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DTSTART;TZID=America/Los_Angeles:20230124T130000
DTEND;TZID=America/Los_Angeles:20230124T143000
DTSTAMP:20260613T214312
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UID:26961-1674565200-1674570600@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series: Parisa Mehrkhodavandi
DESCRIPTION:Title: Cationic indium in catalysis: Generation of functionalized copolymers from commodity monomers \nAbstract: Cationic indium complexes are rare in the field of catalysis. We have developed families of cationic indium complexes supported by tridentate and tetradentate aminophenolate ligands which show reactivity towards cyclic esters\, cyclic ethers\, and copolymerizations with CO 2. We show that\, depending on ligand design\, these complexes are excellent catalysts for the coupling of functionalized epoxides and cyclic esters to form orthoesters\, for the controlled ring opening polymerization of cyclic ethers\, and for the copolymerization of cyclic ethers and esters. Structure-function relationships and mechanistic considerations in each of these systems will be explored.
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-for-integrated-catalysis-webinar-series-parisa-mehrkhodavandi/
CATEGORIES:Other,Seminars
LOCATION:
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DTSTART;TZID=America/Los_Angeles:20230124T160000
DTEND;TZID=America/Los_Angeles:20230124T170000
DTSTAMP:20260613T214312
CREATED:20230107T033525Z
LAST-MODIFIED:20230107T033525Z
UID:27094-1674576000-1674579600@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Dr. Jose Roque
DESCRIPTION:Modern drug discovery has benefited from advancements in chemical reaction development. For example\, C–H functionalization reactions has transformed how synthetic chemists approach the retrosynthetic analysis of bioactive compounds. Despite recent advances\, the development of site-selective reactions remains a grand challenge in metal-catalyzed C–H functionalization. Typical retrosynthetic analysis results in simplified fragments by the removal of functional groups on the periphery of molecules. As a result\, forward syntheses and diversification of molecules have focused on peripheral modifications. Inspired by the concept of scaffold hopping\, the first part of the presentation will detail an approach to access novel chemical space by focusing on making structural edits to the core framework of molecules. The second part of the presentation will center on addressing site-selectivity and the need for more active first-row transition metal catalysts\, as the low activity and limited scope of known first-row transition metal catalysts severely limit their utility. Cobalt precatalysts supported by pyridine dicarbene pincers have been developed to selectively functionalize electronically distinct C–H bonds without relying on directing groups contrasting traditional approaches. For example\, the meta-selective C(sp2)–H borylation of fluoroarenes\, a significant challenge due to the weak coordinating ability and the similar size of fluorine and hydrogen\, has been demonstrated. Mechanistic studies on fluoroarene borylation established a kinetic preference for C–H bond activation at the meta position\, while cobalt-aryl complexes resulting from ortho C–H activation are thermodynamically preferred. As a result of these mechanistic insights\, the selectivity of a C–H borylation can be switched with a single catalyst by simply modifying the reaction conditions.
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-dr-jose-roque/
LOCATION:Young Hall 2033
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