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X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220316T143000
DTEND;TZID=America/Los_Angeles:20220316T143000
DTSTAMP:20260614T130219
CREATED:20220104T215406Z
LAST-MODIFIED:20220104T215406Z
UID:12328-1647441000-1647441000@www.chemistry.ucla.edu
SUMMARY:Catalysis Lectureship 2022 - Christophe Copéret\, ETH Zürich
DESCRIPTION:Bridging the gap between well-defined and industrial catalysts via a molecular approach \nIndustrial processes\, in particular large-scale ones\, mostly rely on heterogeneous catalysts. The search for more sustainable processes and the changes in environmental policies impose the continuous development of improved catalyst performances and catalytic processes\, as well as the exploration of alternative routes. However\, due to their inherent complexity\, heterogeneous catalysts are mostly developed empirically rather than through detailed structure – activity relationships as the nature of the active sites are rarely known. \nIn this context\, our group has been interested in understanding and controlling chemistry on surfaces\, with the ultimate goal to generate isolated metal sites with defined chemical environment.[1] This approach has been used to develop highly active and selective single-site catalysts that can overperformed their homogeneous counterparts\, but it can also provide useful information to understand and further develop industrial catalysts[2] or to study much more complex systems such as  supported nanoparticles\, where support effects\, interfaces\, alloying… remain complex to understand at the molecular level. \nThis lecture will be developed around these themes and will show that a careful characterization of surface sites on a molecular level is key to develop high performance catalysts and to bridge the gap between fundamental and applied catalysis.[3] \nReferences: \n1 C. Copéret\, A. Comas-Vives\, M. P. Conley\, D. Estes\, A. Fedorov\, V. Mougel\, H. Nagae\, F. Núñez-Zarur\, P. A. Zhizhko Surface Organometallic and Coordination Chemistry towards Single-Site Heterogeneous Catalysts: Strategies\, Methods\, Structures\, and Activities. Chem. Rev. 2016\, 16\, 323-421. DOI: 10.1021/acs.chemrev.5b00373 \n2 C. Copéret\, F. Allouche\, K. W. Chan\, M. P. Conley\, M. F. Delley\, A. Fedorov\, I. B. Moroz\, V. Mougel\, M. Pucino\, K. Searles\, K. Yamamoto\, P. A. Zhizhko\, Bridging the Gap between Industrial and Well-Defined Supported Catalysts. Angew. Chem. Int. Ed. 2018\, 57\, 6398-6440. DOI: 10.1002/anie.201702387 \n3 a) C. Copéret Single-Sites and Nanoparticles at Tailored Interfaces Prepared via Surface Organometallic Chemistry from Thermolytic Molecular Precursors. Acc. Chem. Res. 2019\, 52\, 1697-1708. DOI: 10.1021/acs.accounts.9b001388. b) Deciphering Metal-Oxide and Metal-Metal Interplay via Surface Organometallic Chemistry: A Case Study with CO2 Hydrogenation to Methanol. S. R. Docherty\, C. Copéret J. Am. Chem. Soc. 2021\, 143\, 6767–6780. DOI: 10.1021/jacs.1c02555. c) Heterogeneous Alkane Dehydrogenation Catalysts Investigated via a Surface Organometallic Chemistry Approach. S. R. Docherty\, L. Rochlitz\, P.-A. Payard\, C. Copéret Chem. Soc. Rev. 2021\, 50\, 5806 – 5822. DOI: 10.1039/d0cs01424a.
