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X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
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TZID:America/Los_Angeles
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TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
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TZOFFSETFROM:-0700
TZOFFSETTO:-0800
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DTSTART:20221106T090000
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220217T120000
DTEND;TZID=America/Los_Angeles:20220217T120000
DTSTAMP:20260615T003357
CREATED:20220121T013351Z
LAST-MODIFIED:20220121T013351Z
UID:13597-1645099200-1645099200@www.chemistry.ucla.edu
SUMMARY:Dr. Joonho Lee. Postdoctoral Fellow\, Columbia University/Google Quantum AI  Seminar
DESCRIPTION:Challenging Problems in Quantum Chemistry: How to Diagnose Them and How to Tackle Them \nQuantum chemistry has become an indispensable tool in revealing the microscopic details of molecules and materials such as barrier heights\, interaction energies\, and correlation functions. The nature of electronic correlation is sometimes controversial\, obscuring the optimal choice of quantum chemistry methods with minimal computational effort and the desired accuracy. First\, I will discuss a computational framework that addresses this question using regularized perturbation theory. Second\, I will also discuss several challenging problems beyond the scope of such perturbation theory. I will argue that these problems can be tackled by methods based on auxiliary-field quantum Monte Carlo. Lastly\, I will present my latest development of a new quantum-classical hybrid algorithm in this context\, which represents the largest quantum computation of chemical systems on a quantum computer to date. 
URL:https://www.chemistry.ucla.edu/seminars/dr-joonho-lee-postdoctoral-fellow-columbia-universitygoogle-quantum-ai-seminar/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220216T160000
DTEND;TZID=America/Los_Angeles:20220216T160000
DTSTAMP:20260615T003357
CREATED:20211215T172337Z
LAST-MODIFIED:20211215T172337Z
UID:13565-1645027200-1645027200@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Thomas Kempa
DESCRIPTION:“Precision Synthesis of Quantum Material Building Blocks”
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-thomas-kempa/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220216T140000
DTEND;TZID=America/Los_Angeles:20220216T140000
DTSTAMP:20260615T003357
CREATED:20211217T214747Z
LAST-MODIFIED:20211217T214747Z
UID:13580-1645020000-1645020000@www.chemistry.ucla.edu
SUMMARY:Special Biochem/PChem Seminar - Eitan Lerner
DESCRIPTION:“Structure-function relationship of an unstructured protein – the alpha-Synuclein case”
URL:https://www.chemistry.ucla.edu/seminars/special-biochempchem-seminar-eitan-lerner/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220216T103000
DTEND;TZID=America/Los_Angeles:20220216T103000
DTSTAMP:20260615T003357
CREATED:20220211T184013Z
LAST-MODIFIED:20220211T184013Z
UID:13605-1645007400-1645007400@www.chemistry.ucla.edu
SUMMARY:Investigating Selectivity in Complex Systems: from Total Synthesis to Glycan Labeling
DESCRIPTION:Abstract: The indole diterpenoids constitute a family of natural products that exhibit potent and selective Big Potassium (BK) ion channel inhibition. We have developed a unified synthetic strategy towards the indole diterpenoid class\, culminating in the total synthesis of several representative congeners\, including paspaline A and emindole PB. Density functional theory calculations are utilized to interrogate a simplifying key bond formation in a predictive capacity to aid in the selection of the most favorable precursor substrate. This work highlights how retrosynthetic design can be augmented with quantum chemical calculations to reveal energetically feasible synthetic disconnections\, minimizing time- consuming and expensive empirical evaluation. Furthermore\, these studies provide modular entry to privileged indole diterpenoid class of natural products\, enabling their application as tool compounds for interrogating BK channel dynamics\, as well as therapeutic leads for channelopathies linked to BK channel dysregulation.   \nGlycans are ubiquitous and play important biological roles\, yet chemical methods for probing their structure and function within cells remain limited. Strategies for studying other biomacromolecules\, such as proteins\, often exploit chemoselective reactions for covalent modification\, capture\, or imaging. Unlike amino acids that constitute proteins\, glycan building blocks lack distinguishing reactivity because they are composed primarily of polyol isomers. Moreover\, encoding glycan variants through genetic manipulation is complex. To address these limitations\, we have developed a new\, generalizable strategy for monomer-selective glycan modification that exploits the reactivity of cellular glycosyltransferases by designing reagents with bioorthogonal handles that function as substrate surrogates. Further\, we demonstrate the utility of these labeling reagents by using them to study the biosynthesis\, localization\, and dynamics of cell wall glycans in mycobacteria. 
