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X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
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TZID:America/Los_Angeles
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TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
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TZOFFSETFROM:-0700
TZOFFSETTO:-0800
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DTSTART:20231105T090000
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230307T130000
DTEND;TZID=America/Los_Angeles:20230307T143000
DTSTAMP:20260613T085710
CREATED:20230105T002757Z
LAST-MODIFIED:20230208T013225Z
UID:27020-1678194000-1678199400@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series: Long Luo
DESCRIPTION:Flyer: Prof. Long Luo Flyer \nTitle: Rational Design of Alternating Current Electrolysis (ACE) for Organic Synthesis \nAbstract: In this presentation\, I will talk about the history of alternating current electrolysis (ACE) for organic synthesis and our recent work on exploring and quantitatively understanding the unique reactivity of ACE\, including mimicking the redox-neutral environment of photoredox catalysis\, controlling the one- or two-electron oxidation for selective amine functionalization\, and site-selective hydrogen isotope exchange reactions.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-for-integrated-catalysis-webinar-series-long-luo/
CATEGORIES:Inorganic Chemistry,Seminars
LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230306T160000
DTEND;TZID=America/Los_Angeles:20230306T170000
DTSTAMP:20260613T085710
CREATED:20221215T224709Z
LAST-MODIFIED:20230104T163905Z
UID:26941-1678118400-1678122000@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: Jagjit Nanda
DESCRIPTION:Prof Nanda Flyer \nTitle: Next Generation Solid-Electrolytes and Cathode Design for All Solid-State Batteries \nAbstract:   Lithium-metal based solid-state batteries (SSB) are considered to  the holy-grail of the  next generation battery technology for their promise of higher energy density (500 Wh/Kg)\, safety and providing a flexible platform for integrating a number of promising solid-electrolytes (SE) with  high capacity cathodes using either a thin lithium metal or anode free configuration. The design rule for achieving high energy and fast charge SSB will be discussed with specific focus on sulfide and halide based solid-electrolytes. Most of the sulfide-based SE compositions such as Li3PS4 and Argyrodite (LiPS5X; X= Cl\, Br) are thermodynamically unstable against high voltage cathodes such as NMC and hence are not best catholyte for solid-state cathodes. On the contrary\, halide SEs have higher oxidative stability but poor stability with respect to Li-metal. The talk will also cover development of thin SE membranes (50 micron) for integration with cathodes and development of Na-ion based SE. \n 
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-jagjit-nanda/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230303T153000
DTEND;TZID=America/Los_Angeles:20230303T163000
DTSTAMP:20260613T085710
CREATED:20221214T004231Z
LAST-MODIFIED:20230301T211839Z
UID:26858-1677857400-1677861000@www.chemistry.ucla.edu
SUMMARY:Biochemistry Seminar Series - Prof. Shana V. Stoddard
DESCRIPTION:Shana Stoddard Flyer \nTitle: Molecular Recognition: The Keys to Design of Biotools \nAbstract: My lab\, the “Molecular Immunotherapeutics Research” (MIR) lab studies systems which are involved in cancers\, neurological disorders\, coronaviruses\, and autoimmune diseases. Utilizing both computational and experimental methodologies work in the MIR lab explores the basic molecular details of structure and design and its implications on the development of biotools and therapeutics. Current work in the MIR lab involves investigation of structure/function relationships in the thrombospondin repeat (TSR) domain containing super family of proteins known to be heavily involved in binding interactions in the extracellular matrix (ECM) promoting functions such as angiogenesis\, cell migration\, and tissue remodeling. Development of both three-dimensional protein homology models and biotools to selectively target the TSR domains would advance our ability to evaluate both structure function