BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231116T160000
DTEND;TZID=America/Los_Angeles:20231116T170000
DTSTAMP:20260614T120128
CREATED:20230815T234122Z
LAST-MODIFIED:20230815T235036Z
UID:30807-1700150400-1700154000@www.chemistry.ucla.edu
SUMMARY:Distinguished Lecture Series: Prof. David Christianson
DESCRIPTION:Title: Directing Biosynthesis with Modular Architecture in Terpene Cyclases \nAbstract: Terpene cyclases catalyze the most complex chemical reactions in biology\, in that more than half of the carbon atoms in an isoprenoid substrate undergo changes in bonding or hybridization during a multi-step cyclization cascade that proceeds through multiple carbocation intermediates. Although the substrate pool for these enzymes is limited to only a handful of linear isoprenoids\, more than 100\,000 terpenoid natural products have been identified to date. Crystal structures of terpene cyclases reveal common\, modular protein folds that direct unique catalytic strategies underlying this exquisite chemodiversity. Most recently\, structural studies of bifunctional assembly-line terpene synthases using cryo-EM and other biophysical techniques show how the first two steps of terpene biosynthesis are combined in nanoscale oligomeric assemblies. Cluster channeling within the oligomer ensures efficient carbon management in wild-type and mutant enzymes.
URL:https://www.chemistry.ucla.edu/events/distinguished-lecture-series-prof-david-christianson/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Distinguished Lecture Series
END:VEVENT
END:VCALENDAR