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X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
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TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
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DTSTART:20210314T100000
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DTSTART:20211107T090000
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210420T160000
DTEND;TZID=America/Los_Angeles:20210420T160000
DTSTAMP:20260615T125014
CREATED:20210329T175126Z
LAST-MODIFIED:20210329T175126Z
UID:13475-1618934400-1618934400@www.chemistry.ucla.edu
SUMMARY:Trehalose glycopolymer as an excipient for insulin stabilization: safety\, mechanism\, optimization\, and fluid properties
DESCRIPTION:Abstract: Biopharmaceutics are widely used to treat serious diseases\, but the architectural and chemical complexity that makes proteins good therapeutics renders them susceptible to degradation and aggregation during manufacturing\, transportation\, and storage. Loss of intact biopharmaceutics causes patient under-dosing as well as adverse reactions. With the growth of biopharmaceuticals coming to market\, the need increases for benign excipients to stabilize proteins against environmental stresses without posing a safety concern. A class of glycopolymers bearing a pendant trehalose\, a natural sugar\, were developed by our group and demonstrated the ability to stabilize a range of biopharmaceuticals. However\, this research area had not yet explored the trehalose polymer for safety\, mechanism of stabilization\, physical properties\, or potential optimization. This talk focuses on the ongoing efforts to expand our knowledge base in applying the methacrylate trehalose polymer as an excipient to formulate biopharmaceuticals. In particular\, I will highlight the glycopolymer’s benign immunogenic\, excretion\, and biodistribution behaviors as well as how proteins are unaffected in vivo by the polymer. Next\, because the mechanism by which proteins are stabilized as well as the conformation in which they are stabilized affects their onset of activity\, I will show how the glycopolymer stabilizes insulin. Due to the importance of patient comfort and compliance\, I will finally present my research into the fluid properties of the glycopolymer\, optimization of insulin formulations\, and optimized formulations properties. Altogether\, this work shows specifically how insulin is stabilized by the methacrylate trehalose polymer and\, more broadly\, that the glycopolymer can be broadly applied as an excipient to stabilize therapeutic macromolecules safely and without significantly changing the in vivo response or physical properties.
URL:https://www.chemistry.ucla.edu/seminars/trehalose-glycopolymer-excipient-insulin-stabilization-safety-mechanism-optimization-and/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210419T160000
DTEND;TZID=America/Los_Angeles:20210419T160000
DTSTAMP:20260615T125014
CREATED:20210323T204216Z
LAST-MODIFIED:20210323T204216Z
UID:13452-1618848000-1618848000@www.chemistry.ucla.edu
SUMMARY:Chem 228: Prof. Hirofumi Tanaka
DESCRIPTION:“Reservoir computing device composed by chemical dynamics”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-prof-hirofumi-tanaka/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210416T153000
DTEND;TZID=America/Los_Angeles:20210416T153000
DTSTAMP:20260615T125014
CREATED:20210325T211113Z
LAST-MODIFIED:20210325T211113Z
UID:13468-1618587000-1618587000@www.chemistry.ucla.edu
SUMMARY:Chem 268: Dylan Valencia
DESCRIPTION:Quinlan Group \n“Biochemical Characterization of Mammalian Formin FHOD3 in Cardiomyocytes”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-dylan-valencia/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210415T120000
DTEND;TZID=America/Los_Angeles:20210415T120000
DTSTAMP:20260615T125014
CREATED:20210408T223431Z
LAST-MODIFIED:20210408T223431Z
UID:13488-1618488000-1618488000@www.chemistry.ucla.edu
SUMMARY:Electrophotocatalysis with a trisaminocyclopropenium ion
DESCRIPTION:Abstract: This lecture will describe some recent developments in the area of electrophotocatalysis\, with a particular focus on a trisaminocyclopropenium (TAC) ion catalyst developed by our group.