URL:https://www.chemistry.ucla.edu/seminars/investigating-selectivity-complex-systems-total-synthesis-glycan-labeling/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220215T160000
DTEND;TZID=America/Los_Angeles:20220215T160000
DTSTAMP:20260615T003357
CREATED:20220211T183814Z
LAST-MODIFIED:20220211T183814Z
UID:13604-1644940800-1644940800@www.chemistry.ucla.edu
SUMMARY:Chemical Strategies for Regulating DNA-Interactive Proteins: Targeting APOBEC Cytosine Deaminases and the N-Myc Transcription Factor
DESCRIPTION:Abstract: Our laboratory focuses on the development of small molecule ligands and enzymatic inhibitors of proteins that interact with nucleic acids. We utilize biophysical and biochemical assays to screen chemical libraries to discover protein-binding ligands\, which are then optimized using iterative rounds of molecular design\, synthesis\, and biological evaluation. Our overarching goals are to develop chemical probes to enable the discovery of new biology by the biomedical research community\, as well as develop novel and patentable therapeutic compounds for clinical development by a pharmaceutical partner. In this vein\, two programs from our laboratory\, the discovery of APOBEC inhibitors and N-Myc degraders\, will be presented. \nAPOBEC enzymes are a family of 7 human DNA cytosine-to-uracil deaminases that degrade foreign DNA as part of the innate immune response to pathogen infection. However\, APOBEC enzymes have been shown to contribute C-to-U/T mutations that enable virus and cancer cell genomic mutations that confer resistance to drug therapies. Consequently\, small molecule APOBEC inhibitors may have utility as “anti-mutation” therapies that slow or prevent the evolution of resistance mutations that defeat targeted drug therapies. Our work to develop first-in-class APOBEC inhibitors will be presented. \nThe Myc family of transcription factors are master regulators of proliferation in the majority of human cancers. In the case of childhood neuroblastomas\, which are the most prevalent cancer in children under 1-year of age\, N-Myc is a validated therapeutic target and molecular diagnostic. A vulnerability of N-Myc in many neuroblastomas is that N-Myc is stabilized from proteolytic degradation by Aurora kinase A (Aurora-A). We have developed novel chemical degraders of Aurora-A\, such as HLB-0532259\, that elicit the degradation of Aurora-A and the concomitant degradation of N-Myc. HLB-0532259 also exhibits potent antiproliferative activity in neuroblastoma cells and xenograft mouse models. Our work to develop novel N-Myc degraders will be presented.
