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DTSTART;TZID=America/Los_Angeles:20221201T120000
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DTSTAMP:20260614T032152
CREATED:20221107T181840Z
LAST-MODIFIED:20221107T181840Z
UID:26041-1669896000-1669899600@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Mengzhen Chen
DESCRIPTION:
URL:https://www.chemistry.ucla.edu/events/chem-218-student-exit-seminar-mengzhen-chen/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Chem 218 Student Exit Seminar
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221201T160000
DTEND;TZID=America/Los_Angeles:20221201T170000
DTSTAMP:20260614T032152
CREATED:20220902T214825Z
LAST-MODIFIED:20221019T232951Z
UID:23358-1669910400-1669914000@www.chemistry.ucla.edu
SUMMARY:Houk-Jung Organic Colloquium 247: Sidney Wilkerson-Hill
DESCRIPTION:Seminar Sponsored by Organization for Cultural Diversity in Science \nProf Wilkerson Hill Flyer \nTitle: Orphaned Cyclopropanes \nAbstract: Cyclopropanes are strained carbocycles that have fascinated chemists for decades with many established methods for their construction. Unfortunately\, many methods struggle to build cyclopropanes containing only alkyl functionality\, which limits access to antiviral medicines (e.g.\, nirmatrelvir)\, pyrethroid insecticides and sesquiterpenoid natural products. These cyclopropanes have been “orphaned” or left behind by state-of-the-art cycloaddition methods and are typically characterized as arising from the transfer of a unstabilized carbene unit. The goals of the Hill group are to develop new methods to obtain orphaned cyclopropanes and to use these strategies to address the coming “insectocalypse”. To this end\, we have developed three cyclopropanation methods that break with traditional paradigms and enable the rational design and facile access to orphaned cyclopropanes. Our most recent approach leverages the high reactivity of lithiosulfones to transfer dialkyl carbene groups to styrenes.
URL:https://www.chemistry.ucla.edu/events/houk-jung-organic-colloquium-247-sidney-wilkerson-hill/
LOCATION:Mani L. Bhaumik Centennial Collaboratory\, 607 Charles E. Young Dr.\, East\, Los Angeles\, CA\, 90095\, United States
CATEGORIES:Organic Colloquium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20221201T160000
DTEND;TZID=America/Los_Angeles:20221201T173000
DTSTAMP:20260614T032152
CREATED:20221117T170552Z
LAST-MODIFIED:20221122T015649Z
UID:26218-1669910400-1669915800@www.chemistry.ucla.edu
SUMMARY:Inaugural Dickerson Lecture Biochemistry Seminar Series: Robert M. Stroud
DESCRIPTION:Flyer: Dickerson Lecture Flyer – Robert M. Stroud \nTitle: “Caught in the Act! – Building the Wall!” \nAbstract: From the atomic structure of the first protein\, Myoglobin in which Richard Dickerson played the key role(1)\, proteins were necessarily purified from large animals. Now complex machines can be ‘tagged’ and purified endogenously from cells growing under normal conditions(2)\, revealing their endogenous partnerships\, natural substrates\, and reactions as if trapped ‘in action’. The mycolic acid layer of the Mycobacterium tuberculosis cell wall is essential for viability and virulence\, and the enzymes responsible for its synthesis are therefore targets for antimycobacterial drug development. Polyketide synthase 13 (Pks13) performs the key essential final condensation of mycolic acids. Structures determined by cryogenic electron microscopy of dimeric multi-enzyme Pks13 purified from mycobacteria\, are captured with native endogenous long-chain fatty acid substrates. Structures define the ketosynthase (KS)\, linker domains\, and acyltransferase (AT) domains at 1.8 Å resolution\, and show two alternate locations of the N-terminal acyl carrier protein that delivers substrate from a fatty acid synthase to the KS domain. Other domains\, visible only at low resolution\, are flexible relative to the KS-AT core. These structures\, together with cross linking and integrative modeling suggest intermediate states on the pathway to mycolic acid synthesis(3).
URL:https://www.chemistry.ucla.edu/events/inaugural-dickerson-lecture-biochemistry-seminar-series/
LOCATION:Boyer 159\, 611 Charles E Young Dr E\, Los Angeles\, CA 90095\, Los Angeles\, CA\, 90095\, United States
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