BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20240310T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20241103T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240311T160000
DTEND;TZID=America/Los_Angeles:20240311T170000
DTSTAMP:20260614T195215
CREATED:20231219T222948Z
LAST-MODIFIED:20240311T210203Z
UID:31879-1710172800-1710176400@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry Seminar 228: Douglas Rees
DESCRIPTION:Prof. Doug Rees Flyer \nTalk Title: Nitrogenase: Beyond the Resting State \nAbstract: The enzyme nitrogenase has the remarkable ability to catalyze the reduction of dinitrogen to ammonia to under physiological conditions. The mechanistic questions related to how nitrogenase overcomes the kinetic stability of the NN triple bond to fix dinitrogen under ambient conditions have intrigued chemists for the past century. We have applied a structure-based approach to examine how nitrogenase uses iron-sulfur metalloclusters and ATP-dependent electron transfer to reduce dinitrogen and other substrates. A puzzling feature of the nitrogenase mechanism has been how to reconcile the relative stability of the FeMo-cofactor with the reactivity towards dinitrogen. Our studies have established that binding of ligands to nitrogenase under turnover conditions can be accompanied by the reversible displacement and rearrangements of sulfurs in the catalytic FeMo-cofactor; these rearrangements may provide clues how the active site is activated during the catalytic cycle. The complementary strengths of X-ray and electron scattering are being used to illuminate the structural foundations of this process.
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-seminar-228-douglas-rees/
LOCATION:Collaboratory Yoo Seminar & Conference Hall YH4222 
CATEGORIES:Physical,Physical Chemistry Seminar
END:VEVENT
END:VCALENDAR