URL:https://www.chemistry.ucla.edu/seminars/chemical-strategies-regulating-dna-interactive-proteins-targeting-apobec-cytosine/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220214T160000
DTEND;TZID=America/Los_Angeles:20220214T160000
DTSTAMP:20260615T003357
CREATED:20211217T214351Z
LAST-MODIFIED:20211217T214351Z
UID:13578-1644854400-1644854400@www.chemistry.ucla.edu
SUMMARY:Chem 228: David Pine
DESCRIPTION:“Self-assembly of colloidal diamond for photonics”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-david-pine/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220211T153000
DTEND;TZID=America/Los_Angeles:20220211T153000
DTSTAMP:20260615T003357
CREATED:20211217T213646Z
LAST-MODIFIED:20211217T213646Z
UID:13577-1644593400-1644593400@www.chemistry.ucla.edu
SUMMARY:Chem 268 - David Moffet
DESCRIPTION:“Untangling Amyloid: Slowing the Progression of Type 2 Diabetes”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-david-moffet/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220210T160000
DTEND;TZID=America/Los_Angeles:20220210T160000
DTSTAMP:20260615T003357
CREATED:20210816T221714Z
LAST-MODIFIED:20210816T221714Z
UID:13533-1644508800-1644508800@www.chemistry.ucla.edu
SUMMARY:Battery-Inspired Strategies for Electrocatalytic C–C and C–N Bond-Forming Reactions
DESCRIPTION:Abstract: The seminar will describe our efforts towards the development of scalable\, mild\, and general electrosynthetic methodologies for C–C and C–N/X coupling reactions. These electrosynthetic methodologies are largely possible because of a synergy between redox-active mediators developed by the energy storage community and transition metal catalysts. It will be shown that yields from electrocatalytic reactions are greatly improved by the incorporation of co-catalytic quantities of soluble battery compounds that mediate electron transfer with the coupling catalyst or protect the coupling catalyst from over-oxidation/reduction and degradation. \nEmploying mediators with properly tuned redox potentials and electron-transfer kinetics\, we demonstrate electrocatalytic cross-electrophile coupling reactions of (hetero) aryl halides and alkyl halides that represent the state of the art in the area. Additionally\, we demonstrate a broad scope for Chan-Lam coupling of amines and arylboronic acids in the absence of a chemical oxidants. Our studies reveal unique mechanisms that are only accessible under electrochemical conditions that enable cross coupling of tertiary electrophiles or arylchlorides: challenging substrates that are currently incompatible with any form of reductive activation.
URL:https://www.chemistry.ucla.edu/seminars/tba-14/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220210T120000
DTEND;TZID=America/Los_Angeles:20220210T120000
DTSTAMP:20260615T003357
CREATED:20220121T010646Z
LAST-MODIFIED:20220121T010646Z
UID:13596-1644494400-1644494400@www.chemistry.ucla.edu
SUMMARY:James Gaynor\, Postdoc Fellow\, University of California\, Berkeley Seminar
DESCRIPTION:Stories of Coherence: From Vibronic to Electronic Phenomena \nA robust understanding of chemical reactivity in excited states is essential for designing and discovering new ways of harnessing energy flow at the atomic and molecular level. Photo-induced coherent processes\, which utilize atomic or molecular motions moving with a well-defined phase relationship\, may enhance control over important photochemical events. This presentation explores a wide range of timescales over which coherence and decoherence occur in solution phase molecules\, gas phase atoms\, and in “atomic-like” excitations of a crystalline ionic solid. We will begin with a new perspective on the first two picoseconds of excited state charge transfer involving coupled electronic and vibrational (i.e.\, “vibronic”) motions in solution phase solar cell dye molecules. Next\, pure electronic coherences in a noble gas are investigated in the absence of vibrational or environmental perturbations\, lasting for hundreds of femtoseconds. Finally\, we return to the condensed phase in the solid form\, where many-body electron correlations appear to cause core-excited state dephasing on sub-10 femtosecond timescales.
URL:https://www.chemistry.ucla.edu/seminars/james-gaynor-postdoc-fellow-university-california-berkeley-seminar/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220209T160000
DTEND;TZID=America/Los_Angeles:20220209T160000
DTSTAMP:20260615T003357
CREATED:20211215T172113Z
LAST-MODIFIED:20211215T172113Z
UID:13564-1644422400-1644422400@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Robert Macfarlane
DESCRIPTION:“Macroscopic Materials from Nanoparticle Assembly”
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-robert-macfarlane/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220209T103000
DTEND;TZID=America/Los_Angeles:20220209T103000
DTSTAMP:20260615T003357
CREATED:20220204T010500Z
LAST-MODIFIED:20220204T010500Z
UID:13603-1644402600-1644402600@www.chemistry.ucla.edu
SUMMARY:Strategic Bond Construction and Cleavage Enabled by Photocatalytic Radical Transformations
DESCRIPTION:Abstract: Radical chemistry is an important class of reactions in modern organic synthesis\, due to the high reactivity and versatile bond formation and cleavage events that can happen with radical intermediates. One of the current challenges in radical chemistry is to generate these reactive open-shell intermediates from accessible starting materials under mild conditions. We have developed several powerful strategies to homolytically cleave strong X–H bonds and generate the corresponding X• radical via proton-coupled electron transfer (PCET). In this talk\, I will present a photocatalytic intermolecular anti-Markovnikov hydroamination reaction of sulfonamides\, and a remote C–H alkylation reaction of amides\, enabled by the amidyl radicals generated via PCET. Moreover\, we also developed a photocatalytic condition to conduct various carbocation reactions via mesolytic cleavage of alkoxyamine compounds. Lastly\, to understand the remarkable chemoselectivity and improve the quantum efficiency of a set of photocatalytic hydroamination reactions\, we performed detailed mechanistic studies\, using advanced spectroscopic and electroanalytical tools to unveil the origin of the chemoselectivity of this reaction\, and also improved the reaction quantum yields. Based on these studies\, gram-scale synthesis of several dialkylamines were performed in a flow reactor.