relationships and how these proteins participate in molecular interactions that influence ECM organization. A second project the MIR lab is pursuing is development of optimization guidelines for drug development antiviral targeting coronaviruses. This talk will detail key findings that may contribute to the study of the TSR domain containing super family of proteins\, design of biotools to target TSR domains to further study of ECM reorganization and the development of both small molecule and protein based therapeutic options for coronavirus antivirals. The advancements discussed will highlight new directions for understanding ECM reorganization and binding partner interactions\, and key structural parameters for development of high affinity drug candidates for COVID-19 antiviral treatments
URL:https://www.chemistry.ucla.edu/seminars/biochemistry-seminar-series-prof-shana-v-stoddard/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230302T120000
DTEND;TZID=America/Los_Angeles:20230302T130000
DTSTAMP:20260613T085710
CREATED:20230223T223008Z
LAST-MODIFIED:20230223T223008Z
UID:28420-1677758400-1677762000@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Shreya Patel
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/events/chem-218-student-exit-seminar-shreya-patel/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Chem 218 Student Exit Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230301T160000
DTEND;TZID=America/Los_Angeles:20230301T173000
DTSTAMP:20260613T085710
CREATED:20221214T005258Z
LAST-MODIFIED:20230221T230656Z
UID:26866-1677686400-1677691800@www.chemistry.ucla.edu
SUMMARY:Jeffrey I. Zink Inorganic Chemistry Seminar Series: Tatiana Bronich
DESCRIPTION:Flyer: Prof. Tatiana Bronich Flyer \nMeet the Speaker: 11 a.m.\, YH 3096 \nTitle: Amphiphilic copolymers mediated therapeutics in cancer \nAbstract: Amphiphilic block copolymers\, in particular self-assembled block copolymer micelles\, have been utilized in pharmaceutics for development of novel therapeutic and diagnostic modalities. Advantages of the polymeric micelles include their small size\, long circulation in bloodstream\, ability to circumvent renal excretion and extravasation at sites of enhanced vascular permeability. They can be designed to facilitate the incorporation of a variety of compounds or even particles through a combination of electrostatic\, hydrophobic\, and hydrogen bonding interactions. Combining drugs cargos with synergistic activities in a single polymer micelle emerged as an attractive strategy for the development of cancer treatment modalities with enhanced therapeutic efficacy and reduced adverse side effects. We have adopted a polypeptide-based polymer platform as the biodegradable construction material for design of micellar nanocarriers for combination therapy in cancer.
URL:https://www.chemistry.ucla.edu/seminars/jeffrey-i-zink-inorganic-chemistry-seminar-series-tatiana-bronich/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Inorganic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230227T160000
DTEND;TZID=America/Los_Angeles:20230227T170000
DTSTAMP:20260613T085710
CREATED:20221215T224357Z
LAST-MODIFIED:20230104T164621Z
UID:26939-1677513600-1677517200@www.chemistry.ucla.edu
SUMMARY:Knobler Lecture: Vinothan Manoharan
DESCRIPTION:Prof Manoharan Knobler Lecture Flyer \nTitle: The Self-Assembly of Simple RNA Viruses \nAbstract: Self-assembly is the process by which molecules or particles spontaneously form ordered structures\, driven by interactions and thermal fluctuations. The term “self-assembly” was originally coined to describe the formation of simple RNA viruses\, which consist of RNA and coat proteins that form an icosahedral shell (called a capsid) that protects the RNA. Some of these viruses can be assembled in vitro\, in the absence of any host cell factors. This result suggests that we can understand RNA virus self-assembly from the perspective of statistical mechanics. The central question is how a random process like self-assembly can lead to a high yield of well-formed viruses. I will discuss some potential answers to that question based on experiments that measure the kinetics of assembly of individual viruses — experiments that began as a result of a collaboration with UCLA.