URL:https://www.chemistry.ucla.edu/seminars/electrophotocatalysis-trisaminocyclopropenium-ion/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210415T100000
DTEND;TZID=America/Los_Angeles:20210415T100000
DTSTAMP:20260615T125014
CREATED:20210331T001119Z
LAST-MODIFIED:20220410T011049Z
UID:12320-1618480800-1618480800@www.chemistry.ucla.edu
SUMMARY:2020-2021 Sigman Symposium
DESCRIPTION:The UCLA Molecular Biology Institute (MBI) will hold the 2020-2021 Sigman Symposium in honor of Professor David Sigman (1939-2001)\, who was an internationally renowned UCLA professor of chemistry and biological chemistry who illuminated the molecular mechanisms by which enzymes catalyze biological reactions and was one of the founding members of the MBI. \n2020-2021 Sigman Award Honoree: \nProfessor Catherine DrennanDepartments of Chemistry and BiologyMassachusetts Institute of Technology andthe Howard Hughes Medical Institute \nKenote Address: “Shake\, Rattle\, & Roll:Capturing Snapshots of Ribonucleotide Reductase in Action” \nSymposium Schedule – Thursday\, April 15\, 2021 – 10 am to 1:30 pm \n\nTribute to David Sigman: Prof. Steven Clarke\nGuest Speaker: Prof. Douglas Rees (Caltech):“The Ns and Outs of Nitrogen Fixation”\nKeynote introduction/award presentation: Prof. Keriann Backus\nKeynote address: Prof. Catherine Drennan\nPoster Session and Poster Prize Announcement\n\nPosteSession: The poster session will feature immersion in an 8-bit world complete with “walking” around to interact with poster presenters and attendees\, games\, and more while providing an opportunity to share your science with our awardee\, members of the UCLA community\, and have a chance to win one of our poster prizes! Poster prizes will include Best Poster Prizes (up to four $250 prizes) and Honorable mention prizes (up to four $100 prizes) and will be selected with an audience voting component. All UCLA students and postdocs studying in any area of biology or chemistry are eligible to submit. To present a poster please fill out the google form with your poster title by Friday\, April 2\, 2021 and submit a png\, jpeg\, or gif image file of your poster to SigmanSymposium2021@gmail.com  by Tuesday April 6\, 2021. Poster prize winners will be announced after the poster session in a gather.town award ceremony.    \nFor more information about the Sigman Symposium or poster session please visit the MBI website or email SigmanSymposium2021@gmail.com. 
URL:https://www.chemistry.ucla.edu/seminars/2020-2021-sigman-symposium/
ATTACH;FMTTYPE=image/jpeg:https://www.chemistry.ucla.edu/wp-content/uploads/2021/03/drennan-400x400-2_0.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210413T160000
DTEND;TZID=America/Los_Angeles:20210413T160000
DTSTAMP:20260615T125014
CREATED:20210329T174856Z
LAST-MODIFIED:20210329T174856Z
UID:13474-1618329600-1618329600@www.chemistry.ucla.edu
SUMMARY:Perfluorocarbon nanomaterials as theranostic delivery vehicles
DESCRIPTION:Abstract: Perfluorocarbon nanoemulsions\, droplets of fluorous solvent stabilized by a polymeric amphiphile dispersed in water\, are an intriguing platform for drug delivery. The fluorous phase is biocompatible\, has a high dissolved oxygen content\, and is both lipophobic and hydrophobic\, preventing the leaching of payloads. Here\, we describe the use of perfluorocarbon nanoemulsions as a drug delivery platform in which the payload can be easily modified. First\, we utilize the high oxygen solubility of perfluorocarbons to perform photodynamic therapy\, a treatment modality that requires oxygen\, photosensitizer\, and light to produce cytotoxic reactive oxygen species. Next\, we deliver pDNA solubilized by noncovalent fluorous tags\, resulting in the transfection of cells. Lastly\, a panel of polymeric amphiphiles were studied to determine design properties such as size\, stability\, payload release\, cellular uptake and protein corona. With these design principles PFC nanoemulsions can be tailored to a desired application.