URL:https://www.chemistry.ucla.edu/seminars/catalysis-lectureship-2022-christophe-coperet-eth-zurich/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220315T123000
DTEND;TZID=America/Los_Angeles:20220315T123000
DTSTAMP:20260614T130219
CREATED:20220310T005937Z
LAST-MODIFIED:20220310T005937Z
UID:13616-1647347400-1647347400@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:“Towards understanding the role of mass transport in electrocatalysis: the role of dimensionless analysis and multi-scale modeling”
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-13/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220311T153000
DTEND;TZID=America/Los_Angeles:20220311T153000
DTSTAMP:20260614T130219
CREATED:20211217T215247Z
LAST-MODIFIED:20211217T215247Z
UID:13583-1647012600-1647012600@www.chemistry.ucla.edu
SUMMARY:Chem 268 - John E. (Jack) Johnson
DESCRIPTION:“Biophysical Studies of an RNA Virus particle and its Maturation: Insights into an Elegantly Programmed Nano-machine”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-john-e-jack-johnson/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220310T160000
DTEND;TZID=America/Los_Angeles:20220310T160000
DTSTAMP:20260614T130219
CREATED:20220302T044201Z
LAST-MODIFIED:20220302T044201Z
UID:13613-1646928000-1646928000@www.chemistry.ucla.edu
SUMMARY:Special Organic Colloquium - Prof. Herman O. Sintim
DESCRIPTION:Novel chemotypes of kinase inhibitors for the potential treatment of recurrent cancers \nAbstract: Therapeutic resistance remains a critical issue in cancer treatment. While cancer patients who harbor dysregulated protein kinases benefit from the use of kinase inhibitors (KIs)\, many fail therapy and almost all patients become resistant to treatment\, indicating a critical unmet need to prevent treatment failure.  \nThus far (as of December 2021)\, the FDA has approved 69 protein kinase inhibitors and several others are also in various stages of clinical trials. Although many compounds that inhibit protein kinases have been described in the literature\, only a small region of the chemical space has been explored for protein kinase inhibition and the majority of FDA approved kinase inhibitors contain only a handful of core moieties\, such as indazole\, quinoline\, isoquinoline\, quinazoline\, pyrazole and pyrimidine. To belabor this point\, about ~20% of FDA-approved protein kinases contain the pyrimidine moiety while six drugs contain quinazoline and eight drugs contain pyrazole. In other words\, about 50% of approved protein kinase inhibitors contain one of pyrimidine\, pyrazole or quinazoline\, highlighting the lack of progress in using other regions of the chemical space to drug protein kinases. The Sintim group\, integrating computational and experimental workflows\, has identified a few novel chemotypes that inhibit disease-associated protein kinases (such as FLT3\, RET\, CDKs\, Haspin) with sub-nanomolar IC50 values. Some of these new KI are long residence time (hours) inhibitors and have shown impressive efficacies in animal models of various cancers. Two of such compounds are currently undergoing toxicology studies to determine safe dosing regimens for potential phase 1 clinical trials against drug-resistant FLT3 (F691L and D835V/Y)-driven AML and RET (solvent front mutations)-driven lung cancers
URL:https://www.chemistry.ucla.edu/seminars/special-organic-colloquium-prof-herman-o-sintim/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220310T120000
DTEND;TZID=America/Los_Angeles:20220310T120000
DTSTAMP:20260614T130219
CREATED:20220304T062605Z
LAST-MODIFIED:20220304T062605Z
UID:13615-1646913600-1646913600@www.chemistry.ucla.edu
SUMMARY:Chem 218: Student Exit Seminar
DESCRIPTION:“Choosing the right lens: Energy surfaces and chemical identity in the photodissociation of Na2+ in different solvent environments”
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220309T160000
DTEND;TZID=America/Los_Angeles:20220309T160000
DTSTAMP:20260614T130219
CREATED:20211215T173626Z
LAST-MODIFIED:20211215T173626Z
UID:13567-1646841600-1646841600@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. James McCusker
DESCRIPTION:“Ultrafast Synthesis: Leveraging Time-resolved Spectroscopy for Targeted Synthetic Control of Ultrafast Dynamics in Transition Metal-based Chromophores” \n Abstract: The interconversion of light and chemical energy is one of the most fundamental processes on Earth. Research on solar energy conversion\, for example – which will ultimately lead to the next generation of solar energy technologies – has sought to replicate Nature’s solution through the realization of artificial constructs that mimic various aspects of photosynthesis. Whether it is the creation of potential gradients to generate current (i.e.\, photovoltaics) or more recent efforts coupling photo-generated electrons and holes to catalysts (e.g.\, photoredox catalysis)\, the critical first step is the absorption of light and the subsequent separation of charge. Transition metal-based chromophores are particularly well-suited for use in such schemes by virtue of the charge-transfer excited-states that a majority of them possess. Indeed\, tremendous advances have been made through use of compounds such as [Ru(bpy)3]2+ and Ir(ppy)3 in areas ranging from solar energy conversion to photoredox catalysis. Despite the obvious advantages of ruthenium- and iridium-based chromophores\, the fact that these elements are among the rarest in the earth’s crust raises legitimate questions concerning cost and scalability of processes reliant on such chromophores. Such issues\, coupled with the possibility of unlocking new chemistry\, has motivated exploring the possibility of replacing these compounds with chromophores based on earth-abundant first-row transition metals that can carry out analogous excited-state reaction chemistry. With these opportunities come significant challenges due to inherent differences in the electronic structures of first- versus second- and third-row metal complexes that profoundly impact the ability of such compounds to engage in the desired chemistry. The focus of our research program is therefore to understand the factors that determine the dynamics associated with charge-transfer excited-states of first-row transition metal-based chromophores\, with the ultimate goal of circumventing and/or redefining their intrinsic photophysics in order to make feasible their use in a variety of light-driven applications. This seminar will outline the key scientific issues defining this challenge as well as discuss recent examples from our lab illustrating how these challenges can be met and\, ultimately\, overcome.