URL:https://www.chemistry.ucla.edu/events/knobler-lecture-vinothan-manoharan/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Knobler
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230227T150000
DTEND;TZID=America/Los_Angeles:20230227T155000
DTSTAMP:20260613T085710
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T214355Z
UID:24065-1677510000-1677513000@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Jacqueline Bustamante
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-02-27/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230224T153000
DTEND;TZID=America/Los_Angeles:20230224T163000
DTSTAMP:20260613T085710
CREATED:20221214T004131Z
LAST-MODIFIED:20230222T233234Z
UID:26856-1677252600-1677256200@www.chemistry.ucla.edu
SUMMARY:Biochemistry Seminar Series - Prof. Lillian Fritz-Laylin
DESCRIPTION:Lillian Fritz-Laylin Flyer \nTitle: The evolution and specification of the cytoskeletal networks \nAbstract: Cells physically manipulate their environments; swimming through liquids\, crawling across surfaces\, and actively ingesting objects large and small. Inside eukaryotic cells lies a seething mass of cytoplasm through which thousands of different objects are pushed and pulled to specific cellular locations. These and other dynamic processes are controlled by polymer systems called the cytoskeleton. The two most common cytoskeletal polymers—actin and microtubules—evolved over a billion years ago and are still used today by animals\, plants\, and their unicellular relatives. Although the proteins that comprise actin and microtubule polymers themselves are surprisingly similar across species\, the hundreds of different proteins that regulate their dynamics are wildly variable\, contributing to aspects of organismal diversity critical to human health and agriculture. My laboratory combines cell biology\, comparative genomics\, and phylogenetics to understand the evolution\, diversification\, and regulation of actin and microtubule networks. This research program harnesses the burgeoning wealth of fully sequenced genomes and molecular tool development to (1) identify the molecular mechanisms that specify distinct cytoskeletal functions\, and (2) determine how and when the cytoskeleton changed during evolution.
URL:https://www.chemistry.ucla.edu/seminars/biochemistry-seminar-series-prof-lillian-fritz-laylin/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230223T160000
DTEND;TZID=America/Los_Angeles:20230223T170000
DTSTAMP:20260613T085710
CREATED:20230207T211913Z
LAST-MODIFIED:20230207T211913Z
UID:28073-1677168000-1677171600@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Emily Balskus
DESCRIPTION:Balskus Flyer\n\nTitle: Deciphering the Human Microbiome with Chemistry\n\n\n\n\n\n\n\n\n\n\n\n\n\nAbstract: The human body is colonized by trillions of microorganisms that exert a profound influence on human biology\, in part by providing functional capabilities that extend beyond those of host cells. In particular\, there is growing evidence linking chemical processes carried out by the human gut microbiome to diseases such as colorectal cancer. However\, we still do not understand the vast majority of the molecular mechanisms underlying this phenomenon. Major obstacles faced in surmounting this knowledge gap include the difficulty linking functions associated with the human gut microbiota to specific microbial enzymes and the challenge of controlling these activities in complex microbial communities. This talk will discuss my lab’s efforts to characterize gut microbial metabolic activities that are linked to colorectal cancer\, including a gut microbial genotoxin called colibactin. Gaining a molecular understanding of cancer-associated gut microbial activities will not only help to elucidate the mechanisms by which these organisms contribute to carcinogenesis but should also enable efforts to treat and prevent disease by manipulating this microbial community.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-emily-balskus/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230223T120000
DTEND;TZID=America/Los_Angeles:20230223T130000
DTSTAMP:20260613T085710
CREATED:20230120T212342Z
LAST-MODIFIED:20230120T212342Z
UID:27373-1677153600-1677157200@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Anthony Sica
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/events/chem-218-student-exit-seminar-anthony-sica/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230223T110000
DTEND;TZID=America/Los_Angeles:20230223T120000
DTSTAMP:20260613T085710
CREATED:20221215T223825Z
LAST-MODIFIED:20230202T192222Z
UID:26935-1677150000-1677153600@www.chemistry.ucla.edu
SUMMARY:Special Physical Chemistry Seminar 228: Jörg Enderlein
DESCRIPTION:Enderlein Flyer Updated \nTitle: Metal and Graphene Induced Energy Transfer \nAbstract:   Metal-Induced Energy Transfer (MIET) Imaging is a recently developed method [1] that allows for nanometer resolution along the optical axis. It is based on the fact that\, when placing a fluorescent molecule close to a metal\, its fluorescence properties change dramatically\, due to electromagnetic coupling of its excited state to surface plasmons in the metal. This is very similar to Förster Resonance Energy Transfer (FRET) where the fluorescence properties of a donor are changed by the proximity of an acceptor that can resonantly absorb energy emitted by the donor. In particular\, one observes a strongly modified lifetime of its excited state. This coupling between an excited emitter and a metal film is strongly dependent on the emitter’s distance from the metal. We have used this effect for mapping the basal membrane of live cells with an axial accuracy of ~3 nm. The method is easy to implement and does not require any change to a conventional fluorescence lifetime microscope; it can be applied to any biological system of interest\, and is compatible with most other super-resolution microscopy techniques that enhance the lateral resolution of imaging [2-4]. Moreover\, it is even applicable to localizing individual molecules [5-6]\, thus offering the prospect of three-dimensional single-molecule localization microscopy with nanometer isotropic resolution for structural biology [7]. I will also present latest developments of MIET where we use a single layer of graphene instead of a metal film that allows for increasing the spatial resolution down to a few Ångströms [8-10].