URL:https://www.chemistry.ucla.edu/seminars/strategic-bond-construction-and-cleavage-enabled-photocatalytic-radical-transformations/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220208T160000
DTEND;TZID=America/Los_Angeles:20220208T160000
DTSTAMP:20260615T003357
CREATED:20220114T184004Z
LAST-MODIFIED:20220114T184004Z
UID:13592-1644336000-1644336000@www.chemistry.ucla.edu
SUMMARY:Chem 278: Special Inorganic Chemistry Seminar - Dr. Benjamin E. R. Snyder
DESCRIPTION:“Iron and Copper Active Sites in Porous Materials and Their Correlation to Metalloenzymes” 
URL:https://www.chemistry.ucla.edu/seminars/chem-278-special-inorganic-chemistry-seminar-dr-benjamin-e-r-snyder/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220208T123000
DTEND;TZID=America/Los_Angeles:20220208T123000
DTSTAMP:20260615T003357
CREATED:20220201T201338Z
LAST-MODIFIED:20220201T201338Z
UID:13602-1644323400-1644323400@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday\, February 8th\, 2022 at 12:30 PM. We are pleased to invite all students\, postdocs\, faculty\, and staff.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-11/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220207T160000
DTEND;TZID=America/Los_Angeles:20220207T160000
DTSTAMP:20260615T003357
CREATED:20211217T212250Z
LAST-MODIFIED:20211217T212250Z
UID:13576-1644249600-1644249600@www.chemistry.ucla.edu
SUMMARY:Chem 228: Michael B. Elowitz
DESCRIPTION:“Multicellular Circuit Design” 
URL:https://www.chemistry.ucla.edu/seminars/chem-228-michael-b-elowitz/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220207T120000
DTEND;TZID=America/Los_Angeles:20220207T120000
DTSTAMP:20260615T003357
CREATED:20220125T234259Z
LAST-MODIFIED:20220125T234259Z
UID:13600-1644235200-1644235200@www.chemistry.ucla.edu
SUMMARY:Dr. Vida Jamali - Postdoctoral Researcher\, Alivisatos lab\, University of California Berkeley
DESCRIPTION:Imaging\, Learning\, and Engineering of Soft Matter Systems at the Nanoscale \nThe motion and dynamics of nanoparticles and macromolecules in bulk and at interfaces is of fundamental importance in physics\, chemistry\, and biology. Liquid phase transmission electron microscopy (LPTEM) is an emerging technique which enables nanoscale visualization of the motion and dynamics of single nanoparticles in liquid environment with an unprecedented spatial and temporal resolution. However\, in order to develop LPTEM as a tool for in situ single nanoparticle and macromolecule tracking\, we first need to understand how the electron beam of a transmission electron microscope affects the particle motion in the liquid environment and near surfaces. \nIn this talk\, I will present my recent work on studying the anomalous diffusive motion of a model system of gold nanorods dispersed in water and moving near the silicon nitride membrane of a commercial liquid cell in a broad range of electron beam dose rates. By leveraging the power of convolutional deep neural networks inspired by canonical statistical tests\, I show that there is a crossover in diffusive behavior of nanoparticles in LPTEM from fractional Brownian motion at low dose rates\, resembling diffusion in a viscoelastic medium\, to continuous time random walk at high dose rates\, resembling diffusion on an energy landscape with trapping sites. I will then discuss how this work forms the foundation to study equilibrium and nonequilibrium dynamic processes for a broad range of nanoparticles\, interfaces\, and fluids in chemical and biological systems.