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-james-mccusker/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220307T160000
DTEND;TZID=America/Los_Angeles:20220307T160000
DTSTAMP:20260614T130219
CREATED:20211217T215145Z
LAST-MODIFIED:20211217T215145Z
UID:13582-1646668800-1646668800@www.chemistry.ucla.edu
SUMMARY:Chem 228: Stephen Quake
DESCRIPTION:“The Cell is a Bag of RNA”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-stephen-quake/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220307T150000
DTEND;TZID=America/Los_Angeles:20220307T150000
DTSTAMP:20260614T130219
CREATED:20220303T225028Z
LAST-MODIFIED:20220303T225028Z
UID:13614-1646665200-1646665200@www.chemistry.ucla.edu
SUMMARY:Chem 248 - Organic Chemistry Student Seminar
DESCRIPTION:Recent Advancements in the Employment of Pd/Ni Catalyzed C-N Amide Cross-Coupling
URL:https://www.chemistry.ucla.edu/seminars/chem-248-organic-chemistry-student-seminar-0/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220303T120000
DTEND;TZID=America/Los_Angeles:20220303T120000
DTSTAMP:20260614T130219
CREATED:20220103T212548Z
LAST-MODIFIED:20220103T212548Z
UID:13584-1646308800-1646308800@www.chemistry.ucla.edu
SUMMARY:Postponed - Chem 218: Student Exit Seminar - Samuel Lilak
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/postponed-chem-218-student-exit-seminar-samuel-lilak/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220303T120000
DTEND;TZID=America/Los_Angeles:20220303T120000
DTSTAMP:20260614T130219
CREATED:20210816T221926Z
LAST-MODIFIED:20210816T221926Z
UID:13535-1646308800-1646308800@www.chemistry.ucla.edu
SUMMARY:Organic Colloquium - Prof. Ross Denton
DESCRIPTION:“Phosphorus-Oriented” Method Development and Total Synthesis \nAbstract: The lecture will describe the design\, development and applications of new synthetic methods based upon phosphorus(V) reagents and catalysts. Topics will include catalytic halogenation\, hydroxyl activation and the total synthesis of polychlorinated and trimeric phenol-derived natural products.