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-jorg-enderlein/
LOCATION:Young Hall 2033
CATEGORIES:Physical Chemistry Seminar,Special Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230222T160000
DTEND;TZID=America/Los_Angeles:20230222T173000
DTSTAMP:20260613T085710
CREATED:20221214T004910Z
LAST-MODIFIED:20230112T191517Z
UID:26864-1677081600-1677087000@www.chemistry.ucla.edu
SUMMARY:Jeffrey I. Zink Inorganic Chemistry Seminar Series: Seth Cohen
DESCRIPTION:Flyer: Prof. Seth Cohen Flyer \nTitle: Exploring MOF-Polymer Hybrid Materials \nAbstract: Hybrid materials of metal-organic frameworks (MOFs) and polymers have gained interest as processible composites that might be suitable for a wide range of applications. A number of approaches have been pursued to create MOF-polymer composites\, including mixed-matrix membranes (MMMs) prepared with MOFs\, polymer-decorated MOF particles\, and MOFs constructed from polymer buidling blocks referred to as polyMOFs. The design\, synthesis\, and unusual properties of these MOF-polymer composite materials will be presented and discussed.
URL:https://www.chemistry.ucla.edu/seminars/jeffrey-i-zink-inorganic-chemistry-seminar-series-seth-cohen/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Inorganic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230217T153000
DTEND;TZID=America/Los_Angeles:20230217T163000
DTSTAMP:20260613T085710
CREATED:20221214T004004Z
LAST-MODIFIED:20230215T004852Z
UID:26854-1676647800-1676651400@www.chemistry.ucla.edu
SUMMARY:Biochemistry Seminar Series - Prof. Jonathan Abraham
DESCRIPTION:Title: Mechanisms of immune evasion by the SARS-CoV-2 spike protein \nJonathan Abraham Flyer
URL:https://www.chemistry.ucla.edu/seminars/biochemistry-seminar-series-prof-jonathan-abraham/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230216T160000
DTEND;TZID=America/Los_Angeles:20230216T170000
DTSTAMP:20260613T085710
CREATED:20221201T194032Z
LAST-MODIFIED:20221201T194032Z
UID:26558-1676563200-1676566800@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Wei Liu
DESCRIPTION:Prof Liu Flyer \nCopper-Catalyzed Coupling Reactions: Mechanism\, Catalysis\, and Applications in Life Sciences  \nAbstract: Owing to their many attractive characteristics\, copper catalysts represent appealing alternatives to precious metal catalysts\, although various limitations remain in copper-catalyzed cross-coupling reactions. Recently\, we and others recognized that copper catalysis presents a powerful strategy to functionalize sp3 hybridized carbon radicals for the construction of carbon-carbon and carbon-heteroatom bonds. In this talk\, I will discuss our group’s recent efforts in understanding the mechanism of copper catalysis and developing new copper-catalyzed cross-coupling reactions.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-wei-liu/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230216T120000
DTEND;TZID=America/Los_Angeles:20230216T130000
DTSTAMP:20260613T085710
CREATED:20230120T212113Z
LAST-MODIFIED:20230120T212113Z
UID:27341-1676548800-1676552400@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Ashley Shin
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/events/chem-218-student-exit-seminar-ashley-shin/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230213T160000
DTEND;TZID=America/Los_Angeles:20230213T170000
DTSTAMP:20260613T085710
CREATED:20221215T223223Z
LAST-MODIFIED:20230104T163501Z
UID:26933-1676304000-1676307600@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: Anton Van der Ven
DESCRIPTION:Prof Van der Ven Flyer \nTitle: From Electronic Structure to Battery Thermodynamics and Kinetics \nAbstract:   Most electrochemical processes can be modeled with powerful phenomenological theories that describe ion transport\, interface reactions and mechanical responses. Phenomenological descriptions\, however\, rely on materials specific coefficients and free energies\, which are quantities that are often difficult to measure in isolation. An alternative to an experimental approach is to predict these quantities from first principles. Since electrochemical processes are thermally activated\, temperature and entropy play an important role. The prediction of materials properties\, therefore\, requires a statistical mechanics approach. In this talk I will describe a generalized framework with which to connect the electronic structure of crystalline solids to their equilibrium and kinetic properties at the macroscopic scale. I will illustrate how the application of first-principles statistical mechanics can generate crucial ingredients for phenomenological models of electrochemical processes\, including composition dependent free energies and open circuit voltage profiles\, ionic transport coefficients and chemo-mechanical response functions. The capability to predict thermodynamic and kinetic properties of electrode materials is allowing us to explore and design new battery chemistries and concepts. Electrode materials for Li\, Na and Mg ion batteries undergo a series of phase transformations as a result of large changes in concentration during each charge and discharge cycle. While the mechanisms of these phase transformations remain poorly characterized\, they can to an extent be understood with first-principles multi-scale approaches.
