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X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
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BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
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TZOFFSETFROM:-0700
TZOFFSETTO:-0800
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DTSTART:20211107T090000
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210312T153000
DTEND;TZID=America/Los_Angeles:20210312T153000
DTSTAMP:20260615T141555
CREATED:20210104T172741Z
LAST-MODIFIED:20210104T172741Z
UID:13405-1615563000-1615563000@www.chemistry.ucla.edu
SUMMARY:CANCELLED - Chem 268: Prof. Hernan Garcia
DESCRIPTION:“Dissecting Transcriptional Dynamics in Development One Burst at a Time”
URL:https://www.chemistry.ucla.edu/seminars/cancelled-chem-268-prof-hernan-garcia/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210311T130000
DTEND;TZID=America/Los_Angeles:20210311T130000
DTSTAMP:20260615T141555
CREATED:20210304T164257Z
LAST-MODIFIED:20210304T164257Z
UID:13447-1615467600-1615467600@www.chemistry.ucla.edu
SUMMARY:CIC Careers in Green Chemistry Seminar Series
DESCRIPTION:The Center for Integrated Catalysis is hosting a new seminar series called the “Careers in Green Chemistry.” With these webinars\, we aim to bring speakers from a wide variety of careers\, linked through green chemistry\, to come talk about their current job as well as the career path that led them to that position. We are pleased to invite all students\, postdocs\, and faculty.
URL:https://www.chemistry.ucla.edu/seminars/cic-careers-green-chemistry-seminar-series/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210311T120000
DTEND;TZID=America/Los_Angeles:20210311T120000
DTSTAMP:20260615T141555
CREATED:20210120T173102Z
LAST-MODIFIED:20210120T173102Z
UID:13430-1615464000-1615464000@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: David Reilley
DESCRIPTION:Chemical Change in Protein Molecular Dynamics: Developing Computational Tools for Metal Binding and pH Sensitivity \n Molecular dynamics (MD) is a powerful tool to study atomic scale changes in proteins underpinning biological pathways. However\, simulations traditionally sample a fixed chemical state and struggle to achieve quantitatively accurate energies\, making comparisons of different chemical ensembles challenging. Hybrid quantum mechanical-classical approaches (QM/MM) can provide accurate energies for small regions of interest\, such as the active site\, but cannot readily capture all chemical transformations relevant to protein function. This talk will focus on developments and applications of hybrid methods to study the metal binding preferences and pH sensitivity of proteins. We will first discuss how we used QM/DMD combined with a competitive metal affinity method\, a semi-empirical thermodynamic cycle\, to obtain relative binding affinities for a wide range of metals to human serum transferrin (hTF)\, an iron transport protein. Our results clarified a mechanism for promiscuous metal binding in hTF and the role the protein may play in transport of non-physiological and potentially cytotoxic metals. We will then discuss the development of a titration feature for constant pH simulations with DMD (titr-DMD). Our method features stochastic protonation and deprotonation of amino acids while treating solvent implicitly\, which makes it computationally efficient compared to other techniques. We successfully benchmarked titr-DMD on experimentally verified pH-dependent conformational changes. Our work demonstrates the utility of molecular dynamics\, and QM/DMD in particular\, to study chemical changes in proteins with good accuracy and speed.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-david-reilley/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210310T160000
DTEND;TZID=America/Los_Angeles:20210310T160000
DTSTAMP:20260615T141555
CREATED:20210120T172051Z
LAST-MODIFIED:20210120T172051Z
UID:13425-1615392000-1615392000@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Long Luo
DESCRIPTION:Electrifying Inorganic and Organic Synthesis \nAbstract: Electrochemical synthesis is a powerful tool for formulating functional materials and moleculesbecause it offers an additional level of control over the synthesis relative to its chemical counterpart by fine-tuning mass transfer\, potential\, or current. Electrochemical synthesis also allows the convenient analysis of chemical reaction thermodynamics and kinetics using the current signal generated during the electrochemical synthesis. In this talk\, two recent advancements in electrochemical synthesis will be presented: (1) Electrochemical gelation of nanoparticles and (2) Alternating current electrolysis for organic synthesis. 