URL:https://www.chemistry.ucla.edu/seminars/tba-16/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220302T160000
DTEND;TZID=America/Los_Angeles:20220302T160000
DTSTAMP:20260614T130219
CREATED:20210830T205821Z
LAST-MODIFIED:20210830T205821Z
UID:12325-1646236800-1646236800@www.chemistry.ucla.edu
SUMMARY:2022 M. Frederick Hawthorne Lecture
DESCRIPTION:“Releasing\, or capturing\, that is the question. Porous molecular materials” \nPorous materials are one important class where the shape and distribution of “empty” space throughout the framework is a main determinant for the resulting functionality. For instance\, zeolites are available with many different pore size and geometries\, which is the fundament of their wide spread use in industry\, e.g. as absorbents and catalysts. Drug delivery applications with porous inorganic materials are in the focus of several investigations all over the world. Following supramolecular principles\, i.e.\, incorporating dynamically covalent bonds into a silica framework\, we have reported a “break on-demand” of the silica structure. Recently we have developed disulfide-bridged organosilica nanoparticles with cage-like morphology\, and assessed in detail their bioaccumulation in vivo.[1] Interestingly their lung accumulation and their ability to escape macrophage filtering open new promises for their use as drug delivery systems. \nIn addition they are able to stabilize out of equilibrium species and transport them inside cells were they can be released and evolve towards the equilibrium state.[2] But controlling the shape and the “emptiness”\, of porous systems can allow the capture\, and not release\, of specific molecules\, biomarkers. In particular a novel class of fluorescent artificial receptors (FAR) is introduced that can bind the neurotransmitters serotonin and dopamine in a bio-relevant concentration range with unprecedented affinity and selectivity.[3]  The fully synthetic receptors are based on zeolites and rapid responding and thus enable instantaneous neurotransmitter detection through cost economic and facile absorbance- and emission-based assays. Their potential for high-throughput diagnostics in urine and for monitoring of important enzymatic reactions is shown. \nFinally amongst the most studied porous systems in medicine are hydrogels\, which are inherently more disordered porous system than the aforementioned inorganic host materials. An example of hybrid injectable hydrogels will be given for the treatment of fistula.[4]   \nReferences \n[1]  P. Picchetti et al. ACS Nano 2021\, 15\, 9701–9716 \n[2]  P. Picchetti\, L. De Cola et al. J. Am. Chem. Soc. 2021\, 143\, 7681-7687. \n[3]  F. Biedermann\, L. De Cola et al. Adv. Mater. 2021\, 33\, 2104614. \n[4]  E. Piantanida\, Materials Today Bio\, 2021\, 10\, 100109
URL:https://www.chemistry.ucla.edu/events/2022-m-frederick-hawthorne-lecture/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220301T160000
DTEND;TZID=America/Los_Angeles:20220301T160000
DTSTAMP:20260614T130219
CREATED:20220225T013934Z
LAST-MODIFIED:20220225T013934Z
UID:13611-1646150400-1646150400@www.chemistry.ucla.edu
SUMMARY:Special Organic Colloquium - Prof. Stuart Conway
DESCRIPTION:“The development and targeting of epigenetic drugs for therapeutic benefit” \nAbstract: The talk will comprise two interconnected parts describing the development and targeting of epigenetic drugs for the treatment of disease.  \nThe development of bromodomain ligands for the treatment of disease: bromodomains\, protein modules that ‘read’ of lysine acetylation state\, have emerged as important therapeutic targets for indications including oncology. I will describe our work on the design and synthesis of inhibitors for the BET and CREBBP/EP300 bromodomains\, their biological effects\, and their role as leads for cancer drug discovery. While the function of some human bromodomain-containing proteins (BCPs) has been heavily investigated\, little is known about the role of these proteins in other species. I will describe work to identify 22 BCPs in Schistosoma mansoni (schistosomiasis/bilharzia). We have annotated one of these proteins as SmBRD3\, in analogy to human BRD3\, a member of the BET bromodomain family. I will discuss the design\, synthesis\, and validation of high affinity ligands for SmBRD3 and the use of these ligands in phenotypic studies on S. mansoni.  \nTargeting and imaging tumour hypoxia: Tumor hypoxia (low oxygen) is associated with therapy resistance and poor patient prognosis. Hypoxia-activated prodrugs\, which target oxygen-deficient cells\, represent a promising treatment strategy. We have demonstrated the pre-clinical efficacy of NI-Pano\, a novel hypoxia-activated pro-drug of the clinically used lysine deacetylase inhibitor\, panobinostat. NI-Pano is stable in normoxic (21% oxygen) conditions and undergoes NADPH-CYP-mediated enzymatic bioreduction to release panobinostat in hypoxia (<0.1% oxygen). NI-Pano exhibited growth delay effects as a single agent in mouse tumor xenografts. Pharmacokinetic analysis confirmed the presence of panobinostat in hypoxic mouse xenografts\, but not in circulating plasma or kidneys. Our preclinical results provide a strong mechanistic rationale for the clinical development of NI-Pano for selective targeting of hypoxic tumors. Work to develop complementary imaging agents for hypoxia will also be discussed.