URL:https://www.chemistry.ucla.edu/seminars/dr-vida-jamali-postdoctoral-researcher-alivisatos-lab-university-california-berkeley/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220204T153000
DTEND;TZID=America/Los_Angeles:20220204T153000
DTSTAMP:20260615T003357
CREATED:20211217T212026Z
LAST-MODIFIED:20211217T212026Z
UID:13575-1643988600-1643988600@www.chemistry.ucla.edu
SUMMARY:Chem 268 - Nicholas Graham
DESCRIPTION:“Identifying and decoding the function of the post-translational modifications arginine methylation and phosphorylation with proteomics”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-nicholas-graham/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220203T160000
DTEND;TZID=America/Los_Angeles:20220203T160000
DTSTAMP:20260615T003357
CREATED:20210816T221633Z
LAST-MODIFIED:20210816T221633Z
UID:13532-1643904000-1643904000@www.chemistry.ucla.edu
SUMMARY:New Base-Promoted Reductive and Oxidative Coupling Reactions
DESCRIPTION:Abstract: Base-catalyzed reactions typically accomplish redox neutral transformations\, such as the addition of pronucleophiles to electrophiles. Our group is developing mechanistic platforms for base-promoted reductive and oxidative coupling reactions to expand the capabilities of basic chemistry. This talk will discuss the development and synthetic potential of these processes in the context of two methodologies. This includes the reductive defluorinative coupling of trifluoromethylarenes with electrophiles and the oxidative coupling of arenes with nucleophiles. Mechanistic studies will also be included to highlight the generality and future applications of these new base-promoted processes.
URL:https://www.chemistry.ucla.edu/seminars/tba-13/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220203T120000
DTEND;TZID=America/Los_Angeles:20220203T120000
DTSTAMP:20260615T003357
CREATED:20220120T221322Z
LAST-MODIFIED:20220120T221322Z
UID:13595-1643889600-1643889600@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar: Dr. Daniel Straus\, Princeton University
DESCRIPTION:Structural Surprises in Inorganic and Molecular Materials \nEven in some of the most heavily studied materials\, a careful structural analysis can solve stubborn mysteries. The first part of my talk focuses on cesium lead iodide (CsPbI3)\, an inorganic halide perovskite of interest for solar energy conversion that is unstable at room temperature. I use X-ray diffraction measurements to reveal that that the Cs atom rattles within its coordination polyhedron\, causing the material’s thermodynamic instability. Next\, I demonstrate the remarkable emergence of chirality in the self-assembled molecular material C60(SnI4)2\, despite the very high icosahedral and tetrahedral symmetry of its constituent molecules. These results demonstrate that almost any molecular\, nanocrystalline\, or engineered precursor can be considered when designing chiral assemblies\, allowing new classes of optical devices\, asymmetric catalysts\, and biological sensors to be imagined.
URL:https://www.chemistry.ucla.edu/seminars/physical-chemistry-seminar-dr-daniel-straus-princeton-university/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220202T160000
DTEND;TZID=America/Los_Angeles:20220202T160000
DTSTAMP:20260615T003357
CREATED:20220114T184330Z
LAST-MODIFIED:20220114T184330Z
UID:13593-1643817600-1643817600@www.chemistry.ucla.edu
SUMMARY:Chem 278: Special Inorganic Chemistry Seminar - Dr. Matthew Nava
DESCRIPTION:“Elucidation of Reactive Species and Biological Processes Enabled by Molecular Design” 
URL:https://www.chemistry.ucla.edu/seminars/chem-278-special-inorganic-chemistry-seminar-dr-matthew-nava/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220201T103000
DTEND;TZID=America/Los_Angeles:20220201T103000
DTSTAMP:20260615T003357
CREATED:20220126T165115Z
LAST-MODIFIED:20220126T165115Z
UID:13601-1643711400-1643711400@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday\, February 1st\, 2022 at 10:30 AM. We are pleased to invite all students\, postdocs\, faculty\, and staff.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-10/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220201T103000
DTEND;TZID=America/Los_Angeles:20220201T103000
DTSTAMP:20260615T003357
CREATED:20220125T231016Z
LAST-MODIFIED:20220125T231016Z
UID:13599-1643711400-1643711400@www.chemistry.ucla.edu
SUMMARY:Combining Synthetic Chemistry and Biology for Streamlining Access to Complex Molecules
DESCRIPTION:Abstract: By virtue of their unrivaled selectivity profiles\, enzymes possess remarkable potential to address unsolved challenges in chemical synthesis. The realization of this potential\, however\, has only recently gained traction. Recent advances in enzyme engineering and genome mining have provided a powerful platform for identifying and optimizing enzymatic transformations for synthetic applications and allowed us to begin formulating novel synthetic strategies and disconnections. This talk will describe our recent efforts in developing a new design language in chemical synthesis that centers on the incorporation of biocatalytic approaches in contemporary synthetic logic. Case studies will focus on the use of this platform in the chemoenzymatic syntheses of complex natural products and also highlight how this platform could serve as a starting point to enable further biological and medicinal chemistry discoveries.