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-long-luo/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210310T120000
DTEND;TZID=America/Los_Angeles:20210310T120000
DTSTAMP:20260615T141555
CREATED:20210304T164531Z
LAST-MODIFIED:20210304T164531Z
UID:13448-1615377600-1615377600@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Wenfei Li
DESCRIPTION:Developing Highly Efficient Electronic Structure Theory Methods for Large Scale Simulations \n Electronic structure simulations are now becoming an indispensable tool in chemistry research. The overall goal is to develop methods that give accurate results without sacrificing efficiency. In our group\, we incorporate various computational techniques to drastically reduce the cost of simulations. This allows us to run large scale simulations that were not previously possible. Our major innovation is stochastic quantum chemistry\, where we replaced the summation over thousands of deterministic orbitals to an average over much smaller number of stochastic orbitals\, and sometimes only a few suffices. This leads to significant increase in efficiency. In this seminar\, I will talk about my two projects under the stochastic quantum chemistry framework. The first project involved developing an embedding stochastic framework\, where a sub-system of interest is treated using deterministic orbitals\, while the rest of the system is treated using stochastic orbitals. This way\, we can selectively reduce the stochastic errors associated with that sub-system. The second project involved finding an optimal DFT starting point for our stochasticGW code. Apart from that\, I will also introduce our orthogonal projector augmented wave package. Compared with the norm-conserving pseudopotential approach\, the PAW method will allow a lower kinetic energy cutoff\, hence greatly enhances the efficiency of electronic structure theory simulations.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-wenfei-li/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210308T160000
DTEND;TZID=America/Los_Angeles:20210308T160000
DTSTAMP:20260615T141555
CREATED:20210120T182725Z
LAST-MODIFIED:20210120T182725Z
UID:13435-1615219200-1615219200@www.chemistry.ucla.edu
SUMMARY:Chem 228: Peter Dahlberg\, Ph.D.
DESCRIPTION:“Combining cryogenic single-molecule fluorescence measurements and CryoEM: New methods with applications from biology to physical chemistry”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-peter-dahlberg-phd/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210305T133000
DTEND;TZID=America/Los_Angeles:20210305T133000
DTSTAMP:20260615T141555
CREATED:20210104T172651Z
LAST-MODIFIED:20210104T172651Z
UID:13403-1614951000-1614951000@www.chemistry.ucla.edu
SUMMARY:Chem 268: Prof. Benjamin Falcon
DESCRIPTION:“Amyloid conformers in neurodegenerative disease”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-prof-benjamin-falcon/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210304T160000
DTEND;TZID=America/Los_Angeles:20210304T160000
DTSTAMP:20260615T141555
CREATED:20210120T235559Z
LAST-MODIFIED:20210120T235559Z
UID:13438-1614873600-1614873600@www.chemistry.ucla.edu
SUMMARY:Break-it-to-Make-it Strategies for Chemical Synthesis Inspired by Complex Natural Products”
DESCRIPTION:Abstract: Natural products continue to inspire and serve as the basis of new medicines. They also provide intricate problems that expose limitations in the strategies and methods employed in chemical synthesis. Several strategies and methods that have been developed in our laboratory and applied to the syntheses of architecturally complex diterpenoid alkaloids\, indole alkaloids\, and several Lycopodium alkaloids\, will be discussed. In addition\, new ways to employ C–C bond cleavage in synthesis will be presented (i.e.\, break-it-to-make-it strategies).
URL:https://www.chemistry.ucla.edu/seminars/break-it-make-it-strategies-chemical-synthesis-inspired-complex-natural-products/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210304T120000
DTEND;TZID=America/Los_Angeles:20210304T120000
DTSTAMP:20260615T141555
CREATED:20210120T172927Z
LAST-MODIFIED:20210120T172927Z
UID:13429-1614859200-1614859200@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Sophia King
DESCRIPTION:Controlling the Architecture of Nanoporous Materials to Regulate their Thermal Conductivity and Optical Transparency for Energy Efficient Windows \n Transparent\, low thermal conductivity coatings can be applied to windows to increase the energy efficiency of buildings. Amorphous material such as silica make good thermal insulators due to their local atomic disorder that impedes heat conduction. Moreover\, pores can be added to the material to further reduce heat conduction by decreasing the material density while adding interfaces can additionally scatter heat carriers. This concept is often used in highly porous silica aerogels\, which are valued for their ultra-low thermal conductivities. However\, these aerogels significantly scatter light\, and therefore cannot be used for applications that require high optical transparency. This talk focuses on our ongoing efforts to design silica-based coating that are insulating as well as optically transparent. First\, I will describe our efforts using mesoporous thin films to expand on our fundamental understanding of heat transport in nanoporous\, silica-based materials. Next\, I will discuss how the knowledge gained from these thin film studies influenced our design of novel precursors and a scalable synthetic method to produce monoliths that can be used in thermal insulation applications. Finally\, I will describe our efforts to use small angle X-ray scattering (SAXS) to follow structural changes in porous materials with the goal of understanding how surface chemistry and drying dynamics influence pore structure to produce materials with desired thermal conductivity and optical quality.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-sophia-king/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210303T160000
DTEND;TZID=America/Los_Angeles:20210303T160000
DTSTAMP:20260615T141555
CREATED:20210120T171640Z
LAST-MODIFIED:20210120T171640Z
UID:13424-1614787200-1614787200@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Sheng Xu
DESCRIPTION:Controlled epitaxial growth and fabrication of hybrid halide perovskites \nAbstract: Organic–inorganic hybrid halide perovskites have demonstrated tremendous potential for next-generation electronic and optoelectronic devices due to their remarkable carrier dynamics. Current studies are mostly focused on polycrystals\, since controlled growth of high-quality single crystals is challenging. In this presentation\, I will discuss strategies that enabled the first chemical epitaxial growth of single-crystal hybrid halide perovskites. Using advanced microfabrication\, homo-/hetero-epitaxy\, and a low-temperature solution method\, single crystals can be grown with controlled locations\, morphologies\, orientations\, and strain levels. By a lifting off approach\, single-crystal thin films can be transferred from the epitaxial substrate to a general flexible substrate. This approach opens up broad opportunities for hybrid halide perovskite materials based high-performance electronic and optoelectronic devices.