URL:https://www.chemistry.ucla.edu/seminars/perfluorocarbon-nanomaterials-theranostic-delivery-vehicles/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210413T130000
DTEND;TZID=America/Los_Angeles:20210413T130000
DTSTAMP:20260615T125014
CREATED:20210129T165333Z
LAST-MODIFIED:20210129T165333Z
UID:13439-1618318800-1618318800@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday\, April 13th\, 2021 at 1:00 PM.  We are pleased to invite all students\, postdocs\, faculty\, and staff.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-5/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210412T160000
DTEND;TZID=America/Los_Angeles:20210412T160000
DTSTAMP:20260615T125014
CREATED:20210323T203220Z
LAST-MODIFIED:20210323T203220Z
UID:13450-1618243200-1618243200@www.chemistry.ucla.edu
SUMMARY:Chem 228: Prof. Chanmin Su
DESCRIPTION:“Scanning probe microscopy for physical and chemical property characterizations at the nanoscale”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-prof-chanmin-su/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210407T160000
DTEND;TZID=America/Los_Angeles:20210407T160000
DTSTAMP:20260615T125014
CREATED:20210323T215118Z
LAST-MODIFIED:20210323T215118Z
UID:13459-1617811200-1617811200@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Charles W. Machan
DESCRIPTION:“Earth-Abundant Molecular Catalyst System for the Reduction of Dioxygen and Carbon Dioxide” \n Abstract: The steady increase in anthropogenic carbon dioxide (CO2) emissions and corresponding atmospheric concentrations continues to generate interest in using CO2 as a liquid fuel and commodity chemical precursor. The conversion of CO2 has the dual benefit of addressing its associated negative environmental effects and the diminishing supply of petrochemical feedstocks. At the heart of efficient reductive transformations are proton-coupled electron transfer (PCET) reactions\, where electrons and protons move in a concerted way to mitigate kinetic and thermodynamic penalties. Mechanistic understanding of these reactions can inform the design of optimized catalyst structures with improved activity and selectivity for specific products. Another cathodic reaction\, the electrocatalytic reduction of dioxygen (O2)\, has relevance to the development of more efficient fuel cells and can be similarly optimized through fundamental knowledge of the underlying PCET reactions. Molecular systems are well-positioned to provide a better understanding of these reactions because of the relative fidelity with which they can be characterized\, as well as the possibility for systematic testing of structure-function relationships through iterative molecular design. In addition to developing new Fe-\, Mn-\, and Cr-based molecular electrocatalysts for these reactions\, we are exploring the use of redox mediators and flow-based electrochemical reactors to understand how these reactions can be scaled relative to comparable heterogeneous systems.
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-charles-w-machan/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210405T160000
DTEND;TZID=America/Los_Angeles:20210405T160000
DTSTAMP:20260615T125014
CREATED:20210323T203536Z
LAST-MODIFIED:20210323T203536Z
UID:13451-1617638400-1617638400@www.chemistry.ucla.edu
SUMMARY:OCDS Seminar: Prof. Karin Chumbimuni-Torres
DESCRIPTION:“Electrochemical biosensors for viruses and bacteria: new approaches and challenges”
URL:https://www.chemistry.ucla.edu/seminars/ocds-seminar-prof-karin-chumbimuni-torres/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210402T153000
DTEND;TZID=America/Los_Angeles:20210402T153000
DTSTAMP:20260615T125014
CREATED:20210325T204556Z
LAST-MODIFIED:20210325T204556Z
UID:13467-1617377400-1617377400@www.chemistry.ucla.edu
SUMMARY:Chem 268: Prof. Hernan Garcia
DESCRIPTION:“Dissecting Transcriptional Dynamics in Development One Burst at a Time”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-prof-hernan-garcia/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210331T160000
DTEND;TZID=America/Los_Angeles:20210331T160000
DTSTAMP:20260615T125014
CREATED:20210323T213721Z
LAST-MODIFIED:20210323T213721Z
UID:13458-1617206400-1617206400@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Wenliang Huang
DESCRIPTION:“f-Block metal-arene interactions: from inverse sandwiches to redox chemistry” \nAbstract: Recent years have witnessed the breakthrough of identifying unusual oxidation states of f-block elements in molecular compounds such as divalent rare earth metals and actinides\, as well as tetravalent terbium and praseodymium. By taking advantage of the symmetry and energy match between the f/d orbitals of low-valent f-block ions and π* orbitals of arenes\, we synthesized a series of metal arene complexes featuring an inverse-sandwich structure. We found that δ bonds are responsible for the unusual stability of the tetranionic arene anions in such compounds. Moreover\, f-block ions show a significant covalent character\, and the extent of covalent interaction increases according to the order: rare earth metals < thorium < uranium. Inspired by these metal-arene δ bonding interactions\, as well as the traditional π-donor character of arene ligands\, we designed a tripodal-type tris(amide) ligand system featuring an arene anchor. We anticipated that the amphiphilic nature of the arene backbone may support both low and high valent f-block metal centers. This strategy allowed us to stabilize multiple oxidation states of f-block metals with a single ligand and opened up new avenues in the redox chemistry of these ions.
