BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T110000
DTEND;TZID=America/Los_Angeles:20230109T120000
DTSTAMP:20260614T015621
CREATED:20230105T210547Z
LAST-MODIFIED:20230105T210751Z
UID:27032-1673262000-1673265600@www.chemistry.ucla.edu
SUMMARY:Special Biochemistry Seminar - Michael Lawson
DESCRIPTION:Michael Lawson Seminar \nTitle: Defining the Pathways of Eukaryotic Translational Quality Control \nAbstract: My research examines how protein synthesis concludes on normal and defective mRNAs. Understanding how these processes are choregraphed is crucial for human health; for example\, 11% of all heritable human diseases are caused by premature stop codons. As a postdoctoral fellow\, I defined the molecular events that liberate polypeptides from ribosomes as translation concludes on normal mRNAs. Using an in vitro reconstituted yeast translation system and single-molecule assays\, I tracked the interplay of eukaryotic release factors (eRF1 and eRF3) with ribosomes halted at stop codons. I discovered that eRF1 and eRF3 act together to quickly recognize stop codons and elicit termination via a tightly regulated process that resembles how ribosomes select proper tRNAs in translation elongation\, which explains how translation termination is fast yet also specific for stop codons. Since the release factors are well conserved throughout eukaryotes\, these mechanisms are likely a fundamental feature of eukaryotic protein synthesis. My work also revealed that diverse effectors inhibit translation termination to promote stop codon readthrough\, suggesting a new route to treat diseases caused by premature stop codons which includes cystic fibrosis and hereditary cancers. In the future\, I will use single-molecule and structural approaches to watch translation unfold on defective mRNAs to understand the molecular events used to evaluate mRNAs and prevent the repeated synthesis of toxic proteins.
URL:https://www.chemistry.ucla.edu/events/special-biochemistry-seminar-michael-lawson/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Biochemistry,Special Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T150000
DTEND;TZID=America/Los_Angeles:20230109T155000
DTSTAMP:20260614T015621
CREATED:20220921T214630Z
LAST-MODIFIED:20220922T213346Z
UID:24058-1673276400-1673279400@www.chemistry.ucla.edu
SUMMARY:Organic Student Seminar 248: Aaron Chavarria
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/seminars/organic-student-seminar-2023-01-09/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230109T160000
DTEND;TZID=America/Los_Angeles:20230109T170000
DTSTAMP:20260614T015621
CREATED:20221222T223942Z
LAST-MODIFIED:20230106T003643Z
UID:26977-1673280000-1673283600@www.chemistry.ucla.edu
SUMMARY:Physical Chemistry 228: Dr. Youn Jue (Eunice) Bae
DESCRIPTION:Dr. Bae Flyer
URL:https://www.chemistry.ucla.edu/events/physical-chemistry-228-dr-youn-jue-eunice-bae/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Physical Chemistry Seminar
END:VEVENT
END:VCALENDAR