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-sheng-xu/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210303T123000
DTEND;TZID=America/Los_Angeles:20210303T123000
DTSTAMP:20260615T141555
CREATED:20210301T205743Z
LAST-MODIFIED:20210301T205743Z
UID:13446-1614774600-1614774600@www.chemistry.ucla.edu
SUMMARY:Dissertation Seminar: Cliff Boldridge
DESCRIPTION:“Specificity in Protein-Protein Interactions: High-Throughput Characterization of Rationally Designed and Naturally Evolved Coiled-Coil Networks”
URL:https://www.chemistry.ucla.edu/seminars/dissertation-seminar-cliff-boldridge/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210302T120000
DTEND;TZID=America/Los_Angeles:20210302T120000
DTSTAMP:20260615T141555
CREATED:20210225T000105Z
LAST-MODIFIED:20210225T000105Z
UID:13444-1614686400-1614686400@www.chemistry.ucla.edu
SUMMARY:Proximity-enabled Reactivity for Biological Studies
DESCRIPTION:Abstract: To genetically introduce new chemical reactivity into live systems\, we engineered the genetic code to encode a new class of unnatural amino acids (Uaas)\, the latent bioreactive Uaas. These Uaas\, after being incorporated into proteins\, specifically react with target natural amino acid residues via proximity-enabled reactivity\, enabling the selective formation of new covalent linkages within and between proteins both in vitro and in live systems. These diverse reactivities\, inaccessible to natural proteins\, open doors to novel protein engineering\, biological research\, and therapeutic applications. I will present specific examples of using the proximity-enabled reactivity to probe ligand-receptor binding\, to identify elusive protein-protein interactions\, and to develop covalent protein drugs for cancer immunotherapy.
URL:https://www.chemistry.ucla.edu/seminars/proximity-enabled-reactivity-biological-studies/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210301T160000
DTEND;TZID=America/Los_Angeles:20210301T160000
DTSTAMP:20260615T141555
CREATED:20210120T182417Z
LAST-MODIFIED:20210120T182417Z
UID:13434-1614614400-1614614400@www.chemistry.ucla.edu
SUMMARY:Chem 228: Ben Zhong Tang
DESCRIPTION:“Aggregology: Science beyond Molecules”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-ben-zhong-tang/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210226T153000
DTEND;TZID=America/Los_Angeles:20210226T153000
DTSTAMP:20260615T141555
CREATED:20210104T172543Z
LAST-MODIFIED:20210104T172543Z
UID:13402-1614353400-1614353400@www.chemistry.ucla.edu
SUMMARY:Chem 268: Prof. Martin Kampmann
DESCRIPTION:“Elucidating cellular pathways controlling protein aggregation\, spread and toxicity in neurodegenerative disease”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-prof-martin-kampmann/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210225T160000
DTEND;TZID=America/Los_Angeles:20210225T160000
DTSTAMP:20260615T141555
CREATED:20210120T201235Z
LAST-MODIFIED:20210120T201235Z
UID:13437-1614268800-1614268800@www.chemistry.ucla.edu
SUMMARY:New Strategies for the Efficient Preparation of Bioactive Compounds
DESCRIPTION:Abstract: Novel technologies\, preparative methods and synthetic strategies often represent a critical part of the investigation of new design ideas for bioactive compounds. Traditionally\, natural products were considered to be the most challenging targets\, but frequently medicinal chemistry structure-activity relationship (SAR) studies are also limited in practice by synthetic tractability. This presentation will select two to three topics from currently ongoing projects in our group that have benefited from key contributions from technological\, methodological\, and strategic innovations. \nFor example\, we have recently reported the synthesis of iminothienopyridinediones through photooxygenation reactions. Our lead structure in this series was found to be a potent inhibitor of the oncogenic\, dual-specific phosphatase PTP4A3 (in vitro IC50 ~35 nM)\, as well as its family members PTP4A1 and PTP4A2. The SAR analysis as well as the scale-up of the iminothienopyridinedione chemotype were greatly facilitated by in-flow techniques\, first using fluoroelastomer tubing and a compact fluorescent lamp (CFL)\, and then a 3-D printed polypropylene cartridge system under LED light irradiation. \nAnother case study to be presented focuses on strategic innovations in the total synthesis and the investigation of the CNS/GPCR effects of Ergot Alkaloids. In particular\, the influence of scaffold rearrangement and stereochemistry on the serotonin (5-HT) receptor modulation of Ergot Alkaloid analogs will be highlighted\, a biological property that is significant for their potential for future development as anti-depression and anti-anxiety pharmaceuticals.