URL:https://www.chemistry.ucla.edu/seminars/special-organic-colloquium-prof-stuart-conway/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220301T130000
DTEND;TZID=America/Los_Angeles:20220301T130000
DTSTAMP:20260614T130219
CREATED:20220223T185306Z
LAST-MODIFIED:20220223T185306Z
UID:13610-1646139600-1646139600@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:“2D Particle Surfactants and Pickering Emulsions for Reagent Compartmentalization”
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-12/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220301T110000
DTEND;TZID=America/Los_Angeles:20220301T110000
DTSTAMP:20260614T130219
CREATED:20220223T182222Z
LAST-MODIFIED:20220223T182222Z
UID:13609-1646132400-1646132400@www.chemistry.ucla.edu
SUMMARY:Chem 228: Prof. Denis Usvyat
DESCRIPTION:“High-accuracy Theoretical Treatment of Defects in Periodic Systems”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-prof-denis-usvyat/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220228T160000
DTEND;TZID=America/Los_Angeles:20220228T160000
DTSTAMP:20260614T130219
CREATED:20211217T215021Z
LAST-MODIFIED:20211217T215021Z
UID:13581-1646064000-1646064000@www.chemistry.ucla.edu
SUMMARY:Chem 228: Robijn Bruinsma
DESCRIPTION:“Physics and the HIV-1 virus”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-robijn-bruinsma/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220228T150000
DTEND;TZID=America/Los_Angeles:20220228T150000
DTSTAMP:20260614T130219
CREATED:20220225T193628Z
LAST-MODIFIED:20220225T193628Z
UID:13612-1646060400-1646060400@www.chemistry.ucla.edu
SUMMARY:Chem 248 - Organic Chemistry Student Seminar
DESCRIPTION:Harnessing Bifunctional Ligands for Regioselective C–H Bond Functionalization
URL:https://www.chemistry.ucla.edu/seminars/chem-248-organic-chemistry-student-seminar/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220225T153000
DTEND;TZID=America/Los_Angeles:20220225T153000
DTSTAMP:20260614T130219
CREATED:20211217T214513Z
LAST-MODIFIED:20211217T214513Z
UID:13579-1645803000-1645803000@www.chemistry.ucla.edu
SUMMARY:Chem 268 - Hung Ton-That
DESCRIPTION:“Sortase-catalyzed surface assembly in monoderm bacteria”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-hung-ton/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220224T160000
DTEND;TZID=America/Los_Angeles:20220224T160000
DTSTAMP:20260614T130219
CREATED:20220217T164804Z
LAST-MODIFIED:20220217T164804Z
UID:13607-1645718400-1645718400@www.chemistry.ucla.edu
SUMMARY:Insight-Driven Strategies in Catalysis for Selective Functionalizations
DESCRIPTION:Abstract: Detailed understanding of catalytic transformations is key to designing better catalysts and overcome pertinent challenges in synthesis. This talk will give insights on case studies and reactivity designs recently undertaken in our laboratory. The focus will be on multinuclear metal catalysis for the chemoselective and modular construction of molecules\, the exploration of organogermanes in catalysis\, and the development of synthetic strategies towards novel fluorinated motifs. Experimental and computational tools were applied in these studies.