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-wenliang-huang/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210319T130000
DTEND;TZID=America/Los_Angeles:20210319T130000
DTSTAMP:20260615T125014
CREATED:20210308T180314Z
LAST-MODIFIED:20210308T180314Z
UID:13449-1616158800-1616158800@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:“Invention of Catalysts for Synthesis of New Plastics” \n Abstract: This presentation will begin with a brief discussion of the properties of polyethylene and the synthesis of various forms of polyethylene via early metal catalysts and via free radical processes. Following this short discussion\, I will discuss our thought processes in developing late metal olefin polymerization catalysts and focus particularly on the chemistry of Ni(II) and Pd(II) diimine-derived catalysts. The talk will finish with a discussion of issues surrounding copolymerization of ethylene and polar vinyl monomers and a mechanistic dissection of the copolymerization of ethylene with vinyl trialkoxysilanes using both Pd(II) and Ni(II) diimine catalysts.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-6/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210318T120000
DTEND;TZID=America/Los_Angeles:20210318T120000
DTSTAMP:20260615T125014
CREATED:20210225T175009Z
LAST-MODIFIED:20210225T175009Z
UID:13445-1616068800-1616068800@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Arundhati Deshmukh
DESCRIPTION:“Tuning the Excitonic Properties of 2-Dimensional Molecular Aggregates across the Visible and Shortwave Infrared” \n Molecular aggregates are non-covalent self-assemblies of chromophores wherein transition dipole moments of individual molecules couple coherently over long distances\, forming delocalized excitons. This imparts exciting photophysical properties such as extreme blue or red shifts (seen in H- or J-aggregates respectively)\, narrow linewidths and high molar absorptivities. We modulate the transition dipole couplings within an aggregate via molecular packing\, topology\, and disorder in order to tune and explore new photophysical behaviors. In this talk\, I will discuss the unusual situation that arises from 2D transition dipole coupling in sheet-like aggregates. In addition to traditional H- and J-aggregation\, we find a new case of ‘I-aggregation’ which shows intermediate characteristics of H- and J-aggregates. I will also describe how we use thermodynamics of self-assembly to control the aggregate packing and thereby\, tune excitonic properties. Using a three-component equilibrium model\, I will lay down general principles for selectively stabilizing H- or J-aggregates\, allowing us to construct a library of 2D J-aggregates with absorptions spanning the visible and shortwave infrared (SWIR) regions. Finally\, I will show how subtle differences in chromophore structures within this library modulate the aggregate packing and eventually lead to distinct excitonic band pictures\, that can be experimentally probed using temperature dependent spectroscopy. Overall\, this work establishes molecular aggregation as a tunable avenue for accessing unusual photophysical properties and thus\, opens up organic chromophores to new functionalities including SWIR imaging\, plexitonics\, and telecommunications.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-arundhati-deshmukh/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210312T153000
DTEND;TZID=America/Los_Angeles:20210312T153000
DTSTAMP:20260615T125014
CREATED:20210104T172741Z
LAST-MODIFIED:20210104T172741Z
UID:13405-1615563000-1615563000@www.chemistry.ucla.edu
SUMMARY:CANCELLED - Chem 268: Prof. Hernan Garcia
DESCRIPTION:“Dissecting Transcriptional Dynamics in Development One Burst at a Time”
URL:https://www.chemistry.ucla.edu/seminars/cancelled-chem-268-prof-hernan-garcia/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210311T130000
DTEND;TZID=America/Los_Angeles:20210311T130000
DTSTAMP:20260615T125014
CREATED:20210304T164257Z
LAST-MODIFIED:20210304T164257Z
UID:13447-1615467600-1615467600@www.chemistry.ucla.edu
SUMMARY:CIC Careers in Green Chemistry Seminar Series
DESCRIPTION:The Center for Integrated Catalysis is hosting a new seminar series called the “Careers in Green Chemistry.” With these webinars\, we aim to bring speakers from a wide variety of careers\, linked through green chemistry\, to come talk about their current job as well as the career path that led them to that position. We are pleased to invite all students\, postdocs\, and faculty.