URL:https://www.chemistry.ucla.edu/seminars/new-strategies-efficient-preparation-bioactive-compounds/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210225T120000
DTEND;TZID=America/Los_Angeles:20210225T120000
DTSTAMP:20260615T141555
CREATED:20210120T172737Z
LAST-MODIFIED:20210120T172737Z
UID:13428-1614254400-1614254400@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Dane Stanfield
DESCRIPTION:A Tale of Two Doping Mechanisms: Controlling the Formation of Charge Transfer Complexes in Chemically Doped Semiconducting Polymers \nDoping of organic semiconductors has emerged as a viable route for the inexpensive fabrication of numerous electronic devices such as light emitting diodes\, thin film transistors\, and thermoelectric generators. The p-type doping of polymer based semiconductors like P3HT is achieved through the introduction of chemically strong oxidizing agents like F4TCNQ that usually undergo integer charge transfer\, removing an electron from the extended  conjugation network\, leaving behind a charged hole in its place that is free to conduct at the bulk level. In contrast\, p-type doping of small molecule based semiconductors typically results in formation of charge transfer complexes\, where close spatial contact and orbital overlap between the host and guest species cause fractional charge transfer to occur. It has to date remained unclear why polymeric based semiconductors show a preference for doping via integer charge transfer while their small molecule counterparts usually undergo formation of fractional charge transfer complexes. In this talk\, we will discuss recent advances in our understanding of the mechanisms that drive these two different types of charge transfer interactions in conjugated polymers. We show that it is possible to exert control over the type and abundance of each type of charge transfer interaction through the simple selection of processing solvent solubility parameters. We are also able to assign two structurally unique packing arrangements that correspond to integer or fractional charge transfer and compare the relative thermal stabilities of these two polymorphs. Finally\, we show that the CN groups found on the dopant molecule\, F4TCNQ\, can serve as a probe of the local electric field strength and thus the environment of the charge carriers as detected via the vibrational stark effect. Overall\, this improved understanding of polymer-dopant interactions allows us to provide new guidelines for enhancing the doping efficiency and limiting the occurrence of fractional charge transfer states in doped semiconducting polymers.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-dane-stanfield/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210224T160000
DTEND;TZID=America/Los_Angeles:20210224T160000
DTSTAMP:20260615T141555
CREATED:20210120T171328Z
LAST-MODIFIED:20210120T171328Z
UID:13423-1614182400-1614182400@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Anne McNeil
DESCRIPTION:Synthetic Approaches to Sustainable Polymers \nAbstract: Plastics have completely transformed our lives\, while at the same time having a significant negative impact on our environment. Our research is aimed at developing synthetic approaches to more sustainable polymers. This talk will highlight two projects ongoing within our group. In one\, we aim to make a processable\, thermoplastic that fully degrades back to monomer after use in a fully closed loop. In the other\, we aim to use synthetic chemistry to give a current high-production-volume plastic a second life\, attenuating its impact on the environment.
