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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230117T110000
DTEND;TZID=America/Los_Angeles:20230117T120000
DTSTAMP:20260613T214249
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UID:26926-1673953200-1673956800@www.chemistry.ucla.edu
SUMMARY:Special Biochem Seminar -Jinfan Wang
DESCRIPTION:Title: How does protein synthesis start in eukaryotes?
URL:https://www.chemistry.ucla.edu/events/special-biochem-seminar-jinfan-wang/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230117T160000
DTEND;TZID=America/Los_Angeles:20230117T170000
DTSTAMP:20260613T214249
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LAST-MODIFIED:20230107T032733Z
UID:27088-1673971200-1673974800@www.chemistry.ucla.edu
SUMMARY:Special Houk-Jung Organic Colloquium 247: Dr. Alistair Sterling
DESCRIPTION:Strain is a foundational concept in organic chemistry. Its presence can transform an inert molecule into one with exciting properties\, or steer a reaction toward a single product with exquisite control. Understanding—and importantly\, predicting—the delicate balance between strain and reactivity will enable the full potential of strain to be harnessed for drug discovery\, materials chemistry\, bioconjugation and beyond. In this talk\, efforts to uncover the fundamental principles that govern strain release chemistry will be discussed\, using the highly-strained hydrocarbon [1.1.1]propellane to develop the concept of bond delocalization\,1 before demonstrating how this idea can be generalized to predict the behaviour of all small-ring carbocycles.2 The implications of this interplay between strain\, bonding and reactivity will be explored through reaction development built upon halogen bonding and photoredox catalysis\,3\,4 offering guidelines to develop reactions that capitalize on strain release reactivity.5  \n[1] Sterling\, A. J.\, Dürr\, A. B.\, Smith\, R. C.\, Anderson\, E. A.\, Duarte\, F.\, Chem. Sci. 2020\, 11\, 4895–4903. \n[2] Sterling\, A. J.\, Smith\, R. C.\, Anderson\, E. A.\, Duarte\, F.\, ChemRxiv 2021 (https://doi.org/10.26434/chemrxiv-2021-n0xm9). \n[3] Livesly\, S.\, Sterling\, A. J.\, Robertson\, C. C.\, Goundry\, W.\, Morris\, J. A.\, Duarte\, F.\, Aïssa\, C.\, Angew. Chem. Int. Ed. 2022\, 61\, e202111291. \n[4] Wong\, M. L. J.\, Sterling\, A. J.\, Mousseau\, J. J.\, Duarte\, F.\, Anderson\, E. A.\, Nat. Commun. 2021\, 12\, 1644. \n[5] Frank\, N.\, Nugent\, J.\, Shire\, B. R.\, Pickford\, H. D.\, Rabe\, P.\, Sterling\, A. J.\, Zarganes-Tzitzikas\, T.\, Grimes\, T.\, Thompson\, A. L.\, Smith\, R. C.\, Schofield\, C. J.\, Brennan\, P. E.\, Duarte\, F.\, Anderson\, E. A.\, Nature 2022\, 611\, 721–726.
URL:https://www.chemistry.ucla.edu/events/special-houk-jung-organic-colloquium-247-dr-alistair-sterling/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
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