URL:https://www.chemistry.ucla.edu/seminars/cic-careers-green-chemistry-seminar-series/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210311T120000
DTEND;TZID=America/Los_Angeles:20210311T120000
DTSTAMP:20260615T125014
CREATED:20210120T173102Z
LAST-MODIFIED:20210120T173102Z
UID:13430-1615464000-1615464000@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: David Reilley
DESCRIPTION:Chemical Change in Protein Molecular Dynamics: Developing Computational Tools for Metal Binding and pH Sensitivity \n Molecular dynamics (MD) is a powerful tool to study atomic scale changes in proteins underpinning biological pathways. However\, simulations traditionally sample a fixed chemical state and struggle to achieve quantitatively accurate energies\, making comparisons of different chemical ensembles challenging. Hybrid quantum mechanical-classical approaches (QM/MM) can provide accurate energies for small regions of interest\, such as the active site\, but cannot readily capture all chemical transformations relevant to protein function. This talk will focus on developments and applications of hybrid methods to study the metal binding preferences and pH sensitivity of proteins. We will first discuss how we used QM/DMD combined with a competitive metal affinity method\, a semi-empirical thermodynamic cycle\, to obtain relative binding affinities for a wide range of metals to human serum transferrin (hTF)\, an iron transport protein. Our results clarified a mechanism for promiscuous metal binding in hTF and the role the protein may play in transport of non-physiological and potentially cytotoxic metals. We will then discuss the development of a titration feature for constant pH simulations with DMD (titr-DMD). Our method features stochastic protonation and deprotonation of amino acids while treating solvent implicitly\, which makes it computationally efficient compared to other techniques. We successfully benchmarked titr-DMD on experimentally verified pH-dependent conformational changes. Our work demonstrates the utility of molecular dynamics\, and QM/DMD in particular\, to study chemical changes in proteins with good accuracy and speed.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-david-reilley/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210310T160000
DTEND;TZID=America/Los_Angeles:20210310T160000
DTSTAMP:20260615T125014
CREATED:20210120T172051Z
LAST-MODIFIED:20210120T172051Z
UID:13425-1615392000-1615392000@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Long Luo
DESCRIPTION:Electrifying Inorganic and Organic Synthesis \nAbstract: Electrochemical synthesis is a powerful tool for formulating functional materials and moleculesbecause it offers an additional level of control over the synthesis relative to its chemical counterpart by fine-tuning mass transfer\, potential\, or current. Electrochemical synthesis also allows the convenient analysis of chemical reaction thermodynamics and kinetics using the current signal generated during the electrochemical synthesis. In this talk\, two recent advancements in electrochemical synthesis will be presented: (1) Electrochemical gelation of nanoparticles and (2) Alternating current electrolysis for organic synthesis. 