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-anne-mcneil/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210224T130000
DTEND;TZID=America/Los_Angeles:20210224T130000
DTSTAMP:20260615T141555
CREATED:20210219T004529Z
LAST-MODIFIED:20210219T004529Z
UID:13443-1614171600-1614171600@www.chemistry.ucla.edu
SUMMARY:Special Biochemistry Seminar: Dr. Anum Glasgow
DESCRIPTION:“Building dynamic\, functional proteins to understand and treat disease”
URL:https://www.chemistry.ucla.edu/seminars/special-biochemistry-seminar-dr-anum-glasgow/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210223T120000
DTEND;TZID=America/Los_Angeles:20210223T120000
DTSTAMP:20260615T141555
CREATED:20210217T001407Z
LAST-MODIFIED:20210217T001407Z
UID:13442-1614081600-1614081600@www.chemistry.ucla.edu
SUMMARY:Medicinal Chemistry and Pharmacology of Antivirals Targeting Influenza Virus\, Enterovirus D68\, and SARS-CoV-2
DESCRIPTION:Abstract: Respiratory viruses pose a persistent threat to public health and global economy. However\, there is a lack of effective antiviral countermeasures against many of these highly transmissible pathogens. In this presentation\, I will present a few projects on the development of small molecule antivirals against the influenza virus\, enterovirus D68 (EV-D68)\, and SARS-CoV-2. Throughout the talk\, I will discuss the experience and lessons learned from academic drug discovery including target identification\, hit prioritization\, and translational research. For influenza virus project\, we have developed antivirals targeting the viral M2-S31N proton channel and the viral polymerase PA-PB1 interactions. The lead compounds have shown potent in vitro and in vivo antiviral activity against both Tamiflu-sensitive and resistant influenza viruses. EV-D68 is a respiratory virus that mainly infect children and cause flu-like symptoms. In severe cases\, the infection can lead to neurological symptoms called acute flaccid myelitis. There is currently no antiviral or vaccine available for EV-D68. We have made promising progress in developing antivirals targeting the viral VP1 capsid\, the 2A protease and the 2C protein. The lead compounds have shown broad-spectrum antiviral activity against multiple enteroviruses including poliovirus. For the SARS-CoV-2 project\, we are among the first to discover structurally diverse compounds as the viral main protease (Mpro) inhibitors and have solved multiple X-ray crystal structures. Subsequent structure-based drug design led to the discovery of the both covalent and non-covalent Mpro inhibitors with potent enzymatic inhibition and cellular antiviral activity. Overall\, the lead compounds we have developed against influenza virus\, EV-D68\, and SARS-CoV-2 have promising translational potential and continuous development might lead to the first-in-class broad-spectrum antivirals.
URL:https://www.chemistry.ucla.edu/seminars/medicinal-chemistry-and-pharmacology-antivirals-targeting-influenza-virus-enterovirus-d68/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210222T160000
DTEND;TZID=America/Los_Angeles:20210222T160000
DTSTAMP:20260615T141555
CREATED:20210104T181340Z
LAST-MODIFIED:20210104T181340Z
UID:13408-1614009600-1614009600@www.chemistry.ucla.edu
SUMMARY:Chem 228: Prof. Deji Akinwande
DESCRIPTION:“Adventures with Atomic Materials: from Flexible/Wearable Electronics to Memory Devices”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-prof-deji-akinwande/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210218T160000
DTEND;TZID=America/Los_Angeles:20210218T160000
DTSTAMP:20260615T141555
CREATED:20210120T193820Z
LAST-MODIFIED:20210120T193820Z
UID:13436-1613664000-1613664000@www.chemistry.ucla.edu
SUMMARY:Recent progress in the discovery of non-hormonal male contraceptive agents
DESCRIPTION:Abstract: There is a global need for novel contraceptive methods because worldwide about 40% of pregnancies are still unintended\, about 42 million pregnancies are terminated by abortion\, and 658 women per day die of pregnancy-related problems in the US (CDC 2020). While many contraceptive options exist for women\, fewer are available for men. Testosterone-based contraceptives for men have been investigated for 60 years but challenges remain for commercialization. For these reasons and to provide couples with additional safe and reversible options for contraception\, the development of non-hormonal contraceptives for both men and women is highly desirable to assist with family planning and reduce unintended pregnancies. Advances in the understanding of reproductive biology have provided many testis-specific targets that are under investigation for the discovery and development of a male contraceptive agent that involve reduction of sperm counts\, effect spermiation\, prevent sperm maturation\, or block sperm motility. However\, developing agents that are highly effective\, very safe and completely reversible is a very significant challenge. Recent progress on the discovery of inhibitors for the testis-specific bromodomain (BRDT) will be discussed. Based on the discovery that some kinase inhibitors are dual kinase/bromodomain inhibitors (ACS Chem. Biol. 2013\, 8\, 2360 and ACS Chem. Biol. 2014\, 16\, 1160) efforts towards the discovery of selective BRDT monovalent and bivalent BRDT inhibitors will be presented.
