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DTSTART;TZID=America/Los_Angeles:20220301T110000
DTEND;TZID=America/Los_Angeles:20220301T110000
DTSTAMP:20260614T170021
CREATED:20220223T182222Z
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UID:13609-1646132400-1646132400@www.chemistry.ucla.edu
SUMMARY:Chem 228: Prof. Denis Usvyat
DESCRIPTION:“High-accuracy Theoretical Treatment of Defects in Periodic Systems”
URL:https://www.chemistry.ucla.edu/seminars/chem-228-prof-denis-usvyat/
CATEGORIES:Physical Chemistry Seminar,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220301T130000
DTEND;TZID=America/Los_Angeles:20220301T130000
DTSTAMP:20260614T170021
CREATED:20220223T185306Z
LAST-MODIFIED:20220223T185306Z
UID:13610-1646139600-1646139600@www.chemistry.ucla.edu
SUMMARY:NSF Center for Integrated Catalysis Webinar Series
DESCRIPTION:“2D Particle Surfactants and Pickering Emulsions for Reagent Compartmentalization”
URL:https://www.chemistry.ucla.edu/seminars/nsf-center-integrated-catalysis-webinar-series-12/
CATEGORIES:Other,Seminars
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220301T160000
DTEND;TZID=America/Los_Angeles:20220301T160000
DTSTAMP:20260614T170021
CREATED:20220225T013934Z
LAST-MODIFIED:20220225T013934Z
UID:13611-1646150400-1646150400@www.chemistry.ucla.edu
SUMMARY:Special Organic Colloquium - Prof. Stuart Conway
DESCRIPTION:“The development and targeting of epigenetic drugs for therapeutic benefit” \nAbstract: The talk will comprise two interconnected parts describing the development and targeting of epigenetic drugs for the treatment of disease.  \nThe development of bromodomain ligands for the treatment of disease: bromodomains\, protein modules that ‘read’ of lysine acetylation state\, have emerged as important therapeutic targets for indications including oncology. I will describe our work on the design and synthesis of inhibitors for the BET and CREBBP/EP300 bromodomains\, their biological effects\, and their role as leads for cancer drug discovery. While the function of some human bromodomain-containing proteins (BCPs) has been heavily investigated\, little is known about the role of these proteins in other species. I will describe work to identify 22 BCPs in Schistosoma mansoni (schistosomiasis/bilharzia). We have annotated one of these proteins as SmBRD3\, in analogy to human BRD3\, a member of the BET bromodomain family. I will discuss the design\, synthesis\, and validation of high affinity ligands for SmBRD3 and the use of these ligands in phenotypic studies on S. mansoni.  \nTargeting and imaging tumour hypoxia: Tumor hypoxia (low oxygen) is associated with therapy resistance and poor patient prognosis. Hypoxia-activated prodrugs\, which target oxygen-deficient cells\, represent a promising treatment strategy. We have demonstrated the pre-clinical efficacy of NI-Pano\, a novel hypoxia-activated pro-drug of the clinically used lysine deacetylase inhibitor\, panobinostat. NI-Pano is stable in normoxic (21% oxygen) conditions and undergoes NADPH-CYP-mediated enzymatic bioreduction to release panobinostat in hypoxia (<0.1% oxygen). NI-Pano exhibited growth delay effects as a single agent in mouse tumor xenografts. Pharmacokinetic analysis confirmed the presence of panobinostat in hypoxic mouse xenografts\, but not in circulating plasma or kidneys. Our preclinical results provide a strong mechanistic rationale for the clinical development of NI-Pano for selective targeting of hypoxic tumors. Work to develop complementary imaging agents for hypoxia will also be discussed.
URL:https://www.chemistry.ucla.edu/seminars/special-organic-colloquium-prof-stuart-conway/
CATEGORIES:Organic Colloquium,Seminars
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