BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220209T103000
DTEND;TZID=America/Los_Angeles:20220209T103000
DTSTAMP:20260614T181013
CREATED:20220204T010500Z
LAST-MODIFIED:20220204T010500Z
UID:13603-1644402600-1644402600@www.chemistry.ucla.edu
SUMMARY:Strategic Bond Construction and Cleavage Enabled by Photocatalytic Radical Transformations
DESCRIPTION:Abstract: Radical chemistry is an important class of reactions in modern organic synthesis\, due to the high reactivity and versatile bond formation and cleavage events that can happen with radical intermediates. One of the current challenges in radical chemistry is to generate these reactive open-shell intermediates from accessible starting materials under mild conditions. We have developed several powerful strategies to homolytically cleave strong X–H bonds and generate the corresponding X• radical via proton-coupled electron transfer (PCET). In this talk\, I will present a photocatalytic intermolecular anti-Markovnikov hydroamination reaction of sulfonamides\, and a remote C–H alkylation reaction of amides\, enabled by the amidyl radicals generated via PCET. Moreover\, we also developed a photocatalytic condition to conduct various carbocation reactions via mesolytic cleavage of alkoxyamine compounds. Lastly\, to understand the remarkable chemoselectivity and improve the quantum efficiency of a set of photocatalytic hydroamination reactions\, we performed detailed mechanistic studies\, using advanced spectroscopic and electroanalytical tools to unveil the origin of the chemoselectivity of this reaction\, and also improved the reaction quantum yields. Based on these studies\, gram-scale synthesis of several dialkylamines were performed in a flow reactor.
URL:https://www.chemistry.ucla.edu/seminars/strategic-bond-construction-and-cleavage-enabled-photocatalytic-radical-transformations/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220209T160000
DTEND;TZID=America/Los_Angeles:20220209T160000
DTSTAMP:20260614T181013
CREATED:20211215T172113Z
LAST-MODIFIED:20211215T172113Z
UID:13564-1644422400-1644422400@www.chemistry.ucla.edu
SUMMARY:Chem 278: Prof. Robert Macfarlane
DESCRIPTION:“Macroscopic Materials from Nanoparticle Assembly”
URL:https://www.chemistry.ucla.edu/seminars/chem-278-prof-robert-macfarlane/
CATEGORIES:Inorganic Chemistry,Seminars
END:VEVENT
END:VCALENDAR