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-anton-van-der-ven/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230213T150000
DTEND;TZID=America/Los_Angeles:20230213T155000
DTSTAMP:20260613T085710
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213949Z
UID:24063-1676300400-1676303400@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Brady Dehnert
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-02-13/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230210T153000
DTEND;TZID=America/Los_Angeles:20230210T163000
DTSTAMP:20260613T085710
CREATED:20221214T003905Z
LAST-MODIFIED:20230203T160658Z
UID:26852-1676043000-1676046600@www.chemistry.ucla.edu
SUMMARY:Biochemistry Seminar Series - Prof. Linlin Zhao
DESCRIPTION:Title: Exploiting Abasic Site Chemistry to Decipher Mitochondrial Genome Biology \nAbstract: Human mitochondrial DNA (mtDNA) encodes 37 essential genes and plays a critical role in mitochondrial and cellular functions. Compared to nuclear DNA (nDNA)\, mtDNA is more susceptible to chemical modifications by endogenous and exogenous factors partly due to its proximity to the oxidative phosphorylation system and the lack of certain DNA repair pathways. Our research aims to understand the chemical and molecular mechanisms by which DNA modifications are processed in the mitochondrial genome and their implications in human diseases. In this seminar\, I will discuss our recent efforts to probe the role of mitochondrial transcription factor A (TFAM) in damaged mtDNA degradation. We focus on a prevalent type of DNA modification\, i.e.\, abasic (AP) sites\, formed by the loss of nucleobases during natural depurination or depyrimidination and DNA repair. We used biochemical and cellular assays to demonstrate that TFAM accelerates DNA scission at AP sites. The reaction produces chemically reactive entities at the DNA terminus and leads to secondary products\, such as TFAM-DNA cross-links and glutathionylated DNA single-strand breaks\, which could serve as triggers for mtDNA degradation and the recruitment of additional proteins. We have also identified the cross-linking amino acids of TFAM using mass spectrometry. Together\, our research demonstrates the involvement of TFAM in processing AP DNA damage in mitochondria. Last but not least\, I will discuss how we exploit the chemistry of AP sites to develop specific chemical probes to label and enrich AP-DNA. We have successfully used the workflow to map AP sites and DNA alkylation modifications using next-generation sequencing in cultured human cells. \nLinlin Zhao Flyer
URL:https://www.chemistry.ucla.edu/seminars/biochemistry-seminar-series-prof-linlin-zhao/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230209T160000
DTEND;TZID=America/Los_Angeles:20230209T170000
DTSTAMP:20260613T085710
CREATED:20221201T192531Z
LAST-MODIFIED:20221201T192715Z
UID:26554-1675958400-1675962000@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Nicholas Ball
DESCRIPTION:Prof Ball Flyer \nUnlocking Fluorine: Activation of Sulfur(VI) Fluorides for New Sulfur-Fluorine Exchange (SuFEx) Reactions \nAbstract: Sulfur-fluoride exchange (SuFEx) chemistry is emerging as a promising synthetic tool in chemical biology\, material science\, and synthetic chemistry. In synthesis\, sulfur (VI) fluorides show unique promise as synthons in organic chemistry due their stability versus other sulfur (VI) halogen analogues. Key to the adoption of SuFEx chemistry is the development of efficient modes to synthesize and react sulfur (VI) fluorides. Research initiatives employing group 2\, and transition-metal chemistry toward the synthesis of sulfonyl fluorides will be described. New SuFEx methods that react a broad set of S (VI) fluorides with carbon\, oxygen\, and nitrogen-based nucleophiles towards structurally diverse S(VI) compounds will also be presented. \nA focus will be on a new SuFEx reaction to synthesize nitrogen-based sulfonylated compounds from a variety of S(VI) fluorides mediated via a Lewis acidic calcium salt will be described. Under a unified set of reaction conditions\, sulfonyl fluorides\, fluorosulfates\, and sulfamoyl fluorides can be coupled with a variety of amines to synthesis a wide array of aryl and alkyl sulfonamides\, sulfamides\, and sulfamates in good to excellent yield. Computational and NMR kinetic studies that aim to elucidate the mechanism of Ca-activation will be discussed. Lessons learned from the mechanistic studies have led to preliminary data suggesting Ca-catalysis is possible.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-nicholas-ball/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230207T130000