URL:https://www.chemistry.ucla.edu/seminars/insight-driven-strategies-catalysis-selective-functionalizations/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220223T160000
DTEND;TZID=America/Los_Angeles:20220223T160000
DTSTAMP:20260614T130219
CREATED:20211215T172746Z
LAST-MODIFIED:20211215T172746Z
UID:13566-1645632000-1645632000@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Sara Skrabalak - MilliporeSigma Inorganic Nano-Materials Lecture
DESCRIPTION:“Multimetallic Nanomaterials by Design”
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-sara-skrabalak-milliporesigma-inorganic-nano-materials-lecture/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220222T103000
DTEND;TZID=America/Los_Angeles:20220222T103000
DTSTAMP:20260614T130219
CREATED:20220217T165406Z
LAST-MODIFIED:20220217T165406Z
UID:13608-1645525800-1645525800@www.chemistry.ucla.edu
SUMMARY:Chemistry at the Biomedicine Interface: Synthesis and Catalysis
DESCRIPTION:Abstract: Chemical reactivity can be utilized in many ways\, including to improve synthetic access to new molecules and to devise tools to advance biomedicine. ‘Synthesis and catalysis’ are two themes interwoven throughout this presentation\, which describes 1) the development of short synthetic routes to (–)-picrotoxinin\, (–)-picrotin\, and 5-methyl-picrotoxinin enabled by a late-stage strong-bond activation strategy for the long term goal of interrogating GABAa receptor combinatorial diversity\, 2) the development of three methods for alkene hydrofunctionalization using Mn- and Co- hydrogen atom transfer chemistry\, and 3) two studies in catalysis centered on one-carbon metabolism which improve understanding of how one-carbon metabolites contribute to health and disease.
URL:https://www.chemistry.ucla.edu/seminars/chemistry-biomedicine-interface-synthesis-and-catalysis/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220218T153000
DTEND;TZID=America/Los_Angeles:20220218T153000
DTSTAMP:20260614T130219
CREATED:20220105T195505Z
LAST-MODIFIED:20220105T195505Z
UID:13588-1645198200-1645198200@www.chemistry.ucla.edu
SUMMARY:Chem 268 - Jennifer Niven Shepherd
DESCRIPTION:“Characterization of RquA – a novel enzyme used in microbial rhodoquinone biosynthesis”  
URL:https://www.chemistry.ucla.edu/seminars/chem-268-jennifer-niven-shepherd/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220217T160000
DTEND;TZID=America/Los_Angeles:20220217T160000
DTSTAMP:20260614T130219
CREATED:20210816T221749Z
LAST-MODIFIED:20210816T221749Z
UID:13534-1645113600-1645113600@www.chemistry.ucla.edu
SUMMARY:Searching for Selective Catalytic Reactions in Complex Molecular Environments
DESCRIPTION:Abstract: This lecture will describe recent developments in our efforts to develop catalysts for asymmetric reactions\, in particular for the preparation of densely functionalized\, stereochemically complex structures. Over time\, our foci have been on enantioselectivity\, site-selectivity and chemoselectivity. In much of our current work\, we are studying issues of enantioselectivity as a prelude to the extrapolation of catalysis concepts to more complex molecular settings where multiple issues are presented in a singular substrate. Mechanistic paradigms\, and their associated ambiguities – especially in light of catalyst or substrate conformational dynamics – will figure strongly in the lecture\, raising analogies to enzymes. Finally\, several interesting – and often unexpected – collaborations with colleagues in industry will be discussed.
URL:https://www.chemistry.ucla.edu/seminars/tba-15/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220217T120000
DTEND;TZID=America/Los_Angeles:20220217T120000
DTSTAMP:20260614T130219
CREATED:20220121T013351Z
LAST-MODIFIED:20220121T013351Z
UID:13597-1645099200-1645099200@www.chemistry.ucla.edu
SUMMARY:Dr. Joonho Lee. Postdoctoral Fellow\, Columbia University/Google Quantum AI  Seminar
DESCRIPTION:Challenging Problems in Quantum Chemistry: How to Diagnose Them and How to Tackle Them \nQuantum chemistry has become an indispensable tool in revealing the microscopic details of molecules and materials such as barrier heights\, interaction energies\, and correlation functions. The nature of electronic correlation is sometimes controversial\, obscuring the optimal choice of quantum chemistry methods with minimal computational effort and the desired accuracy. First\, I will discuss a computational framework that addresses this question using regularized perturbation theory. Second\, I will also discuss several challenging problems beyond the scope of such perturbation theory. I will argue that these problems can be tackled by methods based on auxiliary-field quantum Monte Carlo. Lastly\, I will present my latest development of a new quantum-classical hybrid algorithm in this context\, which represents the largest quantum computation of chemical systems on a quantum computer to date. 
