BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210422T120000
DTEND;TZID=America/Los_Angeles:20210422T120000
DTSTAMP:20260618T143521
CREATED:20210419T163230Z
LAST-MODIFIED:20210419T163230Z
UID:13491-1619092800-1619092800@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Fang-Chu Lin
DESCRIPTION:“Superparamagnetic Core/Shell Mesoporous Silica Nanoparticle for Magnetic Heating-Induced Anticancer Drug Delivery” \n ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPION) generate heat in the presence of an alternating magnetic field (AMF) and are used in clinics to treat cancers. Mesoporous silica nanoparticles (SPION@MSN) embedded with SPION possess the advantageous features of both the SPION core and the shell\, i.e.\, localized magnetic heating and a high payload of various cargo molecules such as anticancer drugs\, respectively. This talk focuses on the development of SPION@MSNs as a heat-activated drug delivery platform in which the precise drug release can be directly controlled by using AMF. To expand our knowledge base in this application\, we first study the local heating mechanism of a SPION in suspension and in MSN. We carried out this investigation by using fluorescence depolarization based on detecting the mobility-dependent polarization anisotropy of two luminescence emission bands corresponded to the luminescent SPION core and the shell of the SPION@MSN. Utilizing the magnetic heating\, we then designed a magnetically activated and enzyme-responsive SPION@MSN vehicle with extra-large pores to deliver and release anticancer peptides on-demand. We demonstrate that a SPION core can act as a nano-heater to stimulate a cascade drug release and high tumor-targeting/inhibiting efficiency can be achieved. Altogether\, these works show the full potential of AMF-controlled core/shell nanoparticle vehicles for a more selected and precise dosage control.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-fang-chu-lin/
CATEGORIES:Other,Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210422T160000
DTEND;TZID=America/Los_Angeles:20210422T160000
DTSTAMP:20260618T143521
CREATED:20210329T184047Z
LAST-MODIFIED:20210329T184047Z
UID:13477-1619107200-1619107200@www.chemistry.ucla.edu
SUMMARY:Understanding the chemistry of volcanic RNA to treat cancer & COVID-19
DESCRIPTION:Abstract: N4-acetylcytidine is an ancient RNA modification catalyzed by an enzyme essential for human life. However\, its distribution\, dynamics\, and function remain mysterious. In this seminar I will introduce my group’s work developing chemical tools to investigate RNA acetylation\, why this led us to study an organism that thrives in solfatara (volcanic craters)\, and how we are using these fundamental studies to enable new therapeutic approaches.
URL:https://www.chemistry.ucla.edu/seminars/understanding-chemistry-volcanic-rna-treat-cancer-covid-19/
CATEGORIES:Organic Colloquium,Seminars
END:VEVENT
END:VCALENDAR