DTEND;TZID=America/Los_Angeles:20230207T143000
DTSTAMP:20260613T085710
CREATED:20221220T231700Z
LAST-MODIFIED:20221220T231700Z
UID:26968-1675774800-1675780200@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series: Frank A. Leibfarth
DESCRIPTION:Title: Stereoselective Cationic Polymerization of Prochiral Monomers \nAbstract: The stereochemistry of vinyl polymers\, known as polymer tacticity\, is intimately linked to their resultant material properties. Despite the well-developed stereoselective methods for the polymerization of propylene and other nonpolar -olefins\, general approaches to the stereoselective polymerization of polar vinyl monomers are not well developed. In this lecture\, we will discuss the design of chiral counterions that systematically tune the reactivity and chain-end stereochemical environment during cationic polymerization. This approach overrides conventional chain-end stereochemical bias to achieve catalyst-controlled stereoselective polymerization of prochiral vinyl monomers through a cationic mechanism. We demonstrate that chiral counterion catalysis is a general conceptual approach that can be leveraged for the stereoselective polymerization of both vinyl ethers and N-vinyl carbazoles. The properties of the isotactic polymers will also be described\, with a focus on how unique function can be derived from stereocontrol.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-for-integrated-catalysis-webinar-series-frank-a-leibfarth/
CATEGORIES:Other,Seminars
LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230206T160000
DTEND;TZID=America/Los_Angeles:20230206T170000
DTSTAMP:20260613T085710
CREATED:20221215T194904Z
LAST-MODIFIED:20230104T163131Z
UID:26916-1675699200-1675702800@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: David Ginger
DESCRIPTION:Prof Ginger Flyer \nTitle: Probing Ion Injection and Transport in Conjugated Polymers: From Bioelectronic Brains to Energy Storage \nAbstract:   Ion injection and transport in conjugated polymers affects the performance of devices ranging from organic electrochemical transistors (OECT) for bioelectronic signal transduction\, and from aqueous polymer batteries to next generation neuromorphic computing architectures. The performance of conjugated polymers in these applications is due to the ability of the polymer to accommodate ionic countercharge throughout the device volume during redox processes.  For instance\, in OECTs\, the resulting volumetric capacitance allows for very large modulations of the charge density in the transistor channel and large transconductance values. Using OECTs as a testbed\, we explore measurements on different polymers with different counterions. At the nanoscale\, we use electrochemical strain microscopy (ESM) to probe local swelling resulting from ion uptake\, and photoinduced force microscopy (PiFM) to probe the IR fingerprints of ion injection which we correlate with ensemble measurements such as electrochemical quartz crystal microbalance (eQCM)\, spectroelectrochemistry\, and in operando synchrotron structure measurements.  We correlate these methods to gain insight into how local polymer structure governs ion uptake and transport and how the chemical nature of the counterion and associated structural changes impact electronic charge transport.  We show that the counterion polarizability strongly affects both ion injection kinetics\, as well as the mechanism of charge compensation (contrasting counterion expulsion vs. and counterion injection). In the process we observe non-Fickian ion “diffusion” in a conjugated polymer which show can be explained as a propagating phase change front. We discuss microscopic insights into these processes and propose new material design rules.
