Martinson, Harold G.
Graduate Program in Biochemistry and Molecular Biology, JCCC Gene Regulation Program Area
Young Hall 5040A
Young Hall 5033
Dr. Martinson received his Ph.D. in Molecular Biology from the University of California, Berkeley. He was a Postdoctoral Scholar at the University of California, San Francisco.
Coupling of RNA Processing With Transcription
Broadly speaking we are interested in how the genes of organisms transmit their information to the cellular biosynthetic machinery. We are especially interested in how this is accomplished in the most complex of organisms—eukaryotes in general, but especially in mammals. RNA polymerase II is the enzyme charged with initiating the transfer of information from the DNA in the nucleus to the cell cytoplasm via RNA. Amazingly, RNA polymerase not only carries out the intricate task of precisely transcribing the DNA, but it also oversees the elaborate network of events involved in processing the RNA that it makes. Our focus is on the functional interactions of the transcriptional machinery with the machineries responsible for cleavage & polyadenylation and for splicing.
RNA Transcription Model