URL:https://www.chemistry.ucla.edu/seminars/recent-progress-discovery-non-hormonal-male-contraceptive-agents/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210218T120000
DTEND;TZID=America/Los_Angeles:20210218T120000
DTSTAMP:20260615T141555
CREATED:20210120T172619Z
LAST-MODIFIED:20210120T172619Z
UID:13427-1613649600-1613649600@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Mary Grumbles
DESCRIPTION:“Strategies for Modulating Stabilities of Soft and Hard Hybrid Materials with Boron Clusters” \n Carbon chemistry is ubiquitous across the development of modern materials. In comparison\, use of boron building blocks is underdeveloped\, owing to the historic instability of simple boranes. Polyhedral boranes\, however\, fundamentally differ from their borane precursors and exhibit exceptional chemical stability as a result of three-dimensional\, delocalized aromaticity. My talk will highlight the utility of polyhedral boranes to generate hybrid materials with unique stability profiles. Specifically\, I will discuss the use of polyhedral boranes as matrices for ion shuttling\, highlighting the tolerance of these species to repeated electrochemical cycling in the presence of both moisture and water. After\, I will discuss efforts to amend unprotected peptides with polyhedral boranes. My talk will highlight the distinct physical and chemical properties of the resulting bioconjugates\, emphasizing the ability of these species to slow proteolytic degradation. Finally\, I will describe ongoing efforts within the Spokoyny lab to develop and investigate these hybrid borane materials.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-mary-grumbles/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210217T160000
DTEND;TZID=America/Los_Angeles:20210217T160000
DTSTAMP:20260615T141555
CREATED:20210120T170633Z
LAST-MODIFIED:20210120T170633Z
UID:13422-1613577600-1613577600@www.chemistry.ucla.edu
SUMMARY:OCDS Prof. Tanja Ćuk
DESCRIPTION:Resolving a catalytic mechanism at an electrode surface with high time-resolution:  \nExperimental identification of theoretical descriptors \nAbstract: Catalytic mechanisms at electrode surfaces guide the development of electrochemically-controlled energy storing reactions and chemical synthesis. The intermediate steps of these mechanisms are challenging to identify experimentally\, but are critical to understanding the speed\, stability\, and selectivity of product evolution.  In my group\, we employ photo-triggered vibrational and electronic spectroscopy to time-resolve the catalytic cycle at a surface\, identifying meta-stable intermediates and critical transition states which connect one to another.  The focus is on the highly selective water oxidation reaction at the semiconductor (SrTiO3)-aqueous interface\, triggered by an ultrafast light pulse in an electrochemical cell.  Here\, I will summarize the work done to date by the group: the structure and dynamics of the initial intermediates that trap charge (Ti-O*- and Ti-O*+-Ti) from their picosecond birth at the surface through the next event at microseconds\, suggested to be the formation of the first O-O bond of O2 evolution.  There will be a focus on how time-resolving the intermediates leads to experimental identification of largely theoretical descriptors of oxygen evolution\, such as the binding energy of the first meta-stable\, electron-deficient oxygen intermediates (generally\, M-OH*).  In so doing\, reaction conditions that shift equilibria become an important\, independent axis to the time & energy axes of the spectroscopy.  While many open questions remain\, these experiments provide and benchmark the opportunity to quantify intermediates at an electrode surface and follow a heterogeneous catalytic cycle in time.  
URL:https://www.chemistry.ucla.edu/seminars/ocds-prof-tanja-cuk/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210216T130000
DTEND;TZID=America/Los_Angeles:20210216T130000
DTSTAMP:20260615T141555
CREATED:20210210T231058Z
LAST-MODIFIED:20210210T231058Z
UID:13440-1613480400-1613480400@www.chemistry.ucla.edu
SUMMARY:Special Biochemistry Seminar: Dr. James K. Nuñez
DESCRIPTION:“Programmable transcriptional memory by CRISPR epigenome editing” \n 
URL:https://www.chemistry.ucla.edu/seminars/special-biochemistry-seminar-dr-james-k-nunez/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210216T120000
DTEND;TZID=America/Los_Angeles:20210216T120000
DTSTAMP:20260615T141555
CREATED:20210211T183931Z