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-david-ginger/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230206T150000
DTEND;TZID=America/Los_Angeles:20230206T155000
DTSTAMP:20260613T085710
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213858Z
UID:24062-1675695600-1675698600@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Daniel Min
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-02-06/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230206T130000
DTEND;TZID=America/Los_Angeles:20230206T140000
DTSTAMP:20260613T085710
CREATED:20221215T225346Z
LAST-MODIFIED:20230130T193112Z
UID:26945-1675688400-1675692000@www.chemistry.ucla.edu
SUMMARY:Norma Stoddart Prize - Marco Messina
DESCRIPTION:Title: Tandem Activity-Based and Labeling Approaches to Monitor Transient Analytes in Biological Systems \nNorma Stoddart Prize Flyer – Dr. Marco Messina
URL:https://www.chemistry.ucla.edu/events/norma-stoddart-prize-marco-messina/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Norma Stoddart
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230206T100000
DTEND;TZID=America/Los_Angeles:20230206T230000
DTSTAMP:20260613T085710
CREATED:20230130T193947Z
LAST-MODIFIED:20230130T194037Z
UID:27942-1675677600-1675724400@www.chemistry.ucla.edu
SUMMARY:Norma Stoddart Prize - Around the World in 80 Years by Sir Fraser Stoddart
DESCRIPTION:10:00 – 11:00 AM \nAround the World in 80 Years\, a presentation by Sir Fraser Stoddart \nNorma Stoddart Prize Flyer – Dr. Marco Messina
URL:https://www.chemistry.ucla.edu/events/norma-stoddart-prize-around-the-world-in-80-years-by-sir-fraser-stoddart/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Norma Stoddart
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230206T090000
DTEND;TZID=America/Los_Angeles:20230206T100000
DTSTAMP:20260613T085710
CREATED:20230130T193501Z
LAST-MODIFIED:20230130T194133Z
UID:27940-1675674000-1675677600@www.chemistry.ucla.edu
SUMMARY:Norma Stoddart Prize - Grad Student Q&A with Sir Fraser Stoddart
DESCRIPTION:9:00 AM – 10:00 AM \nGrad Student Q&A with Nobel Laureate Sir Fraser Stoddart \nNorma Stoddart Prize Flyer – Dr. Marco Messina
URL:https://www.chemistry.ucla.edu/events/norma-stoddart-prize-grad-student-qa-with-sir-fraser-stoddart/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Norma Stoddart
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230203T153000
DTEND;TZID=America/Los_Angeles:20230203T163000
DTSTAMP:20260613T085710
CREATED:20221214T003714Z
LAST-MODIFIED:20230127T212037Z
UID:26850-1675438200-1675441800@www.chemistry.ucla.edu
SUMMARY:Biochemistry Seminar Series - Prof. Zhipeng Lu
DESCRIPTION:Flyer: Zhipeng Lu Flyer \nTitle: What does RNA look like in cells? Structures\, interactions and modifications. \nAbstract: RNA in living cells are in constant motion\, form dynamic structures\, and interact with many molecules\, including other RNAs. Direct determination of RNA structures and interactions in vivo is essential to understanding their functions\, and developing new RNA-based and RNA-targeting therapeutics\, but has been challenging in the past. We developed a number of novel chemical and computational tools to capture the 2D and 3D RNA structurome and interactome in cells\, providing a comprehensive view of RNA conformations that underlie their roles in gene regulation and human diseases. In particular\, our recent applications of these methods revealed new mechanisms in lncRNA functions and RNA modifications.