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-long-luo/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210310T120000
DTEND;TZID=America/Los_Angeles:20210310T120000
DTSTAMP:20260615T125014
CREATED:20210304T164531Z
LAST-MODIFIED:20210304T164531Z
UID:13448-1615377600-1615377600@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Wenfei Li
DESCRIPTION:Developing Highly Efficient Electronic Structure Theory Methods for Large Scale Simulations \n Electronic structure simulations are now becoming an indispensable tool in chemistry research. The overall goal is to develop methods that give accurate results without sacrificing efficiency. In our group\, we incorporate various computational techniques to drastically reduce the cost of simulations. This allows us to run large scale simulations that were not previously possible. Our major innovation is stochastic quantum chemistry\, where we replaced the summation over thousands of deterministic orbitals to an average over much smaller number of stochastic orbitals\, and sometimes only a few suffices. This leads to significant increase in efficiency. In this seminar\, I will talk about my two projects under the stochastic quantum chemistry framework. The first project involved developing an embedding stochastic framework\, where a sub-system of interest is treated using deterministic orbitals\, while the rest of the system is treated using stochastic orbitals. This way\, we can selectively reduce the stochastic errors associated with that sub-system. The second project involved finding an optimal DFT starting point for our stochasticGW code. Apart from that\, I will also introduce our orthogonal projector augmented wave package. Compared with the norm-conserving pseudopotential approach\, the PAW method will allow a lower kinetic energy cutoff\, hence greatly enhances the efficiency of electronic structure theory simulations.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-wenfei-li/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210308T160000
DTEND;TZID=America/Los_Angeles:20210308T160000
DTSTAMP:20260615T125014
CREATED:20210120T182725Z
LAST-MODIFIED:20210120T182725Z
UID:13435-1615219200-1615219200@www.chemistry.ucla.edu
SUMMARY:Chem 228: Peter Dahlberg\, Ph.D.
DESCRIPTION:“Combining cryogenic single-molecule fluorescence measurements and CryoEM: New methods with applications from biology to physical chemistry”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-peter-dahlberg-phd/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210305T133000
DTEND;TZID=America/Los_Angeles:20210305T133000
DTSTAMP:20260615T125014
CREATED:20210104T172651Z
LAST-MODIFIED:20210104T172651Z
UID:13403-1614951000-1614951000@www.chemistry.ucla.edu
SUMMARY:Chem 268: Prof. Benjamin Falcon
DESCRIPTION:“Amyloid conformers in neurodegenerative disease”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-prof-benjamin-falcon/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210304T160000
DTEND;TZID=America/Los_Angeles:20210304T160000
DTSTAMP:20260615T125014
CREATED:20210120T235559Z
LAST-MODIFIED:20210120T235559Z
UID:13438-1614873600-1614873600@www.chemistry.ucla.edu
SUMMARY:Break-it-to-Make-it Strategies for Chemical Synthesis Inspired by Complex Natural Products”
DESCRIPTION:Abstract: Natural products continue to inspire and serve as the basis of new medicines. They also provide intricate problems that expose limitations in the strategies and methods employed in chemical synthesis. Several strategies and methods that have been developed in our laboratory and applied to the syntheses of architecturally complex diterpenoid alkaloids\, indole alkaloids\, and several Lycopodium alkaloids\, will be discussed. In addition\, new ways to employ C–C bond cleavage in synthesis will be presented (i.e.\, break-it-to-make-it strategies).
URL:https://www.chemistry.ucla.edu/seminars/break-it-make-it-strategies-chemical-synthesis-inspired-complex-natural-products/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210304T120000
DTEND;TZID=America/Los_Angeles:20210304T120000
DTSTAMP:20260615T125014
CREATED:20210120T172927Z
LAST-MODIFIED:20210120T172927Z
UID:13429-1614859200-1614859200@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Sophia King