URL:https://www.chemistry.ucla.edu/seminars/dr-joonho-lee-postdoctoral-fellow-columbia-universitygoogle-quantum-ai-seminar/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220216T160000
DTEND;TZID=America/Los_Angeles:20220216T160000
DTSTAMP:20260614T130219
CREATED:20211215T172337Z
LAST-MODIFIED:20211215T172337Z
UID:13565-1645027200-1645027200@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Thomas Kempa
DESCRIPTION:“Precision Synthesis of Quantum Material Building Blocks”
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-thomas-kempa/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220216T140000
DTEND;TZID=America/Los_Angeles:20220216T140000
DTSTAMP:20260614T130219
CREATED:20211217T214747Z
LAST-MODIFIED:20211217T214747Z
UID:13580-1645020000-1645020000@www.chemistry.ucla.edu
SUMMARY:Special Biochem/PChem Seminar - Eitan Lerner
DESCRIPTION:“Structure-function relationship of an unstructured protein – the alpha-Synuclein case”
URL:https://www.chemistry.ucla.edu/seminars/special-biochempchem-seminar-eitan-lerner/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220216T103000
DTEND;TZID=America/Los_Angeles:20220216T103000
DTSTAMP:20260614T130219
CREATED:20220211T184013Z
LAST-MODIFIED:20220211T184013Z
UID:13605-1645007400-1645007400@www.chemistry.ucla.edu
SUMMARY:Investigating Selectivity in Complex Systems: from Total Synthesis to Glycan Labeling
DESCRIPTION:Abstract: The indole diterpenoids constitute a family of natural products that exhibit potent and selective Big Potassium (BK) ion channel inhibition. We have developed a unified synthetic strategy towards the indole diterpenoid class\, culminating in the total synthesis of several representative congeners\, including paspaline A and emindole PB. Density functional theory calculations are utilized to interrogate a simplifying key bond formation in a predictive capacity to aid in the selection of the most favorable precursor substrate. This work highlights how retrosynthetic design can be augmented with quantum chemical calculations to reveal energetically feasible synthetic disconnections\, minimizing time- consuming and expensive empirical evaluation. Furthermore\, these studies provide modular entry to privileged indole diterpenoid class of natural products\, enabling their application as tool compounds for interrogating BK channel dynamics\, as well as therapeutic leads for channelopathies linked to BK channel dysregulation.   \nGlycans are ubiquitous and play important biological roles\, yet chemical methods for probing their structure and function within cells remain limited. Strategies for studying other biomacromolecules\, such as proteins\, often exploit chemoselective reactions for covalent modification\, capture\, or imaging. Unlike amino acids that constitute proteins\, glycan building blocks lack distinguishing reactivity because they are composed primarily of polyol isomers. Moreover\, encoding glycan variants through genetic manipulation is complex. To address these limitations\, we have developed a new\, generalizable strategy for monomer-selective glycan modification that exploits the reactivity of cellular glycosyltransferases by designing reagents with bioorthogonal handles that function as substrate surrogates. Further\, we demonstrate the utility of these labeling reagents by using them to study the biosynthesis\, localization\, and dynamics of cell wall glycans in mycobacteria. 