URL:https://www.chemistry.ucla.edu/seminars/combining-synthetic-chemistry-and-biology-streamlining-access-complex-molecules/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220131T160000
DTEND;TZID=America/Los_Angeles:20220131T160000
DTSTAMP:20260615T003357
CREATED:20220120T204427Z
LAST-MODIFIED:20220120T204427Z
UID:13594-1643644800-1643644800@www.chemistry.ucla.edu
SUMMARY:Chem 228: Professor Wei Xiong\, UCSD
DESCRIPTION:Ultrafast Dynamics of Molecular Vibrational Polaritons For Chemistry and Quantum Simulation \nMolecular vibrational polaritons are hybrid half-light\, half-matter quasiparticle. This hybrid quasiparticles not only inherit properties of both photons and matters\, but also processes unique new photonic and molecular phenomena\, including tilting chemical potential landscapes of reactions\, adding new energy transfer pathways and strong photonic interactions. Many of these developments hinge on fundamental understanding of its physical properties of molecular vibrational polaritons. Using pump probe and 2D IR spectroscopy to study vibrational-polaritons\, we obtained results that advance both molecular science and photonics fields. I will discuss a few phenomena of IR molecular vibrational-polaritons: 1.  Cavity-enabled intermolecular energy transfer\, 2. Vibrational strong coupling accelerated barrier crossing events\, and 3. Nonlinear interactions between polaritons resides in neighboring cavities. These results will have significant implications in novel infrared photonic devices\, lasing\, molecular quantum simulation\, as well as new chemistry by tailoring potential energy landscapes. 
URL:https://www.chemistry.ucla.edu/seminars/chem-228-professor-wei-xiong-ucsd/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220131T160000
DTEND;TZID=America/Los_Angeles:20220131T160000
DTSTAMP:20260615T003357
CREATED:20211217T211915Z
LAST-MODIFIED:20211217T211915Z
UID:13574-1643644800-1643644800@www.chemistry.ucla.edu
SUMMARY:CANCELLED!  Chem 228: Steven Schwartz
DESCRIPTION:“Rare Event Sampling\, Protein Dynamics in enzymatic catalysis and directed evolution: lessons in artificial enzyme design”
URL:https://www.chemistry.ucla.edu/seminars/cancelled-chem-228-steven-schwartz/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220128T153000
DTEND;TZID=America/Los_Angeles:20220128T153000
DTSTAMP:20260615T003357
CREATED:20211217T211439Z
LAST-MODIFIED:20211217T211439Z
UID:13573-1643383800-1643383800@www.chemistry.ucla.edu
SUMMARY:Chem 268 - Dylan T. Burnette
DESCRIPTION:“How does a heart grow? A cell biologist wants to know”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-dylan-t-burnette/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220127T160000
DTEND;TZID=America/Los_Angeles:20220127T160000
DTSTAMP:20260615T003357
CREATED:20210816T221559Z
LAST-MODIFIED:20210816T221559Z
UID:13531-1643299200-1643299200@www.chemistry.ucla.edu
SUMMARY:Postponed
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/tba-12/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220124T160000
DTEND;TZID=America/Los_Angeles:20220124T160000
DTSTAMP:20260615T003357
CREATED:20211217T211232Z
LAST-MODIFIED:20211217T211232Z
UID:13572-1643040000-1643040000@www.chemistry.ucla.edu
SUMMARY:Chem 228: Gerard C. L. Wong