URL:https://www.chemistry.ucla.edu/seminars/biochemistry-seminar-series-prof-zhipeng-lu/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230202T160000
DTEND;TZID=America/Los_Angeles:20230202T170000
DTSTAMP:20260613T085710
CREATED:20221201T185038Z
LAST-MODIFIED:20221201T185038Z
UID:26550-1675353600-1675357200@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Zachary Wickens
DESCRIPTION:Prof. Wickens Flyer \nSelective Synthesis via Light and Electricity \nAbstract: We are investigating how organic radical ions–typically thought of as fleeting intermediates–can be tamed and exploited as a new family of organocatalysts and small molecule reagents. We identified selective generation of such species as a key hurdle stymying exploration these electronically-destabilized systems. To address this problem\, we have leveraged electrochemistry to develop new synthetic transformations driven by organic radical ions. Electrochemistry offers not only an environmentally benign approach to promote redox events but also substantially simplifies the study of these unusual systems by enabling the exclusion of byproducts from oxidation or reductive generation of the key radical ion promoters. \nThis seminar will describe two new platforms for synthetic reaction development based on electrogenerated persistent organic radical ions. In the first system\, we describe the development of a new family of radical anion photoredox catalysts over a volt more reducing than conventional photocatalyst systems. These potent catalysts have enabled abundant but classes of arene substrates to now act as general aryl radical precursors for diverse radical coupling reactions. In the second system\, we will discuss a new approach to oxidatively functionalize alkenes via a metastable dielectrophilic intermediate derived from reaction with thianthrene radical cation. This strategy has enabled new synthetic methods to construct high value aliphatic amine products by coupling amines and feedstock hydrocarbons.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-zachary-wickens/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230131T160000
DTEND;TZID=America/Los_Angeles:20230131T170000
DTSTAMP:20260613T085710
CREATED:20230107T033823Z
LAST-MODIFIED:20230123T183303Z
UID:27096-1675180800-1675184400@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Soumitra Athavale
DESCRIPTION:Tales in Molecular Evolution:  From Chiral Symmetry Breaking to New-to-Nature Biocatalysis \n\nThe evolutionary journey of chemistry on our planet\, from small molecules to genetic polymers\, presents fascinating opportunities for the organic chemist. At one end\, mysterious early steps evoke grand questions at the foundations of chemistry\, while at the other\, biology’s extraordinary machinery lies primed for creative manipulation.   \nAn illustration of the former is the riddle of the origin of biological homochirality\, inspiring the general query\, ‘can asymmetric synthesis transpire without any chiral intervention’? The Soai reaction – diisopropylzinc alkylation of pyrimidine carbaldehydes – remains a singular\, celebrated example where this is possible and has received widespread attention from diverse chemical fields. I will present structural\, experimental\, and computational investigations which reveal the first comprehensive mechanistic picture of this iconic transformation.  \nFor the latter case\, I will showcase how the principles of directed evolution can be applied to develop new enzymes for promoting processes never seen in nature. The engineering of heme proteins enables enantioselective catalysis of challenging nitrene C–H insertion reactions for accessing nitrogen containing compounds from feedstock chemicals. This example of ‘new-to-nature biocatalysis’ is emblematic of a modern age of protein biochemistry that promises to revolutionize the use of enzymes for molecular construction.  
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-soumitra-athavale/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230130T160000
DTEND;TZID=America/Los_Angeles:20230130T170000
DTSTAMP:20260613T085710
CREATED:20230113T213541Z
LAST-MODIFIED:20230113T213541Z
UID:27153-1675094400-1675098000@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: Dolores Bozovic
DESCRIPTION:Prof. Bozovic Flyer \nTitle: Physics of the Auditory System \nAbstract: Hair cells of the auditory system constitute a remarkable biological sensor that exhibits nanometer-scale sensitivity of mechanical detection. Our experiments explore the active nonlinear processes behind the detection of very weak signals. We demonstrate the presence of chaos in the innate motility of active bundles\, and explore both theoretically and experimentally its role in enhancing the sensitivity of detection. We further show that these cells utilize weakly chaotic dynamics to combine sensitive response with high temporal resolution. The presence of chaos in individual hair bundles also aids in the synchronization between coupled hair cells\, and gives rise to new dynamical states. Finally\, we explore the neural mechanisms that reduce and control the responsiveness of the cell. Specifically\, we show that the efferent neurons serve as a gain control system\, which can strongly affect the very compliance of the mechanosensory cells. \n 
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-dolores-bozovic/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230130T150000
DTEND;TZID=America/Los_Angeles:20230130T155000
DTSTAMP:20260613T085710
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213627Z
UID:24061-1675090800-1675093800@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Georgia Scherer
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-01-30/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
END:VCALENDAR