LAST-MODIFIED:20210211T183931Z
UID:13441-1613476800-1613476800@www.chemistry.ucla.edu
SUMMARY:Theoretical Chemistry Seminar - Predicting and Controlling Correlated Light-Matter Interactions - Prof. Prineha Narang\, Harvard University
DESCRIPTION:Predicting and Controlling Correlated Light-Matter Interactions \nQuantum systems host spectacular excited-state effects\, but many of these phenomena remain challenging to control and\, consequently\, technologically under-explored. My research\, therefore\, focuses on how quantum systems behave\, particularly away from equilibrium\, and how we can harness these effects1. By creating predictive approaches to study dynamics\, decoherence and photo-induced correlations in molecules and matter\, our work could enable technologies that are inherently more powerful than their classical counterparts ranging from quantum information science\, to ultra-high efficiency optoelectronic and energy conversion systems. In this talk\, I will present work from my research group on describing\, from first principles approaches\, the microscopic dynamics\, decoherence and optically-excited collective phenomena at finite temperature to quantitatively link predictions with 3D atomic-scale imaging\, quantum spectroscopy\, and macroscopic behavior. Capturing these dynamics poses unique theoretical and computational challenges. The simultaneous contribution of processes that occur on many time and length-scales have remained elusive for state-of-the-art calculations and model Hamiltonian approaches alike\, necessitating the development of new methods in theoretical and computational quantum chemistry 2–4. I will introduce our work at the intersection of ab initio cavity quantum-electrodynamics and electronic structure methods to treat electrons\, photons and phonons on the same quantized footing\, accessing new observables in strong light-matter coupling. Building on this\, I will show selected examples of our approach in ab initio design of active defects in quantum materials leveraging the chemical degree-of-freedom5–7 towards selectively linking these active defects 8–10. Finally\, I will present an outlook on driving quantum chemical systems far out-of-equilibrium to control the coupled electronic and vibrational degrees-of-freedom 11–13. \nReferences: \n\nHead-Marsden\, K.\, Flick\, J.\, Ciccarino\, C. J. & Narang\, P. Quantum Information and Algorithms for Correlated Quantum Matter. Chem. Rev. (2020) doi:10.1021/acs.chemrev.0c00620.\nRivera\, N.\, Flick\, J. & Narang\, P. Variational Theory of Nonrelativistic Quantum Electrodynamics. Phys. Rev. Lett. 122\, 193603 (2019).\nFlick\, J.\, Rivera\, N. & Narang\, P. Strong light-matter coupling in quantum chemistry and quantum photonics. Nanophotonics 7\, 1479–1501 (2018).\nFlick\, J. & Narang\, P. Cavity-Correlated Electron-Nuclear Dynamics from First Principles. Physical Review Letters vol. 121 (2018).\nNarang\, P.\, Ciccarino\, C. J.\, Flick\, J. & Englund\, D. Quantum Materials with Atomic Precision: Artificial Atoms in Solids: Ab Initio Design\, Control\, and Integration of Single Photon Emitters in Artificial Quantum Materials. Adv. Funct. Mater. 29\, 1904557 (2019).\nHayee\, F. et al. Revealing multiple classes of stable quantum emitters in hexagonal boron nitride with correlated optical and electron microscopy. Nat. Mater. 19\, 534–539 (2020).\nCiccarino\, C. J. et al. Strong spin–orbit quenching via the product Jahn–Teller effect in neutral group IV qubits in diamond. npj Quantum Materials 5\, 75 (2020).\nNeuman\, T.\, Wang\, D. S. & Narang\, P. Nanomagnonic Cavities for Strong Spin-Magnon Coupling and Magnon-Mediated Spin-Spin Interactions. Phys. Rev. Lett. 125\, 247702 (2020).\nWang\, D. S.\, Neuman\, T. & Narang\, P. Dipole-coupled emitters as deterministic entangled photon-pair sources. Phys. Rev. Research 2\, 043328 (2020).\nNeuman\, T. et al. A Phononic Bus for Coherent Interfaces Between a Superconducting Quantum Processor\, Spin Memory\, and Photonic Quantum Networks. arXiv [quant-ph] (2020).\nJuraschek\, D. M.\, Meier\, Q. N. & Narang\, P. Parametric Excitation of an Optically Silent Goldstone-Like Phonon Mode. Physical Review Letters vol. 124 (2020).\nJuraschek\, D. M.\, Narang\, P. & Spaldin\, N. A. Phono-magnetic analogs to opto-magnetic effects. Phys. Rev. Research 2\, 043035 (2020).\nJuraschek\, D. M.\, Neuman\, T.\, Flick\, J. & Narang\, P. Cavity control of nonlinear phononics. arXiv [cond-mat.mtrl-sci] (2019).
