BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//UCLA - ECPv5.14.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:UCLA
X-ORIGINAL-URL:https://www.chemistry.ucla.edu
X-WR-CALDESC:Events for UCLA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20210120T160000
DTEND;TZID=America/Los_Angeles:20210120T160000
DTSTAMP:20260618T194225
CREATED:20210106T191623Z
LAST-MODIFIED:20210106T191623Z
UID:13410-1611158400-1611158400@www.chemistry.ucla.edu
SUMMARY:Special Bio-Inorganic Chemistry Seminar
DESCRIPTION:“Chemical and Biological Design Approaches to Controlling Protons\, Electrons\, and Substrates for Sustainable Catalysis”  \nAbstract: The reductive transformation of small molecules into value-added products represents an attractive way to store sustainable energy in chemical bonds. Achieving this efficiently and selectively requires the careful management of not only the substrate and intermediates\, but also the proton and electron equivalents. Both the synthesis of small molecule catalysts and the de novodesign of metalloproteins offer the means to control these multi-component reactions. A commonly observed strategy in biological systems to lower the barrier to reductive protonation of small molecules is concerted proton-electron transfer (CPET). However\, the application of such a strategy to chemical catalysis has been lacking due to the paucity of approaches to generate CPET donors sufficiently reactive to functionalize molecules of interest ranging from N2 to ketones. Here\, I will discuss our discovery that under the protic conditions relevant to nitrogen fixation catalysis that metallocenes can serve as CPET reagents and our subsequent design of functionalized cobaltocenes suitable to electrocatalytic CPET applications. I will then finish by touching on the computational\, de novo design of non-heme iron proteins for O2-activation. These enzymes utilize a co-substrate to selectively generate a reactive metal-oxo intermediate that is useful for both C–H and olefin functionalization reactions. Nonetheless\, such enzymes have been thus far little explored in the context of protein engineering.
URL:https://www.chemistry.ucla.edu/seminars/special-bio-inorganic-chemistry-seminar-3/
CATEGORIES:Other,Seminars
END:VEVENT
END:VCALENDAR