DESCRIPTION:Controlling the Architecture of Nanoporous Materials to Regulate their Thermal Conductivity and Optical Transparency for Energy Efficient Windows \n Transparent\, low thermal conductivity coatings can be applied to windows to increase the energy efficiency of buildings. Amorphous material such as silica make good thermal insulators due to their local atomic disorder that impedes heat conduction. Moreover\, pores can be added to the material to further reduce heat conduction by decreasing the material density while adding interfaces can additionally scatter heat carriers. This concept is often used in highly porous silica aerogels\, which are valued for their ultra-low thermal conductivities. However\, these aerogels significantly scatter light\, and therefore cannot be used for applications that require high optical transparency. This talk focuses on our ongoing efforts to design silica-based coating that are insulating as well as optically transparent. First\, I will describe our efforts using mesoporous thin films to expand on our fundamental understanding of heat transport in nanoporous\, silica-based materials. Next\, I will discuss how the knowledge gained from these thin film studies influenced our design of novel precursors and a scalable synthetic method to produce monoliths that can be used in thermal insulation applications. Finally\, I will describe our efforts to use small angle X-ray scattering (SAXS) to follow structural changes in porous materials with the goal of understanding how surface chemistry and drying dynamics influence pore structure to produce materials with desired thermal conductivity and optical quality.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-sophia-king/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210303T160000
DTEND;TZID=America/Los_Angeles:20210303T160000
DTSTAMP:20260615T125014
CREATED:20210120T171640Z
LAST-MODIFIED:20210120T171640Z
UID:13424-1614787200-1614787200@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Sheng Xu
DESCRIPTION:Controlled epitaxial growth and fabrication of hybrid halide perovskites \nAbstract: Organic–inorganic hybrid halide perovskites have demonstrated tremendous potential for next-generation electronic and optoelectronic devices due to their remarkable carrier dynamics. Current studies are mostly focused on polycrystals\, since controlled growth of high-quality single crystals is challenging. In this presentation\, I will discuss strategies that enabled the first chemical epitaxial growth of single-crystal hybrid halide perovskites. Using advanced microfabrication\, homo-/hetero-epitaxy\, and a low-temperature solution method\, single crystals can be grown with controlled locations\, morphologies\, orientations\, and strain levels. By a lifting off approach\, single-crystal thin films can be transferred from the epitaxial substrate to a general flexible substrate. This approach opens up broad opportunities for hybrid halide perovskite materials based high-performance electronic and optoelectronic devices.
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-sheng-xu/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210303T123000
DTEND;TZID=America/Los_Angeles:20210303T123000
DTSTAMP:20260615T125014
CREATED:20210301T205743Z
LAST-MODIFIED:20210301T205743Z
UID:13446-1614774600-1614774600@www.chemistry.ucla.edu
SUMMARY:Dissertation Seminar: Cliff Boldridge
DESCRIPTION:“Specificity in Protein-Protein Interactions: High-Throughput Characterization of Rationally Designed and Naturally Evolved Coiled-Coil Networks”
URL:https://www.chemistry.ucla.edu/seminars/dissertation-seminar-cliff-boldridge/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210302T120000
DTEND;TZID=America/Los_Angeles:20210302T120000
DTSTAMP:20260615T125014
CREATED:20210225T000105Z
LAST-MODIFIED:20210225T000105Z
UID:13444-1614686400-1614686400@www.chemistry.ucla.edu
SUMMARY:Proximity-enabled Reactivity for Biological Studies
DESCRIPTION:Abstract: To genetically introduce new chemical reactivity into live systems\, we engineered the genetic code to encode a new class of unnatural amino acids (Uaas)\, the latent bioreactive Uaas. These Uaas\, after being incorporated into proteins\, specifically react with target natural amino acid residues via proximity-enabled reactivity\, enabling the selective formation of new covalent linkages within and between proteins both in vitro and in live systems. These diverse reactivities\, inaccessible to natural proteins\, open doors to novel protein engineering\, biological research\, and therapeutic applications. I will present specific examples of using the proximity-enabled reactivity to probe ligand-receptor binding\, to identify elusive protein-protein interactions\, and to develop covalent protein drugs for cancer immunotherapy.
