Koehler, Carla M.


WebsiteHome URL
Division
Biochemistry
Title
Faculty
Professor
Specialties
Biochemistry
Systems Biology and Biological Regulation
Metabolism
Aging and Development
Chemical Biology
Member
UCLA-Jonsson Comprehensive Cancer Center,Molecular Biology Institute,Brain Research Institute,UCLA ACCESS Program

Contact Information

Email
Office
Young Hall 4041A
(310) 794-4834
Lab
Young Hall 4043
(310) 825-8427

Short Biography

M.S. and Ph.D., Iowa State University Post-doctorate, Biozentrum, University of Basel

Research Interest

Mitochondrial Biogenesis - Protein Translocation into Mitochondria

 

 

 

 

Our research encompasses two major areas: Understanding the mechanism of protein import into mitochondria and determining the process by which defects in mitochondrial protein translocation lead to disease.

A basic question in cell biology is the mechanism by which a protein reaches its correct location within the cell. Of all the organelles in a mammalian cell, the mitochondrion is the most complex because two membranes must be crossed. In addition to the metabolic role, the mitochondria is a key player in many cellular processes including apoptosis, metal ion homeostasis and aging. My specific interests lie in mitochondrial biogenesis, particularly the mechanism by which proteins are imported into the mitochondrial inner membrane.

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Publications

2014

  • Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1. Miyata N, Steffen J, Johnson ME, Fargue S, Danpure CJ, Koehler CM. Proc Natl Acad Sci U S A. 2014 Sep 18. pii: 201408401. [Epub ahead of print] PMID: 25237136
  • TMEM14C is required for erythroid mitochondrial heme metabolism. Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C, Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger TM, DiMauro S, Orkin SH, Cantor AB, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL, Paw BH. J Clin Invest. 2014 Oct 1;124(10):4294-304. doi: 10.1172/JCI76979. Epub 2014 Aug 26. PMID: 25157825
  • Mitochondria-targeted RNA import. Wang G, Shimada E, Nili M, Koehler CM, and Teitell MA. Methods Mol. Biol. 2014 In Press.

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2004

EDITED BOOKS

The Koehler Research Lab