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DTSTART:20220313T100000
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DTSTART:20221106T090000
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220113T120000
DTEND;TZID=America/Los_Angeles:20220113T120000
DTSTAMP:20260615T005211
CREATED:20220105T195255Z
LAST-MODIFIED:20220105T195255Z
UID:13587-1642075200-1642075200@www.chemistry.ucla.edu
SUMMARY:Special Physical Chemistry Seminar - Elsa Sanchez Garcia
DESCRIPTION:“CL-FEP: An Accurate End-State Free Energy Perturbation Approach”
URL:https://www.chemistry.ucla.edu/seminars/special-physical-chemistry-seminar-elsa-sanchez-garcia/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220113T160000
DTEND;TZID=America/Los_Angeles:20220113T160000
DTSTAMP:20260615T005211
CREATED:20210830T220452Z
LAST-MODIFIED:20210830T220452Z
UID:12326-1642089600-1642089600@www.chemistry.ucla.edu
SUMMARY:Postponed: Chapman Lectureship
DESCRIPTION:The Chapman Lecture has been postponed until futher notice. 
URL:https://www.chemistry.ucla.edu/events/postponed-chapman-lectureship/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220113T160000
DTEND;TZID=America/Los_Angeles:20220113T160000
DTSTAMP:20260615T005211
CREATED:20220112T232706Z
LAST-MODIFIED:20220112T232706Z
UID:13590-1642089600-1642089600@www.chemistry.ucla.edu
SUMMARY:Stereoselective Gold Catalysis: From Metal-Ligand Cooperation to SN2 Glycosylation
DESCRIPTION:Abstract: Metal-ligand cooperation is a versatile strategy for achieving efficient and/or stereoselective catalysis. Since 2014\, we have developed a range of enabling remotely basic group-functionalized biaryl-2-ylphospine ligands (see Scheme A) for cooperative gold catalysis. With chiral elements built into these ligands\, asymmetric transformations are developed in mechanistically rational manners. DFT calculations confirm the critical participation of the ligand remote basic group in catalysis. Several recent developments will be discussed. This type of bifunctional ligands also enables cooperative catalysis by other metals including Cu and Ag. \nA different yet related approach to achieving stereoselective gold catalysis is developed specifically to address the long-standing challenge in carbohydrate synthesis\, i.e.\, the lack of stereoselective synthesis of glycosidic bonds applicable to every sugar type. In this approach\, as shown in Scheme B\, a basic group is installed onto the anomeric leaving group of the carbohydrate donor and serves to direct the backend attack by a carbohydrate acceptor upon the leaving group activation by gold. The SN2 nature of the glycosylation and the general tolerance of many sugar types make this approach appealing. The progress made in this area will be discussed.
URL:https://www.chemistry.ucla.edu/seminars/stereoselective-gold-catalysis-metal-ligand-cooperation-sn2-glycosylation/
CATEGORIES:Organic Colloquium,Seminars
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