Precursors. Acc. Chem. Res. 2019, 52, 1697-1708. DOI: 10.1021/acs.accounts.9b001388. b) Deciphering Metal-Oxide and Metal-Metal Interplay via Surface Organometallic Chemistry: A Case Study with CO2 Hydrogenation to Methanol. S. R. Docherty, C. Copéret J. Am. Chem. Soc. 2021, 143, 6767–6780. DOI: 10.1021/jacs.1c02555. c) Heterogeneous Alkane Dehydrogenation Catalysts Investigated via a Surface Organometallic Chemistry Approach. S. R. Docherty, L. Rochlitz, P.-A. Payard, C. Copéret Chem. Soc. Rev. 2021, 50, 5806 – 5822. DOI: 10.1039/d0cs01424a.

NSF Center for Integrated Catalysis Webinar Series
2022-03-15 12:30
“Towards understanding the role of mass transport in electrocatalysis: the role of dimensionless analysis and multi-scale modeling”

Chem 268 - John E. (Jack) Johnson
2022-03-11 15:30
“Biophysical Studies of an RNA Virus particle and its Maturation: Insights into an Elegantly Programmed Nano-machine”

Special Organic Colloquium - Prof. Herman O. Sintim
2022-03-10 16:00
Novel chemotypes of kinase inhibitors for the potential treatment of recurrent cancers
Abstract: Therapeutic resistance remains a critical issue in cancer treatment. While cancer patients who harbor dysregulated protein kinases benefit from the use of kinase inhibitors (KIs), many fail therapy and almost all patients become resistant to treatment, indicating a critical unmet need to prevent treatment failure.
Thus far (as of December 2021), the FDA has approved 69 protein kinase inhibitors and several others are also in various stages of clinical trials. Although many compounds that inhibit protein kinases have been described in the literature, only a small region of the chemical space has been explored for protein kinase inhibition and the majority of FDA approved kinase inhibitors contain only a handful of core moieties, such as indazole, quinoline, isoquinoline, quinazoline, pyrazole and pyrimidine. To belabor this point, about ~20% of FDA-approved protein kinases contain the pyrimidine moiety while six drugs contain quinazoline and eight drugs contain pyrazole. In other words, about 50% of approved protein kinase inhibitors contain one of pyrimidine, pyrazole or quinazoline, highlighting the lack of progress in using other regions of the chemical space to drug protein kinases. The Sintim group, integrating computational and experimental workflows, has identified a few novel chemotypes that inhibit disease-associated protein kinases (such as FLT3, RET, CDKs, Haspin) with sub-nanomolar IC50 values. Some of these new KI are long residence time (hours) inhibitors and have shown impressive efficacies in animal models of various cancers. Two of such compounds are currently undergoing toxicology studies to determine safe dosing regimens for potential phase 1 clinical trials against drug-resistant FLT3 (F691L and D835V/Y)-driven AML and RET (solvent front mutations)-driven lung cancers

Chem 218: Student Exit Seminar
2022-03-10 12:00
“Choosing the right lens: Energy surfaces and chemical identity in the photodissociation of Na2+ in different solvent environments”

Chem 278: Prof. James McCusker
2022-03-09 16:00
“Ultrafast Synthesis: Leveraging Time-resolved Spectroscopy for Targeted Synthetic Control of Ultrafast Dynamics in Transition Metal-based Chromophores”
Abstract: The interconversion of light and chemical energy is one of the most fundamental processes on Earth. Research on solar energy conversion, for example – which will ultimately lead to the next generation of solar energy technologies – has sought to replicate Nature’s solution through the realization of artificial constructs that mimic various aspects of photosynthesis. Whether it is the creation of potential gradients to generate current (i.e., photovoltaics) or more recent efforts coupling photo-generated electrons and holes to catalysts (e.g., photoredox catalysis), the critical first step is the absorption of light and the subsequent separation of charge. Transition metal-based chromophores are particularly well-suited for use in such schemes by virtue of the charge-transfer excited-states that a majority of them possess. Indeed, tremendous advances have been made through use of compounds such as [Ru(bpy)3]2+ and Ir(ppy)3 in areas ranging from solar energy conversion to photoredox catalysis. Despite the obvious advantages of ruthenium- and iridium-based chromophores, the fact that these elements are among the rarest in the earth’s crust raises legitimate questions concerning cost and scalability of processes reliant on such chromophores. Such issues, coupled with the possibility of unlocking new chemistry, has motivated exploring the possibility of replacing these compounds with chromophores based on earth-abundant first-row transition metals that can carry out analogous excited-state reaction chemistry. With these opportunities come significant challenges due to inherent differences in the electronic structures of first- versus second- and third-row metal complexes that profoundly impact the ability of such compounds to engage in the desired chemistry. The focus of our research program is therefore to understand the factors that determine the dynamics associated with charge-transfer excited-states of first-row transition metal-based chromophores, with the ultimate goal of circumventing and/or redefining their intrinsic photophysics in order to make feasible their use in a variety of light-driven applications. This seminar will outline the key scientific issues defining this challenge as well as discuss recent examples from our lab illustrating how these challenges can be met and, ultimately, overcome.
