BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20240310T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20241103T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240418T160000
DTEND;TZID=America/Los_Angeles:20240418T170000
DTSTAMP:20260614T234246
CREATED:20240311T052349Z
LAST-MODIFIED:20240311T052349Z
UID:32764-1713456000-1713459600@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Tianning Diao
DESCRIPTION:Leveraging One- and Two-Electron Mechanisms in Nickel-Catalyzed Cross-Coupling \nAbstract: While palladium-catalyzed cross-coupling reactions have revolutionized the construction of multi-aryl scaffolds in pharmaceutical synthesis\, the reactivity of nickel in mediating radical pathways has expanded the scope of cross-coupling to include various alkyl motifs. Through our mechanistic investigations and an understanding of ligand effects\, we established that strong -donor and -acceptor ligands\, with redox activity\, facilitate nickel catalysts to initiate radical formation\, capture radicals\, and direct bond formation from open-shell intermediates. Given the orthogonal reactivity of radicals with polar functional groups in biomolecules\, these radical pathways have introduced innovative methods for synthesizing non-canonical peptides and carbohydrates\, important for drug discovery. In contrast\, two-electron pathways are crucial for nickel-catalyzed bi-aryl coupling. Building on this insight\, we developed a novel ligand that enhances the reactivity of nickel-catalyzed Suzuki-Miyaura couplings\, paving the way for the application of nickel catalysts in pharmaceutical process synthesis. \nDiao Flyer
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-tianning-diao/
LOCATION:Collaboratory Yoo Seminar & Conference Hall YH4222 
CATEGORIES:Organic Colloquium
END:VEVENT
END:VCALENDAR