URL:https://www.chemistry.ucla.edu/seminars/investigating-selectivity-complex-systems-total-synthesis-glycan-labeling/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220215T160000
DTEND;TZID=America/Los_Angeles:20220215T160000
DTSTAMP:20260614T130219
CREATED:20220211T183814Z
LAST-MODIFIED:20220211T183814Z
UID:13604-1644940800-1644940800@www.chemistry.ucla.edu
SUMMARY:Chemical Strategies for Regulating DNA-Interactive Proteins: Targeting APOBEC Cytosine Deaminases and the N-Myc Transcription Factor
DESCRIPTION:Abstract: Our laboratory focuses on the development of small molecule ligands and enzymatic inhibitors of proteins that interact with nucleic acids. We utilize biophysical and biochemical assays to screen chemical libraries to discover protein-binding ligands\, which are then optimized using iterative rounds of molecular design\, synthesis\, and biological evaluation. Our overarching goals are to develop chemical probes to enable the discovery of new biology by the biomedical research community\, as well as develop novel and patentable therapeutic compounds for clinical development by a pharmaceutical partner. In this vein\, two programs from our laboratory\, the discovery of APOBEC inhibitors and N-Myc degraders\, will be presented. \nAPOBEC enzymes are a family of 7 human DNA cytosine-to-uracil deaminases that degrade foreign DNA as part of the innate immune response to pathogen infection. However\, APOBEC enzymes have been shown to contribute C-to-U/T mutations that enable virus and cancer cell genomic mutations that confer resistance to drug therapies. Consequently\, small molecule APOBEC inhibitors may have utility as “anti-mutation” therapies that slow or prevent the evolution of resistance mutations that defeat targeted drug therapies. Our work to develop first-in-class APOBEC inhibitors will be presented. \nThe Myc family of transcription factors are master regulators of proliferation in the majority of human cancers. In the case of childhood neuroblastomas\, which are the most prevalent cancer in children under 1-year of age\, N-Myc is a validated therapeutic target and molecular diagnostic. A vulnerability of N-Myc in many neuroblastomas is that N-Myc is stabilized from proteolytic degradation by Aurora kinase A (Aurora-A). We have developed novel chemical degraders of Aurora-A\, such as HLB-0532259\, that elicit the degradation of Aurora-A and the concomitant degradation of N-Myc. HLB-0532259 also exhibits potent antiproliferative activity in neuroblastoma cells and xenograft mouse models. Our work to develop novel N-Myc degraders will be presented.
URL:https://www.chemistry.ucla.edu/seminars/chemical-strategies-regulating-dna-interactive-proteins-targeting-apobec-cytosine/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220214T160000
DTEND;TZID=America/Los_Angeles:20220214T160000
DTSTAMP:20260614T130219
CREATED:20211217T214351Z
LAST-MODIFIED:20211217T214351Z
UID:13578-1644854400-1644854400@www.chemistry.ucla.edu
SUMMARY:Chem 228: David Pine
DESCRIPTION:“Self-assembly of colloidal diamond for photonics”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-david-pine/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220211T153000
DTEND;TZID=America/Los_Angeles:20220211T153000
DTSTAMP:20260614T130219
CREATED:20211217T213646Z
LAST-MODIFIED:20211217T213646Z
UID:13577-1644593400-1644593400@www.chemistry.ucla.edu
SUMMARY:Chem 268 - David Moffet
DESCRIPTION:“Untangling Amyloid: Slowing the Progression of Type 2 Diabetes”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-david-moffet/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220210T160000
DTEND;TZID=America/Los_Angeles:20220210T160000
DTSTAMP:20260614T130219
CREATED:20210816T221714Z
LAST-MODIFIED:20210816T221714Z
UID:13533-1644508800-1644508800@www.chemistry.ucla.edu
SUMMARY:Battery-Inspired Strategies for Electrocatalytic C–C and C–N Bond-Forming Reactions
DESCRIPTION:Abstract: The seminar will describe our efforts towards the development of scalable\, mild\, and general electrosynthetic methodologies for C–C and C–N/X coupling reactions. These electrosynthetic methodologies are largely possible because of a synergy between redox-active mediators developed by the energy storage community and transition metal catalysts. It will be shown that yields from electrocatalytic reactions are greatly improved by the incorporation of co-catalytic quantities of soluble battery compounds that mediate electron transfer with the coupling catalyst or protect the coupling catalyst from over-oxidation/reduction and degradation. \nEmploying mediators with properly tuned redox potentials and electron-transfer kinetics\, we demonstrate electrocatalytic cross-electrophile coupling reactions of (hetero) aryl halides and alkyl halides that represent the state of the art in the area. Additionally\, we demonstrate a broad scope for Chan-Lam coupling of amines and arylboronic acids in the absence of a chemical oxidants. Our studies reveal unique mechanisms that are only accessible under electrochemical conditions that enable cross coupling of tertiary electrophiles or arylchlorides: challenging substrates that are currently incompatible with any form of reductive activation.
URL:https://www.chemistry.ucla.edu/seminars/tba-14/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
END:VCALENDAR