DESCRIPTION:“Molecular biomimicry by the SARS-CoV-2 virus: consequences for severe inflammation\, coagulation\, and dysregulation of antiviral responses”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-gerard-c-l-wong/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220119T160000
DTEND;TZID=America/Los_Angeles:20220119T160000
DTSTAMP:20260615T003357
CREATED:20211215T171745Z
LAST-MODIFIED:20211215T171745Z
UID:13563-1642608000-1642608000@www.chemistry.ucla.edu
SUMMARY:POSTPONED - Chem 278: Prof. Shiyu Zhang
DESCRIPTION:“Modeling Enzymatic Reactivity with Copper Coordination Complexes” \nPOSTPONED
URL:https://www.chemistry.ucla.edu/seminars/postponed-chem-278-prof-shiyu-zhang/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220114T131500
DTEND;TZID=America/Los_Angeles:20220114T131500
DTSTAMP:20260615T003357
CREATED:20211217T210959Z
LAST-MODIFIED:20211217T210959Z
UID:13571-1642166100-1642166100@www.chemistry.ucla.edu
SUMMARY:POSTPONED! Chem 268 - Jennifer Niven Shepherd
DESCRIPTION:“Microbial rhodoquinone biosynthesis proceeds via an atypical RquA-catalyzed amino transfer \nfrom S-adenosyl-L-methionine to ubiquinone” 
URL:https://www.chemistry.ucla.edu/seminars/postponed-chem-268-jennifer-niven-shepherd/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220113T160000
DTEND;TZID=America/Los_Angeles:20220113T160000
DTSTAMP:20260615T003357
CREATED:20220112T232706Z
LAST-MODIFIED:20220112T232706Z
UID:13590-1642089600-1642089600@www.chemistry.ucla.edu
SUMMARY:Stereoselective Gold Catalysis: From Metal-Ligand Cooperation to SN2 Glycosylation
DESCRIPTION:Abstract: Metal-ligand cooperation is a versatile strategy for achieving efficient and/or stereoselective catalysis. Since 2014\, we have developed a range of enabling remotely basic group-functionalized biaryl-2-ylphospine ligands (see Scheme A) for cooperative gold catalysis. With chiral elements built into these ligands\, asymmetric transformations are developed in mechanistically rational manners. DFT calculations confirm the critical participation of the ligand remote basic group in catalysis. Several recent developments will be discussed. This type of bifunctional ligands also enables cooperative catalysis by other metals including Cu and Ag. \nA different yet related approach to achieving stereoselective gold catalysis is developed specifically to address the long-standing challenge in carbohydrate synthesis\, i.e.\, the lack of stereoselective synthesis of glycosidic bonds applicable to every sugar type. In this approach\, as shown in Scheme B\, a basic group is installed onto the anomeric leaving group of the carbohydrate donor and serves to direct the backend attack by a carbohydrate acceptor upon the leaving group activation by gold. The SN2 nature of the glycosylation and the general tolerance of many sugar types make this approach appealing. The progress made in this area will be discussed.
URL:https://www.chemistry.ucla.edu/seminars/stereoselective-gold-catalysis-metal-ligand-cooperation-sn2-glycosylation/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220113T160000
DTEND;TZID=America/Los_Angeles:20220113T160000
DTSTAMP:20260615T003357
CREATED:20210830T220452Z
LAST-MODIFIED:20210830T220452Z
UID:12326-1642089600-1642089600@www.chemistry.ucla.edu
SUMMARY:Postponed: Chapman Lectureship
DESCRIPTION:The Chapman Lecture has been postponed until futher notice. 
URL:https://www.chemistry.ucla.edu/events/postponed-chapman-lectureship/
END:VEVENT
END:VCALENDAR