URL:https://www.chemistry.ucla.edu/seminars/theoretical-chemistry-seminar-predicting-and-controlling-correlated-light-matter/
CATEGORIES:Other,Seminars
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210212T153000
DTEND;TZID=America/Los_Angeles:20210212T153000
DTSTAMP:20260615T141555
CREATED:20210104T172448Z
LAST-MODIFIED:20210104T172448Z
UID:13401-1613143800-1613143800@www.chemistry.ucla.edu
SUMMARY:Chem 268: Prof. William DeGrado
DESCRIPTION:“De novo design of function in water-soluble and membrane proteins”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-prof-william-degrado/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210211T120000
DTEND;TZID=America/Los_Angeles:20210211T120000
DTSTAMP:20260615T141555
CREATED:20210120T172449Z
LAST-MODIFIED:20210120T172449Z
UID:13426-1613044800-1613044800@www.chemistry.ucla.edu
SUMMARY:Cancelled Chem 218 Student Exit Seminar: Arundhati Deshmukh
DESCRIPTION:Cancelled \n “Tuning the Excitonic Properties of 2-Dimensional Molecular Aggregates across the Visible and Shortwave Infrared” \n Molecular aggregates are non-covalent self-assemblies of chromophores wherein transition dipole moments of individual molecules couple coherently over long distances\, forming delocalized excitons. This imparts exciting photophysical properties such as extreme blue or red shifts (seen in H- or J-aggregates respectively)\, narrow linewidths and high molar absorptivities. We modulate the transition dipole couplings within an aggregate via molecular packing\, topology\, and disorder in order to tune and explore new photophysical behaviors. In this talk\, I will discuss the unusual situation that arises from 2D transition dipole coupling in sheet-like aggregates. In addition to traditional H- and J-aggregation\, we find a new case of ‘I-aggregation’ which shows intermediate characteristics of H- and J-aggregates. I will also describe how we use thermodynamics of self-assembly to control the aggregate packing and thereby\, tune excitonic properties. Using a three-component equilibrium model\, I will lay down general principles for selectively stabilizing H- or J-aggregates\, allowing us to construct a library of 2D J-aggregates with absorptions spanning the visible and shortwave infrared (SWIR) regions. Finally\, I will show how subtle differences in chromophore structures within this library modulate the aggregate packing and eventually lead to distinct excitonic band pictures\, that can be experimentally probed using temperature dependent spectroscopy. Overall\, this work establishes molecular aggregation as a tunable avenue for accessing unusual photophysical properties and thus\, opens up organic chromophores to new functionalities including SWIR imaging\, plexitonics\, and telecommunications.
URL:https://www.chemistry.ucla.edu/seminars/cancelled-chem-218-student-exit-seminar-arundhati-deshmukh/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210210T160000
DTEND;TZID=America/Los_Angeles:20210210T160000
DTSTAMP:20260615T141555
CREATED:20210106T205351Z
LAST-MODIFIED:20210106T205351Z
UID:13412-1612972800-1612972800@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Cunjiang Yu
DESCRIPTION:“Rubbery Electronics” \nAbstract: Seamlessly merging electronics with biology is of imminent importance in addressing grand societal challenges in health and joy of living. However\, the main challenge lies in the huge mechanical mismatch between the current form of rigid electronics and the soft nature of biology. This talk will present a new type of electronics\, namely “rubbery electronics”\, with tissue-like softness and stretchability\, which is constructed all based on elastic\, rubbery electronic materials. The hope is that rubbery electronics could ultimately solve the challenge in seamless integration between biology and electronics. The innovations in rubbery electronic materials and devices set the foundation for rubbery electronics and integrated system. The presentation will feature our recent results in rubbery semiconductors\, fully rubbery transistors\, logic gates\, integrated electronics\, sensors\, smart skins\, neurologically integrated function systems\, medical implants\, etc.
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-cunjiang-yu/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210209T160000
DTEND;TZID=America/Los_Angeles:20210209T160000
DTSTAMP:20260615T141555
CREATED:20210120T175055Z
LAST-MODIFIED:20210120T175055Z
UID:13432-1612886400-1612886400@www.chemistry.ucla.edu
SUMMARY:Small molecule inhibitors of 15-prostaglandin dehydrogenase promote tissue repair and regeneration
DESCRIPTION:Abstract: Prostaglandin E2 promotes tissue repair and regeneration in multiple tissues. Small molecule inhibitors of the PGE2-degrading enzyme\, 15-prostaglandin dehydrogenase\, could elevate PGE2 levels in vivo with applications in multiple disease contexts. We have discovered two chemical series of enzyme inhibitors. Medicinal chemistry efforts have led to sub-nM inhibitors with excellent bioavailability and physicochemical properties. Lead compounds demonstrate activity in mouse models of inflammatory bowel disease\, recovery from bone marrow transplantation\, and neurodegeneration.
URL:https://www.chemistry.ucla.edu/seminars/small-molecule-inhibitors-15-prostaglandin-dehydrogenase-promote-tissue-repair-and/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210209T130000
DTEND;TZID=America/Los_Angeles:20210209T130000
DTSTAMP:20260615T141555
CREATED:20210120T173300Z
LAST-MODIFIED:20210120T173300Z
UID:13431-1612875600-1612875600@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday\, February 9th\, 2021 at 1:00 PM.  We are pleased to invite all students\, postdocs\, faculty\, and staff.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-4/
CATEGORIES:Other,Seminars
END:VEVENT
END:VCALENDAR