URL:https://www.chemistry.ucla.edu/seminars/proximity-enabled-reactivity-biological-studies/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210301T160000
DTEND;TZID=America/Los_Angeles:20210301T160000
DTSTAMP:20260615T125014
CREATED:20210120T182417Z
LAST-MODIFIED:20210120T182417Z
UID:13434-1614614400-1614614400@www.chemistry.ucla.edu
SUMMARY:Chem 228: Ben Zhong Tang
DESCRIPTION:“Aggregology: Science beyond Molecules”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-ben-zhong-tang/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210226T153000
DTEND;TZID=America/Los_Angeles:20210226T153000
DTSTAMP:20260615T125014
CREATED:20210104T172543Z
LAST-MODIFIED:20210104T172543Z
UID:13402-1614353400-1614353400@www.chemistry.ucla.edu
SUMMARY:Chem 268: Prof. Martin Kampmann
DESCRIPTION:“Elucidating cellular pathways controlling protein aggregation\, spread and toxicity in neurodegenerative disease”
URL:https://www.chemistry.ucla.edu/seminars/chem-268-prof-martin-kampmann/
CATEGORIES:Biochemistry,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210225T160000
DTEND;TZID=America/Los_Angeles:20210225T160000
DTSTAMP:20260615T125014
CREATED:20210120T201235Z
LAST-MODIFIED:20210120T201235Z
UID:13437-1614268800-1614268800@www.chemistry.ucla.edu
SUMMARY:New Strategies for the Efficient Preparation of Bioactive Compounds
DESCRIPTION:Abstract: Novel technologies\, preparative methods and synthetic strategies often represent a critical part of the investigation of new design ideas for bioactive compounds. Traditionally\, natural products were considered to be the most challenging targets\, but frequently medicinal chemistry structure-activity relationship (SAR) studies are also limited in practice by synthetic tractability. This presentation will select two to three topics from currently ongoing projects in our group that have benefited from key contributions from technological\, methodological\, and strategic innovations. \nFor example\, we have recently reported the synthesis of iminothienopyridinediones through photooxygenation reactions. Our lead structure in this series was found to be a potent inhibitor of the oncogenic\, dual-specific phosphatase PTP4A3 (in vitro IC50 ~35 nM)\, as well as its family members PTP4A1 and PTP4A2. The SAR analysis as well as the scale-up of the iminothienopyridinedione chemotype were greatly facilitated by in-flow techniques\, first using fluoroelastomer tubing and a compact fluorescent lamp (CFL)\, and then a 3-D printed polypropylene cartridge system under LED light irradiation. \nAnother case study to be presented focuses on strategic innovations in the total synthesis and the investigation of the CNS/GPCR effects of Ergot Alkaloids. In particular\, the influence of scaffold rearrangement and stereochemistry on the serotonin (5-HT) receptor modulation of Ergot Alkaloid analogs will be highlighted\, a biological property that is significant for their potential for future development as anti-depression and anti-anxiety pharmaceuticals.
URL:https://www.chemistry.ucla.edu/seminars/new-strategies-efficient-preparation-bioactive-compounds/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210225T120000
DTEND;TZID=America/Los_Angeles:20210225T120000
DTSTAMP:20260615T125014
CREATED:20210120T172737Z
LAST-MODIFIED:20210120T172737Z
UID:13428-1614254400-1614254400@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Dane Stanfield
DESCRIPTION:A Tale of Two Doping Mechanisms: Controlling the Formation of Charge Transfer Complexes in Chemically Doped Semiconducting Polymers \nDoping of organic semiconductors has emerged as a viable route for the inexpensive fabrication of numerous electronic devices such as light emitting diodes\, thin film transistors\, and thermoelectric generators. The p-type doping of polymer based semiconductors like P3HT is achieved through the introduction of chemically strong oxidizing agents like F4TCNQ that usually undergo integer charge transfer\, removing an electron from the extended  conjugation network\, leaving behind a charged hole in its place that is free to conduct at the bulk level. In contrast\, p-type doping of small molecule based semiconductors typically results in formation of charge transfer complexes\, where close spatial contact and orbital overlap between the host and guest species cause fractional charge transfer to occur. It has to date remained unclear why polymeric based semiconductors show a preference for doping via integer charge transfer while their small molecule counterparts usually undergo formation of fractional charge transfer complexes. In this talk\, we will discuss recent advances in our understanding of the mechanisms that drive these two different types of charge transfer interactions in conjugated polymers. We show that it is possible to exert control over the type and abundance of each type of charge transfer interaction through the simple selection of processing solvent solubility parameters. We are also able to assign two structurally unique packing arrangements that correspond to integer or fractional charge transfer and compare the relative thermal stabilities of these two polymorphs. Finally\, we show that the CN groups found on the dopant molecule\, F4TCNQ\, can serve as a probe of the local electric field strength and thus the environment of the charge carriers as detected via the vibrational stark effect. Overall\, this improved understanding of polymer-dopant interactions allows us to provide new guidelines for enhancing the doping efficiency and limiting the occurrence of fractional charge transfer states in doped semiconducting polymers.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-dane-stanfield/
CATEGORIES:Other,Seminars
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END:VCALENDAR