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DTSTART:20210314T100000
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DTSTART;TZID=America/Los_Angeles:20210218T120000
DTEND;TZID=America/Los_Angeles:20210218T120000
DTSTAMP:20260618T193016
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LAST-MODIFIED:20210120T172619Z
UID:13427-1613649600-1613649600@www.chemistry.ucla.edu
SUMMARY:Chem 218 Student Exit Seminar: Mary Grumbles
DESCRIPTION:“Strategies for Modulating Stabilities of Soft and Hard Hybrid Materials with Boron Clusters” \n Carbon chemistry is ubiquitous across the development of modern materials. In comparison\, use of boron building blocks is underdeveloped\, owing to the historic instability of simple boranes. Polyhedral boranes\, however\, fundamentally differ from their borane precursors and exhibit exceptional chemical stability as a result of three-dimensional\, delocalized aromaticity. My talk will highlight the utility of polyhedral boranes to generate hybrid materials with unique stability profiles. Specifically\, I will discuss the use of polyhedral boranes as matrices for ion shuttling\, highlighting the tolerance of these species to repeated electrochemical cycling in the presence of both moisture and water. After\, I will discuss efforts to amend unprotected peptides with polyhedral boranes. My talk will highlight the distinct physical and chemical properties of the resulting bioconjugates\, emphasizing the ability of these species to slow proteolytic degradation. Finally\, I will describe ongoing efforts within the Spokoyny lab to develop and investigate these hybrid borane materials.
URL:https://www.chemistry.ucla.edu/seminars/chem-218-student-exit-seminar-mary-grumbles/
CATEGORIES:Other,Seminars
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DTSTART;TZID=America/Los_Angeles:20210218T160000
DTEND;TZID=America/Los_Angeles:20210218T160000
DTSTAMP:20260618T193016
CREATED:20210120T193820Z
LAST-MODIFIED:20210120T193820Z
UID:13436-1613664000-1613664000@www.chemistry.ucla.edu
SUMMARY:Recent progress in the discovery of non-hormonal male contraceptive agents
DESCRIPTION:Abstract: There is a global need for novel contraceptive methods because worldwide about 40% of pregnancies are still unintended\, about 42 million pregnancies are terminated by abortion\, and 658 women per day die of pregnancy-related problems in the US (CDC 2020). While many contraceptive options exist for women\, fewer are available for men. Testosterone-based contraceptives for men have been investigated for 60 years but challenges remain for commercialization. For these reasons and to provide couples with additional safe and reversible options for contraception\, the development of non-hormonal contraceptives for both men and women is highly desirable to assist with family planning and reduce unintended pregnancies. Advances in the understanding of reproductive biology have provided many testis-specific targets that are under investigation for the discovery and development of a male contraceptive agent that involve reduction of sperm counts\, effect spermiation\, prevent sperm maturation\, or block sperm motility. However\, developing agents that are highly effective\, very safe and completely reversible is a very significant challenge. Recent progress on the discovery of inhibitors for the testis-specific bromodomain (BRDT) will be discussed. Based on the discovery that some kinase inhibitors are dual kinase/bromodomain inhibitors (ACS Chem. Biol. 2013\, 8\, 2360 and ACS Chem. Biol. 2014\, 16\, 1160) efforts towards the discovery of selective BRDT monovalent and bivalent BRDT inhibitors will be presented.
URL:https://www.chemistry.ucla.edu/seminars/recent-progress-discovery-non-hormonal-male-contraceptive-agents/
CATEGORIES:Organic Colloquium,Seminars
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